Cerebral hypoperfusion

Cerebral hypoperfusion is inadequate blood flow to the brain. Chronic cerebral hypoperfusion is linked to neurocognitive disorders.

Orthostatic cerebral hypoperfusion syndrome

Novak (2016) states that orthostatic cerebral hypoperfusion syndrome (OCHOs) is defined by:

1. abnormal orthostatic drop of cerebral blood flow velocity (CBFv) during the tilt test and
2. absence of orthostatic hypotension, arrhythmia, vascular abnormalities, or other causes of abnormal orthostatic CBFv

Prevalence

A study by Dutch scientists of 429 ME/CFS patients found that 90% of them had an abnormal cerebral blood flow reduction (i.e. cerebral hypoperfusion) during orthostatic stress testing.

Notable studies

• 1995, Brainstem perfusion is impaired in chronic fatigue syndrome (Abstract)
• 2018, The etiologic relation between disequilibrium and orthostatic intolerance in patients with myalgic encephalomyelitis (chronic fatigue syndrome)
• Visser, van Campen, Rowe et al have published extensively on low blood flow to the brain in ME/CFS patients

Possible causes

Orthostatic intolerance

See also

• Disequilibrium
• Ataxia
• Brain
• Orthostatic intolerance
• Low blood pressure

cerebral 1. of or relating to the brain or the intellect 2. of, relating to, affecting, or being the cerebrum.

1. of or relating to the brain or the intellect 2. of, relating to, affecting, or being the cerebrum.}

cerebral 1. of or relating to the brain or the intellect 2. of, relating to, affecting, or being the cerebrum.

(CBF) - the amount of blood that goes through the arterial tree in the brain in a given amount of time

cerebral blood flow (CBF) - the amount of blood that goes through the arterial tree in the brain in a given amount of time

See myalgic encephalomyelitis.

See chronic fatigue syndrome.

brainstem Region of the midbrain in adults, includes midbrain, pons, and medulla oblongata and develops.

orthostatic intolerance (OI) - The development of symptoms when standing upright, where symptoms are relieved upon reclining. Patients with orthostatic intolerance have trouble remaining upright for more than a few seconds or a few minutes, depending upon severity. In severe orthostatic intolerance, patients may not be able to sit upright in bed. Orthostatic intolerance is often a sign of dysautonomia. There are different types of orthostatic intolerance, including postural orthostatic tachycardia syndrome (POTS).