Glial cell

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Neuroglia

Glial cells, commonly called neuroglia or simply glia, are one of two major classes of cells in neural tissues, the other being neurons. Glia, which is Greek for glue, have traditionally been viewed as the glue that holds the neuronal system together, representing the historical view that glia exist to provide support to neurons. However, the type of glia known as microglia was subsequently found to actually be a tissue-resident macrophage, an immune cell. There is also increasing evidence that the type of glia known as astrocytes may play a more active role in brain function, by influencing and perhaps directing the activity of neurons (SFN 2000)."[1]

Glial activation[edit | edit source]

Glasson (2017) described the following model showing the effects of sustained glial activation.

Effects of sustained glial activation Source: Glassford JAG (2017) The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front. Physiol. 8:88.[2]

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Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.