Treatment trials

This page lists the recent as well as the ongoing registered medical trials on treatments for the symptoms of myalgic encephalomyelitis (ME) and post-acute sequelae of SARS-CoV-2 infection (PASC) as well as their results - if available.

Abbreviations

The following abbreviations are used in the tables below:

Trial type (TT)

Abbreviation	Meaning
NRCT	Non-randomized controlled trial
OLT	Open-label trial
RCT	Randomized controlled trial

Condition of the trial subjects (CS)

Abbreviation	Meaning
LC	Long COVID
ME	Myalgic encephalomyelitis
PC	Post COVID

Trial phase (TP)

Abbreviation	Meaning
1-4	Trial phase 1-4
n/a	Trial phase not applicable

Treatment category (TC)

Abbreviation	Meaning
C	Complementary and alternative medicine
D	Drug (pharmacotherapy)
O	Other
P	Psychotherapy
R	Rehabilitation
S	Supplements

Completed trials

Study completion	TC	Treatment	Targeted symptoms	Link / study ID	Study results	TT	TP	CS
2022-01-19	O	Biosound	many	NCT05848401	-	OLT	n/a	LC
2022-01-20	O	Physical exercise & oxygen	cardiopulmonary	NCT04898205		OLT	n/a	LC
2022-01-21	O	Virtual SFCAMINA	many	NCT04593225	-	RCT	n/a	ME
2022-01-31	D	Ruconest	neurological	NCT04705831	-	RCT	4	PC
2022-01-31	D	S-1226	respiratory	NCT04949386	-	RCT	2	PC
2022-02-14	S	Formula C™	many	NCT04828668	inconclusive[1]	RCT	n/a	LC, PC
2022-02-22	D	Fluvoxamine (SSRI)	parosmia	NCT05216614	-	RCT	2	PC
2022-02-28	R	Computerized cognitive training	cognitive	NCT05571852		OLT	n/a	LC, PC
2022-03-07	D	Sodium pyruvate nasal spray	many	NCT04871815	headache-, coughing/sneezing-, hypoxemia-, dyspnea-[2]	OLT	2/3	LC, PC
2022-03-10	R	Inspiratory muscle training	pulmonary, strength	NCT04811859		RCT	n/a	PC
2022-03-15	S	Palmitoylethanolamide & Luteolin	cognitive	NCT05311852		RCT	n/a	LC
2022-03-30	R	Rehabilitation (online)	respiratory, neurological	NCT05074771		OLT	n/a	PC
2022-04-22	C	Homeopathy	many	NCT05104749		RCT	3	LC, PC
2022-05-01	R	Physical exercise (online)	pain, cardiopulmonary capacity, mood, quality of life	NCT04983394		RCT	n/a	PC
2022-06-08	D	Prospekta	asthenia	NCT05074888	negligible improvements[3]	RCT	3	PC
2022-06-29	D	AXA1125	muscles, fatigue	NCT05152849	fatigue-[4]	RCT	2	LC
2022-07-01	R	Nordic walking	fatigue, quality of life	NCT05453188		OLT	n/a	LC, PC
2022-07-18	D	LYT-100	respiratory	NCT04652518	-	RCT	2	PC
2022-07-30	C	Laser acupuncture	immunological, dyspnea	NCT05271500		RCT	n/a	PC
2022-07-31	O	TDCS	fatigue, cognition, depression, quality of life	NCT05252481		RCT	n/a	PC
2022-09-01	O	Self-management	many	NCT05268523		RCT	1/2	LC, PC
2022-10-10	S	Curcumin & Boswellia serrata & Vitamin C	many	NCT05150782		OLT	n/a	LC, PC
2022-10-13	O	Virtual self-management	many	NCT05107440		OLT	n/a	LC
2022-10-14	R	Cardiorespiratory telerehabilitation	many	NCT04996212		RCT	n/a	LC, PC
