Preload failure

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Preload failure or PLF occurs when the maximal exercise-induced cardiac output (CO) is decreased without an accompanying increase in right heart or pulmonary vascular pressures.[citation needed]

In cardiac physiology, preload is the end diastolic volume that stretches the right or left ventricle of the heart to its greatest dimensions under variable physiologic demand.[citation needed] It is defined as the length of the heart muscle just before it starts to pump and is measured clinically by the volume of blood in the left ventricle, the main pumping chamber, when it is most relaxed.[citation needed]

Preload can be influenced by blood volume, heart rhythm, left ventricular relaxation, and alterations in afterload.[citation needed]

ME/CFS[edit | edit source]

Preload failure is associated with exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome, orthostatic hypotension, and postural orthostatic tachycardia.[1]

Treatments[edit | edit source]

David Systrom at Brigham Women's Hospital in Boston is currently conducting phase III trials of Mestinon in patients with preload failure.[2]Pyridostigmine (the generic name for Mestinon) has been investigated previously.[1]

Notable studies and publications[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

physiological Concerning living organisms, such as cells or the human body.  Physio logical (as in physio) is not to be confused with psych ological (emotional stress).

phase three Last phase of clinical trials before a drug can be approved for public use. Whereas Phase one assesses basic safety, and Phase two assesses basic efficacy, Phase three uses many trial participants to fully assess both safety and efficacy, and overall benefit/risk.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.