TLR4 (Toll-like receptor 4) is one of ten toll-like receptors.
TLR4 is upregulated in ME/CFS patients.
Coxsackie B4 triggers TLR4 on human pancreatic cells, TLR4 knock-out mice infected with Coxsackie B3 showed reduced myocarditis and viral replication.
Low-dose naltrexone (LDN), lithium, and oxymatrine inhibit microglial activation via TLR4.
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