2022-11-18	S	Bioarginina C (supplement)	physical exhaustion, systemic inflammation, endothelial function	NCT04947488		OLT	n/a	PC
2022-11-20	R	High tone power therapy	fitness, fatigue	NCT05217771		RCT	n/a	PC
2022-11-30	R	Computerized cognitive training	fatigue, cognitive	NCT05582603		OLT	2	PC
2022-12-01	R	Circuit training	fitness	NCT05323331		RCT	n/a	PC
2022-12-04	D	Probiotic	many	NCT05080244	-	RCT	n/a	LC
2022-12-05	O	Vagus nerve stimulation	many	NCT05608629	mood+, fatigue-[5]	OLT	n/a	ME
2022-12-10	R	Diagrammatic breathing & resistance training	many	NCT05543551		OLT	n/a	PC
2022-12-20	R	Whole body vibration training	fitness, many	NCT05119634		RCT	n/a	PC
2022-12-20	D	Emoxypine & Meldonium	fatigue	NCT05939622	fatigue-[6]	RCT	4	PC
2022-12-30	O	Pulsed ectromagnetic field / pulmonary rehabilitation	pulmonary	NCT05379517		RCT	n/a	PC
2022-12-30	R	Physiotherapy (online)	fitness, quality of life	NCT04742946		OLT	n/a	LC
2022-12-31	D	Oxaloacetate	fatigue	NCT05273372	fatigue--[7]	RCT	n/a	ME
2022-12-31	R	Multidisciplinary rehabilitation (online)	many	NCT04961333		RCT	n/a	LC
2022-12-31	O	Stellate ganglion block	many	NCT05812209		OLT	n/a	LC
2023-01-04	O	Vagus nerve stimulation	fatigue	NCT05679505		RCT	n/a	PC
2023-01-06	D	Medical marijuana (CBD)	safety of CBD	NCT04997395	CBD is safe[8]	OLT	2	LC
2023-01-12	C	Homeopathy	cough, dyspnea, fatigue	NCT05715554		OLT	n/a	PC
2023-01-15	D	Loratidine	many	CTRI/ 2022/07/043679	-	RCT	4	LC
2023-01-23	D	Low dose naltrexone & NAD+	fatigue	NCT04604704	fatigue--[9]	OLT	2	PC
2023-01-31	R	Balneotherapy & aquatic exercise	many	NCT05765591		RCT	n/a	PC
2023-01-31	S	Quercetin	many	NCT05730660	fatigue-, sleep issues-[10]	RCT	n/a	ME
2023-01-31	S	ImmunoVita (supplement)	many	NCT04301609	no significant improvements[11]	RCT	n/a	ME
2023-01-31	R	Inspiratory muscle training	many	NCT05196529	-	OLT	n/a	PC, ME
2023-02-01	R	Robotic assisted hand rehabilitation	health, independence, range of motion	NCT06137716		OLT	n/a	PC, ME
2023-02-02	R	Diaphragmatic exercises / incentive spirometer	pulmonary	NCT05787275		RCT	n/a	PC
2023-02-22	D	Vortioxetine (SSRI)	cognitive	NCT05047952	cognitive=[12]	RCT	2	PC
2023-02-28	R	Pulmonary rehabilitation	pulmonary	NCT05496842		OLT	n/a	PC
2023-03-02	O	Portable oxygen concentrator	pulmonary	NCT05212831		OLT	n/a	LC
2023-03-23	R	Pulmonary rehabilitation	pulmonary	NCT05402007		RCT	n/a	LC, PC
2023-03-30	O	Vagus nerve stimulation	neuropsychological	NCT05389592		RCT	n/a	LC, PC
2023-03-31	O	Vagus nerve stimulation	pain	NCT05205577		OLT	n/a	LC
2023-03-31	D	RSLV-132	fatigue	NCT04944121	-	RCT	2	PC
2023-04-21	S	Omega 3	many	NCT05121766		RCT	1	PC
2023-05-18	D	Dextroamphetamine	fog	NCT05597722	-	RCT	4	PC
2023-05-23	O	Hydrogen water & biofeedback	many	NCT05397626		OLT	1	ME
2023-05-31	R	Cardiopulmonary exercise	many	NCT05035628		RCT	n/a	LC
2023-05-31	R	Physical exercise	many	NCT05204511		OLT	1	LC, PC
