Periodic paralysis is a temporary paralysis of part of the body, with reoccurring episodes that last from minutes to hours. There are different types of periodic paralysis, and it can be genetic (inherited) or acquired. Periodic paralysis conditions are types of muscle channelopathies, also known as myopathies.
Types of periodic paralysis[edit | edit source]
Different types of periodic paralysis include:
- Hypokalemic periodic paralysis (HyperKPP)
- Hyperkalemic periodic paralysis (HypoKPP)
- Normokalemic periodic paralysis (NormoKPP)
- Considered a variant of hyperkaleimic periodic paralysis, patients grow weaker when potassium levels rise.
- Paramyotonia Congenita 
Periodic paralysis in ME/CFS[edit | edit source]
Some people with ME/CFS develop acquired periodic paralysis; the episodes of limb paralysis occur because of the ion transportation symptoms found in some people with ME/CFS. Paralysis is not recognized in the International Consensus Primer, but the ion transport and channelopathy impairments that cause it are mentioned in the pathophysiology section, and the response to exercise section.
See also[edit | edit source]
- Hypokalemic periodic paralysis
- Channelopathy hypothesis
- Ion transportation
Learn more[edit | edit source]
- What is periodic paralysis? - Periodic Paralysis International
- Periodic paralysis - what clinician needs to know?
- Myopathies: Facts - genetic and acquired periodic paralysis conditions
References[edit | edit source]
- Kim, June-Bum (Jan 2014). "Channelopathies". Korean Journal of Pediatrics. 57 (1): 1–18. doi:10.3345/kjp.2014.57.1.1. ISSN 1738-1061. PMC . PMID 24578711.
- Dissanayake, HA; Padmaperuma, PACD (Jul 18, 2018). "Periodic paralysis: what clinician needs to know?". Endocrinology & Metabolism International Journal. 6 (4). doi:10.15406/emij.2018.06.0018. ISSN 2473-0815.
- Muscular Dystrophy Association. "Myopathies: Facts" (PDF). Retrieved Nov 29, 2018.
- Periodic Paralysis International. "What is Periodic Paralysis?". www.hkpp.org. Retrieved Jan 18, 2019.
- Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, A C Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7-115, doi:10.1300/J092v11n01_02
- Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.