Periodic paralysis

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Diagram of muscle channelopathies showing hypokalemic periodic paralysis on a spectrum of channelopathy diseases.
Periodic paralyses are types of muscle channelopathies.
Image: K June-Bum, 2014[1] CC-BY-NC-3.0

Periodic paralysis is a temporary paralysis of part of the body, with reoccurring episodes that last from minutes to hours.[2] There are different types of periodic paralysis, and it can be genetic (inherited) or acquired. Periodic paralysis conditions are types of muscle channelopathies, also known as myopathies.[1][3]

Types of periodic paralysis[edit | edit source]

Different types of periodic paralysis include:

Caused by low potassium.[3][4]
Caused by high potassium.[3][4]
Considered a variant of hyperkaleimic periodic paralysis, patients grow weaker when potassium levels rise.[4]
Linked to thyroid hormone levels.[4]
Caused by an inherited defect in a potassium channel, which affects both the heart and skeletal muscles. Patients with Andersen-Tawil Syndrome can experience heart rhythm disturbances even when their blood potassium is normal.[3][4]
Paramyotonia Congenita [4]

Periodic paralysis in ME/CFS[edit | edit source]

Some people with ME/CFS develop acquired periodic paralysis; the episodes of limb paralysis occur because of the ion transportation symptoms found in some people with ME/CFS.[5][6] Paralysis is not recognized in the International Consensus Primer, but the ion transport and channelopathy impairments that cause it are mentioned in the pathophysiology section, and the response to exercise section.[6]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 Kim, June-Bum (January 2014). "Channelopathies". Korean Journal of Pediatrics. 57 (1): 1–18. doi:10.3345/kjp.2014.57.1.1. ISSN 1738-1061. PMC 3935107. PMID 24578711.
  2. Dissanayake, HA; Padmaperuma, PACD (July 18, 2018). "Periodic paralysis: what clinician needs to know?". Endocrinology & Metabolism International Journal. 6 (4). doi:10.15406/emij.2018.06.0018. ISSN 2473-0815.
  3. 3.0 3.1 3.2 3.3 Muscular Dystrophy Association. "Myopathies: Facts" (PDF). Retrieved November 29, 2018.
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Periodic Paralysis International. "What is Periodic Paralysis?". Retrieved January 18, 2019.
  5. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7–115, doi:10.1300/J092v11n01_02
  6. 6.0 6.1 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6