2023-05-31	R	Physical exercise	many	NCT06016192		OLT	n/a	PC
2023-06-01	C	Cupping therapy	immunological	NCT05901337		OLT	n/a	PC
2023-06-01	O	Hyperbaric oxygen therapy	pulmonary	NCT05977166		OLT	n/a	PC
2023-06-06	O	Plasma Exchange Therapy	many	NCT05445674		RCT	2	PC
2023-06-30	P	Mindfulness	many	NCT05566379		OLT	n/a	LC, PC
2023-06-30	P	Adhera (fatigue digital program)	many	NCT05483829 NCT05631171		OLT	n/a	LC
2023-07-06	R	Osteopathy & Physiotherapy	fatigue	NCT05012826		RCT	n/a	LC
2023-07-21	S	Lithium	fatigue, fog	NCT05618587		RCT	2	LC
2023-07-27	D	TNX-102 SL	pain	NCT05472090	-	RCT	2	PC
2023-07-30	R	Physiotherapy with neuromodulation	fatigue, sleep, quality of life	NCT05681455		RCT	n/a	PC
2023-07-31	D	Valacyclovir & Celecoxib (IMC-2)	fatigue, pain, POTS	Virios PR CTA	-	OLT	2	PC
2023-07-31	R	Resistance exercise	fitness, fatigue	NCT04900961		OLT	n/a	LC
2023-07-31	O	TDCS	many	NCT05780450		OLT	n/a	LC, PC
2023-08-01	R	Physical exercise (online)	fitness, sleep, anxiety, depression	NCT05381675		RCT	n/a	PC
2023-08-02	R	Cardiorespiratory rehabilitation (online)	fatigue, PEM, fitness	NCT05973136		OLT	n/a	PC
2023-08-10	C	Homeopathy	many	NCT06002230		OLT	n/a	LC
2023-08-11	D	PRS-220	pulmonary fibrosis	NCT05473533	-	RCT	1	n/a
2023-08-30	R	Sensory re-education training	disability, tactile sensation, handgrip strength	NCT05911113		RCT	n/a	PC
2023-08-30	R	Physical exercise	many	NCT05961462		RCT	n/a	LC
2023-08-31	R	Rehabilitation	fatigue	NCT05599906		OLT	n/a	LC
2023-08-31	D	Montelukast	respiratory	NCT04695704	-	RCT	3	LC
2023-09-01	S	Magnesium & Vitamin D	many	NCT05630339		RCT	n/a	PC
2023-09-12	D	Metoprolol (beta blocker)	tachycardias, POTS, hypertension	NCT05096884	-	OLT	1	PC
2023-09-12	D	Nirmatrelvir & ​Ritonavir (Paxlovid)	many	NCT05576662	-	RCT	2	PC
2023-09-22	R	Inspiratory & expiratory muscle training	many	NCT05597774		RCT	n/a	LC
2023-09-30	R	Physical exercise	physical & mental fitness	NCT05848518		RCT	n/a	LC, PC
2023-09-30	P	Active coping	pain	NCT05894629		RCT	n/a	PC
2023-09-30	D	Sulfureous water	cardiopulmonary, inflammation	NCT06294756		RCT	n/a	LC, PC
2023-10-01	O	GET & CBT	many	NCT05534997		OLT	n/a	PC
2023-10-01	D	Meplazumab	many	NCT05813587		RCT	3	PC
2023-10-04	D	Somatropin (growth hormone)	hormonal	NCT03554265		NRCT	3	PC
2023-10-18	D	Zofin	many	NCT05228899		RCT	2	LC
2023-10-30	D	Vericiguat	fatigue, PEM	NCT05697640		RCT	2	PC
2023-10-31	D	Medical marijuana	many	NCT05467904		RCT	n/a	LC
2023-11-01	D	IV Rintatolimod (Ampligen)	many	NCT05592418		RCT	2	PC, ME
2023-11-03	D	Probiotic: VSL#3®	many	NCT05874089		RCT	n/a	LC
2023-11-06	O	Triphala & HIIT	immune system, oxidative stress	NCT06208761	inconclusive[13]	RCT	2	LC
2023-11-14	R	Physical and respiratory rehabilitation	many	NCT05629884		OLT	n/a	LC, PC
2023-11-30	R	Telerehabilitation	many	NCT05817032		OLT	n/a	LC
2023-11-30	P	Cognitive training	cognitive, anxiety, depression	NCT05629897		OLT	n/a	LC, PC
