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Lithium

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Lithium inhibits microglial activation via the toll-like receptor 4 (TLR4).[1]

References[edit | edit source]

  1. ↑ Dong, Hongquan; Zhang, Xiang; Dai, Xiaonan; Lu, Shunmei; Gui, Bo; Jin, Wenjie; Zhang, Susu; Zhang, Shu; Qian, Yanning (August 14, 2014), "Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway", Journal of Neuroinflammation, 11: 140, doi:10.1186/s12974-014-0140-4, ISSN 1742-2094, PMC 4149204, PMID 25115727

microglia A type of immune cell, called a macrophage, that lives in the brain. For historical reasons, macrophages have different names based on the part of the body that they normally live in. Macrophages that normally live in the blood are called monocytes. Macrophages that normally live in the skin are called Langerhans cells. Macrophages that normally live in the liver are called Kupffer cells. And macrophages that normally live in the central nervous system are called microglia. Microglia were originally classified as glial cells, under the assumption that the cells had a merely structural function, before it was realized that the cells were in fact immune cells. As the "sentinel cells" of the central nervous system, microglia survey their environment for abnormalities such as infection or tissue damage, and then initiate an immune response to fight the infection or repair the tissue damage.

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