2023-11-30	P	CBT & mindfulness	pain, anxiety, depression, insomnia	NCT05815693		OLT	n/a	LC, PC
2023-11-30	C	Acupuncture	fog, cognitive	NCT06144320		RCT	n/a	PC
2023-11-30	R	Physiotherapy	many	NCT05040893		OLT	n/a	LC
2023-12-01	D	Pimozide	tinitus	NCT05507372		OLT	n/a	PC
2023-12-11	D	Probiotic	many	NCT05975034		RCT	n/a	LC
2023-12-28	C	Tai chi	strength	NCT05501067		RCT	n/a	PC
2023-12-30	D	Fampridine	cognitive	NCT05274477		RCT	n/a	PC
2023-12-30	O	Stellate ganglion block & Bupivacaine	many	NCT05638620		OLT	1	LC, PC
2023-12-30	C	Yoga & self-management	many	NCT05697042		OLT	n/a	LC
2023-12-30	R	Rehabilitation	fatigue	NCT04836351		OLT	n/a	PC
2023-12-31	D	Longidaza	pulmonary	NCT06383819		RCT	3	LC
2023-12-31	O	Electrical stimulation	pain, fatigue, strength, endurance	NCT05200858		RCT	n/a	LC, PC
2023-12-31	D	Niagen	cognitive, depression, anxiety	NCT04809974		RCT	4	LC
2023-12-31	R	Physical exercise	cardiopulmonary	NCT05566483		OLT	n/a	LC
2023-12-31	C	Yoga & breathing & meditation	many	NCT05139979		RCT	n/a	LC, PC
2023-12-31	D	Pre-probiotic	fatigue	NCT06013072		RCT	n/a	PC
2023-12-31	D	Remdesivir	many	NCT04978259		OLT	4	LC
2023-12-31	D	CI-581a, CI-581b (glutamate modulator)	depression	NCT05690503		RCT	2	PC
2023-12-31	C	TaiChi-DTx (software)	cognitive, physical activity	NCT05419219		OLT	n/a	LC
2023-12-31	O	Hyperbaric oxygen therapy	pulmonary	NCT04905888		open RCT	2	LC
2023-12-31	R	Respiratory music therapy	pulmonary, many	NCT05231512		OLT	n/a	PC
2023-12-31	S	Creatine	many	NCT02374112		RCT	n/a	ME
2024-01-30	O	Omega 3 & Telerehabilitation	fatigue, fitness, depression, anxiety	NCT06063031		RCT	n/a	PC
2024-01-31	D	Beclomethasone	hyposmia	NCT05970731		RCT	2	LC, PC
2024-01-31	D	Bupivacaine	many	NCT05664711		OLT	1	ME
2024-01-31	R	Online respiratory physiotherapy	pulmonary	NCT05572346		OLT	n/a	LC
2024-01-31	R	Sub-symptom threshold Aerobic rehabilitation	many	NCT06172803		RCT	n/a	LC
2024-02-01	C	Chinese herbal medicine	fatigue	NCT05684952		RCT	2	LC
2024-02-01	O	Autologous stem-cell transplantation	many	NCT05669261		OLT	1	LC, PC
2024-02-01	P	Psychology	sleep, anxiety, depression	NCT05951803		RCT	n/a	LC
2024-02-01	D	Solriamfetol	fatigue, cognitive	NCT04622293		RCT	4	ME
2024-02-29	R	Home-based physical training	fitness, fatigue, cognitive	NCT05360563		OLT	n/a	PC
2024-02-29	R	Cognitive rehabilitation	many	NCT05731570		OLT	n/a	LC
2024-02-29	P	Self-management	many	NCT05658536		RCT	n/a	PC
2024-02-29	O	Vagus nerve stimulation	dysautonomia, fatigue, dyspnea, PEM, quality of life	NCT05630040		RCT	n/a	LC
2024-02-29	R	Physical exercise / incentive spirometry	pulmonary, fitness	NCT06191367		RCT	n/a	PC
2024-03-04	O	Hi-OxSR Sequential Rebreathing mask	cognitive	NCT06379620		OLT	1	LC
2024-03-27	R	Rehabilitation	many	NCT05855356		RCT	n/a	PC
2024-03-30	P	Psychology & breathing exercises	many	NCT05705154		RCT	1/2	LC
2024-03-31	R	Heart rate variability & biofeedback	many	NCT05228665	general symptoms- [14]	OLT	n/a	LC
2024-03-31	P	Cognitive behavioral therapy	fitness, fatigue, anxiety, depression	NCT05196451		RCT	n/a	PC
2024-03-31	D	Nirmatrelvir & Ritonavir	many	NCT05823896		RCT	2	LC
2024-03-31	R	Virtual home-based rehabilitation	many	NCT05298878		OLT	n/a	LC
2024-03-31	O	Nutrition & chronobiology & physical exercise	many	NCT05719493		OLT	n/a	ME
2024-03-31	O	Low carb diet	many	NCT05836402		RCT	n/a	LC
2024-03-31	O	Nutrition & physical rehabilitation	many	NCT05254301		OLT	n/a	PC
2024-03-31	O	Immunoadsorption	many	NCT05841498		RCT	n/a	PC
2024-03-31	D	BIO 300	respiratory	NCT04482595		RCT	2	PC
2024-04-20	R	Inspiratory muscle training	health parameters, fatigue	NCT06091358		OLT	n/a	LC
2024-04-30	S	Oxaloacetate	fatigue	NCT05840237		RCT	n/a	LC
2024-04-30	C	Bright light	fatigue, insomnia, anxiety, depression	NCT05677932		RCT	n/a	LC
2024-04-30	R	Home-based physical exercise	strength, fatigue, dyspnoea	NCT06073002		OLT	n/a	LC
2024-05-31	P	Psychoeducation	cognitive	NCT05167266		OLT	n/a	LC
2024-05-31	O	Hydroxy gas	many	NCT06159296		RCT	n/a	LC
2024-06-01	D	Low dose naltrexone (oral)	pain, inflammation, fatigue	NCT05430152		RCT	2	PC
2024-06-01	D	Sirolimus	pulmonary fibrosis	NCT04948203		OLT	3	COVID
2024-06-07	R	Pulmonary rehabilitation (online) / physical activity	fitness	NCT05299333		RCT	n/a	PC
2024-06-15	P	Amygdala & insula retraining	fatigue	NCT05851846		OLT	n/a	LC
2024-06-28	O	TDCS & Chlorella Pyreinodosa	biomarkers (B12, metilmalonic acid, homocysteine)	NCT06255600		RCT	n/a	LC
2024-06-28	O	TDCS	many	NCT06074848		OLT	2	PC
2024-06-30	O	TDCS	fatigue, cognition, depression, sleep, pain	NCT05753202		OLT	n/a	PC
2024-06-30	O	Faecal microbiota transplantation	sleep, anxiety, fatigue	NCT05556733		OLT	n/a	LC, PC
2024-06-30	S	Vitamin K2 & D3	biomarkers	NCT05356936		OLT	n/a	LC, PC
2024-06-30	D	Temelimab	neuropsychiatric	NCT05497089		RCT	2	PC
2024-06-30	O	Hyperbaric oxygen therapy	many	NCT04842448		RCT	2	PC
2024-06-30	R	Virtual Reality	many	NCT06374446		RCT	n/a	LC
2024-06-30	D	LAU-7b	many	NCT05999435		RCT	2/3	LC
2024-06-30	R	Breathing techniques & yoga	pulmonary, fatigue	NCT05732571		RCT	n/a	PC
2024-06-30	O	Self-management	many	NCT06208696		NRCT	n/a	LC
2024-07-01	D	Nirmatrelvir & ​Ritonavir (Paxlovid)	many	NCT05595369		RCT	2	COVID, LC
2024-07-30	R	Qigong	physical health	NCT05675995		OLT	n/a	LC, PC
2024-07-30	S	Lithium	many	NCT06108297		OLT	1	LC
2024-07-30	S	Resveratrol & Quercetin	asthma, breathing	NCT05601180		RCT	n/a	LC
2024-07-31	O	External encounter counterpulsation	fatigue	NCT05668039		RCT	n/a	LC
2024-07-31	O	Vagus nerve stimulation	many	NCT05445427		OLT	n/a	PC
2024-07-31	R	Incentive spirometry	many	NCT05813873		RCT	n/a	LC
2024-08-01	O	GWAS (Genome-wide association study)	many	DecodeME		GWAS	n/a	ME

Ongoing trials

Estimated study completion	TC	Treatment	Targeted symptoms	Link / study ID	TT	TP	CS
2024-08-31	O	Hyperbaric oxygen therapy	many	NCT06159309	OLT	n/a	PC
2024-08-31	C	Acupuncture & TCM	cognitive	NCT06042777	RCT	n/a	LC
2024-08-31	D	Cetirizine / Famotidine	many	NCT05946551	RCT	3	LC
2024-09-01	D	Ivabradin	POTS	NCT05481177	RCT	4	LC, PC
2024-09-01	R	Pulmonary rehabilitation	pulmonary	NCT05244044	RCT	n/a	LC
2024-09-01	R	Diaphragmatic breathing	many	NCT06330376	RCT	n/a	PC
2024-09-25	O	Ultrasound	fatigue	NCT06189066	OLT	n/a	PC
2024-09-30	P	Psychotherapeutic intervention	many	NCT05453201	OLT	n/a	LC, PC
2024-09-30	O	Electronic case management (software)	many	NCT05019963	RCT	n/a	LC
2024-09-30	R	Cognitive training	cognitive	NCT05338749	OLT	n/a	LC, PC
2024-10-08	R	Physical exercise (online)	fitness, cardiopulmonary, sleep	NCT05205460	RCT	n/a	PC
2024-10-31	R	Inspiratory muscle training	fitness, blood pressure, neurovascular ctrl.	NCT06091384	RCT	n/a	PC
2024-10-31	D	Nirmatrelvir & ​Ritonavir (Paxlovid)	many	NCT05668091	RCT	2	LC
2024-10-31	O	RegeneCyte	many	NCT05682560	RCT	2	LC
2024-10-31	R	Physical exercise	cardiopulmonary	NCT06065033	OLT	n/a	LC, PC
2024-10-31	R	Multi-disciplinary recovery program	many	NCT05167227	RCT	n/a	LC
2024-10-31	D	Valacyclovir & Celecoxib	fatigue	NCT06316843	RCT	2	LC, PC
2024-11-30	D	Efgartigimod	POTS	NCT05633407	RCT	2	PC
2024-11-30	O	Hydrogen water	fatigue, physical function, stress	NCT06227273	OLT	n/a	ME
2024-12-01	R	NeuroFlex (brain training software)	cognitive, fatigue, depression	NCT05705193	OLT	n/a	LC
2024-12-01	R	Cognitive rehabilitation	cognitive	NCT0567604	OLT	n/a	LC
2024-12-01	O	Sauna	many	NCT05931497	OLT	n/a	LC
2024-12-15	S	ImmuneRecov (proteins & supplements)	pulmonary	NCT06166030	OLT	3	PC
2024-12-30	R	Breathing exercises	blood oxygen level	NCT06165835	OLT	n/a	LC, PC
2024-12-31	C	Multimodal integrative naturopathic therapy	many	NCT04927403	OLT	n/a	PC
2024-12-31	O	Mindfulness with Muse S™ Headband	stress, anxiety	NCT05199233	OLT	n/a	PC
2024-12-31	S	Prednisolone & Vitamin B1, B6 and B12	many	NCT05638633	RCT	3	PC
2024-12-31	O	Photobiomodulation	oral complaints	NCT05760092	RCT	2	LC
2024-12-31	R	Inspiratory muscle training	dyspnea	NCT05024474	RCT	n/a	LC, PC
2024-12-31	R	Cognitive trainig & physical activity & mindfulness	many	NCT05846126	RCT	n/a	LC, PC
2024-12-31	D	Metformin	many	NCT06147050	RCT	3	PC
2024-12-31	D	Atorvastatin	neurocognitive	NCT04904536	OLT	3	LC
2024-12-31	D	Prednisolone	cognitive	NCT05986422	RCT	2	PC
2024-12-31	S	Cacao flavonoid	fatigue, handgrip strength, perceived wellbeing	NCT06064838	OLT	n/a	LC
2024-12-31	S	Melatonin & Zinc	many	NCT05454683	RCT	n/a	ME
2024-12-31	R	Cardiopulmonary exercise	cardiopulmonary	NCT05539950	RCT	n/a	PC, ME
2024-12-31	S	Sodium citrate	parosmia	NCT06204432	RCT	2	PC
2024-12-31	R	Physical exercise	many	NCT05094622	OLT	n/a	PC, ME
2024-12-31	S	Floradapt Intensive GI (Probiotic)	GI inflammation, many	NCT06211062	RCT	2	ME
2024-12-31	R	Interrupted sitting	PEM, cognitive, quality of life	NCT05453175	RCT	n/a	LC
2025-01-15	R	Chiropractic	fatigue	NCT05693064	RCT	n/a	LC
2025-01-30	O	Repeat immunoadsorption	many	NCT05629988	OLT	n/a	PC, ME
2025-01-31	O	CPAP	fog, neuropsychological	NCT06052514	OLT	n/a	PC
2025-01-31	S	Nicotinamide riboside & MBRT	many	NCT05703074	RCT	2	LC
2025-01-31	O	TDCS	many	NCT05791812	OLT	n/a	ME
2025-02-15	O	Umbilical cord mesenchymal stem cell therapy	caugh	NCT05808400	NRCT	n/a	LC
2025-02-28	O	Immunoadsorption	many	NCT05710770	RCT	2	PC, ME
2025-02-28	S	Nitrate	physical fatigue	NCT05618574	OLT	3	LC
2025-02-28	D	DAOIB	cognitive	NCT05764538	OLT	2	LC
2025-02-28	O	Cognitive training (online)	cognitive	NCT06391489	OLT	n/a	LC, PC
2025-03-01	O	Vagus nerve stimulation	many	NCT05918965	OLT	n/a	LC
2025-03-30	P	CBT & CRT	many	NCT05732285	OLT	n/a	many
2025-03-31	O	Mild hyperthermia	many	NCT06204458	RCT	n/a	PC
2025-03-31	S	Immulina TM (supplement)	many	NCT05524532	RCT	n/a	PC, ME
2025-03-31	O	Apollo wearable	many	NCT06097442	OLT	n/a	LC
2025-04-15	P	Vimida (app)	fatigue, depression, anxiety, quality of life, ...	NCT06251518	RCT	n/a	PC
2025-04-30	C	Electro-acupuncture	many	NCT05890508	RCT	n/a	LC
2025-04-30	P	Mindfulness	mental health	NCT05676008	OLT	n/a	LC
2025-04-30	S	N-acetylcysteine	many	NCT0454216	RCT	2	ME
2025-05-15	D	Amantadine	cognitive, mood	NCT06055244	OLT	1	PC
2025-05-15	D	Fluvoxamine	many	NCT05874037	RCT	2/3	LC
2025-05-18	D	Fluvoxamine & Metformin	fatigue	NCT06128967	RCT	3	LC
2025-05-31	D	BC007	many	NCT05911009	RCT	2	PC
2025-05-31	D	Efgartigimod	POTS	NCT05918978	OLT	2	PC
2025-06-01	S	Pycnogenol	many	NCT05890534	RCT	3	PC
2025-06-01	R	Physical exercise	many	NCT05877534	RCT	n/a	PC
2025-06-30	R	Physical exercise	cardiovascular	NCT06168006	RCT	n/a	PC
2025-07-19	C	Acupuncture	fatigue	NCT05212688	RCT	2	LC
2025-07-30	O	Diet & fasting	many	NCT06214455	OLT	n/a	LC
2025-07-31	D	AER002	many	NCT05877508	RCT	2	LC
2025-07-31	R	Physical exercise (sensors + app)	fitness, quality of life	NCT05922865	OLT	n/a	LC
2025-07-31	D	Modafinil & Solriamfetol & Melatonin & tailored lighing	sleep	NCT06404086	RCT	2	LC, PC
2025-08-31	O	Vagus nerve stimulation	fatigue	NCT06170645	RCT	n/a	ME
2025-08-31	O	Hyperbaric oxygen therapy	neurocognitive	NCT06118138	OLT	n/a	PC
2025-08-31	D	Anakinra	respiratory	NCT05926505	RCT	2/3	LC, PC
2025-08-31	O	Stellate ganglion block	parosmia	NCT06255600	RCT	2	PC
2025-09-01	D	VIX001	cognitive, neurological	NCT05947617	OLT	1	LC, PC
2025-09-01	R	Physical exercise	fatigue, fitness	NCT06142240	OLT	n/a	LC
2025-09-30	P	Balance acceptance and commitment	many	NCT06231238	RCT	2	LC, PC
2025-09-30	R	Supervised computerized active program	cognitive, emotional, functional	NCT06315894	OLT	n/a	LC, PC
2025-10-31	D	Melatonin & lighting	sleep	NCT06404112	RCT	2	LC, PC
2025-11-01	S	Ciwujia granules	many	NCT06245642	RCT	4	ME
2025-11-01	S	Testofen	many	NCT05795816	RCT	3	LC
2025-11-30	D	Modafinil & Solriamfetol	sleep	NCT06404099	RCT	2	LC, PC
2025-12-01	R	Physical and cognitive exercising	many	NCT05218174	RCT	n/a	LC, PC
2025-12-01	D	Amantadine	cognitive, fatigue, anxiety, depression	NCT06234462	RCT	2	LC
2025-12-01	D	Remdesivir	many	NCT05911906	RCT	4	LC
2025-12-15	O	IVIG (immunotherapy)	neurological	NCT05350774	RCT	2	PC
2025-12-20	O	HB-adMSCs (allogeneic)	many	NCT05126563	RCT	2	PC
2025-12-30	O	Hyperbaric oxygen therapy	many	NCT06082518	OLT	n/a	PC
2025-12-31	O	IVIG	many	NCT06159283	RCT	2	LC, PC
2025-12-31	R	Water-based activity	fatigue, cognitive	NCT06142253	OLT	n/a	LC
2025-12-31	D	Imatinib / Infliximab	many	NCT05220280	OLT	4	LC
2025-12-31	R	Rehabilitation & exercise	fatigue	NCT06156176	RCT	n/a	LC, PC
2025-12-31	D	Ensitrelvir	many	NCT06161688	RCT	2	LC
2025-12-31	C	Complementary & Integrative medicine online	many	NCT06004362	RCT	n/a	PC
2025-12-31	D	Ibudilast	many	NCT05513560	RCT	3	PC
2026-01-31	R	Cardiopulmonary rehabilitation	many	NCT06404060	OLT	n/a	LC, PC
2026-01-31	R	Pacing	many	NCT06404073	OLT	n/a	LC, PC
2026-01-31	P	Mind body intervention	many	NCT06045338	OLT	n/a	LC
2026-02-28	C	TCM	many	NCT06095258	RCT	2	LC
2026-02-28	O	Stem cell therapy	neurological	NCT06156241	OLT	1	LC
2026-03-01	S	MCTs & Safflower oil	fog	NCT05705648	RCT	n/a	PC
2026-03-30	R	Comprehensive rehabilitation	fatigue	NCT06156202	RCT	n/a	LC
2026-03-31	D	AT1001 (Larazotide)	many	NCT05747534	RCT	2	LC
2026-03-31	D	Lp299v	many	NCT05227170	RCT	n/a	LC, PC
2026-04-01	O	Hyperbaric oxygen therapy	many	NCT06267300	RCT	3	PC
2026-04-01	P	Lightning Process	many	NCT05236465	OLT	n/a	ME
2026-04-28	D	Nirmatrelvir & ​Ritonavir (Paxlovid)	many	NCT05852873	RCT	3	PC
2026-05-15	O	Stellate ganglion block	parosmia	NCT06055270	RCT	3	PC
2026-06-01	R	Breath control technique	many	NCT05851859	OLT	n/a	LC
2026-06-11	D	Rapamycin	many	NCT06257420	OLT	n/a	ME
2026-06-30	D	Pyridostigmine & Low dose naltrexone	PEM, pain, overall health	NCT06366724	RCT	2	ME
2026-08-01	R	Incentive spirometrer respiratory training	respiratory	NCT06231225	OLT	n/a	LC
2026-12-01	O	Diet & self-management (online)	many	NCT05057676	OLT	n/a	many
2026-12-31	D	Low dose naltrexone	POTS	NCT05363514	RCT	4	n/a
2028-01-31	R	Smell training and trigeminal nerve stimulation	parosmia	NCT05855369	RCT	2/3	LC, PC
2028-03-01	D	Pregabalin	many	NCT05967052	RCT	2	ME
2028-09-30	O	Weight loss	fitness	NCT05880108	RCT	n/a	LC
2028-09-30	O	Anti-inflammatory diet	fatigue, fitness	NCT05977179	RCT	n/a	LC, PC
2029-03-31	R	Cognitive rehabilitation	many	NCT06086379	RCT	n/a	LC, PC
2029-12-30	D	Baricitinib	cognitive	NCT05858515	RCT	2	PC