Dorsal root ganglia
Dorsal root ganglia (DRG) is "a nodule in a dorsal root that contains cell bodies of neurons in afferent spinal nerves." They lie along the posterior of the vertebral column by the spine. The dorsal root ganglia "contain the cell bodies of afferent nerve fibres (those carrying impulses toward the central nervous system); efferent neurons (carrying motor impulses away from the central nervous system) are present in the ventral root ganglia."
The neuron is parted of two parts:
- Dendrite receives the information and sends it to the Perykaron (cytoplasm which is around the nucleus).
- Axon takes this information and sends forward.
In human disease[edit | edit source]inflammation of a nerve ganglion. The dorsal root ganglia can become inflamed causing severe pain and other symptoms. Conditions that can cause dorsa root ganglionitis include trauma, sciatica, compressive neuropathy, herniated disc, spinal stenosis, peripheral neuropathy, meningitis, and spinal infections, including Herpes simplex virus 1.
ME/CFS[edit | edit source]
Inflammation of the dorsal root ganglia (ganglionitis) has been found in the autopsies of several very severely ill myalgic encephalomyelitis patients including Lynn Gilderdale, Sophia Mirza and Merryn Crofts.
Sjogren’s syndrome[edit | edit source]
13 Sjogren’s patients with autonomic dysfunction were found to have lymphocytic (T‐cell) infiltration in the dorsal roots and ganglia, Electrophysical studies also found involvement of the dorsal root ganglia. Antiganglion autoantibodies have been detected in patients with sensory neuropathy.
Learn more [edit | edit source]
- 2006, Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons.
- 2013, dorsal root ganglionitis: Kay Gilderdale writes of her late, severely affected, daughter:
- 2014, Inflammation in dorsal root ganglia after peripheral nerve injury: Effects of the sympathetic innervation
- 2015, Herpes Simplex Virus Type 1 Dorsal Root Ganglionitis in a 34 Year Old Male With Occipital Neuralgia Refractory to Medical and Radiofrequency Ablation Therapies: A Clinicopathological Report and Literature Review (P1.293)
- 2015, Dorsal Root Ganglionitis - infection of inflammation?
- Dorsal root ganglion: Wikis Images and diagrams.
- Histology Photomicrographs
- Shotgun Histology Dorsal Root Ganglion Video
- Slide 42 - Dorsal Root Sensory Ganglion Video explanation of histology slide
See also[edit | edit source]
References[edit | edit source]
- "Dorsal root ganglia : Wikis (The Full Wiki)". www.thefullwiki.org. Retrieved Aug 13, 2018.
- "Ganglion | physiology". Encyclopedia Britannica. Retrieved Aug 13, 2018.
- "Dendrite". Wikipedia. Jun 6, 2018.
- "Axon". Wikipedia. Jul 23, 2018.
- Ma, C.; Greenquist, K. W.; Lamotte, R. H. (Apr 2006). "Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons". Journal of Neurophysiology. 95 (4): 2098–2107. doi:10.1152/jn.00748.2005. ISSN 0022-3077. PMID 16381809.
- "Dorsal Root Ganglion - RightDiagnosis.com". www.rightdiagnosis.com. Retrieved Aug 16, 2018.
- Slavin, Konstantin V.; Jain, Paavani; Rathore, Ranvir S.; Rakic, Andrei M.; Rathore, Jaivir S.; Valyi-Nagy, Tibor (2017). "Herpes Simplex Virus Type 1 Human Cervical Dorsal Root Ganglionitis". Case Reports in Neurology. 9 (2): 188–194. doi:10.1159/000479146. ISSN 1662-680X. PMID 28966586.
- Wilkinson, Damon (Apr 1, 2018). "'Bed-bound and in unimaginable pain, watching my daughter waste away and die from ME was torture'". men. Retrieved Aug 16, 2018.
- Mirza, Sophia (Nov 15, 2005). "Certified Copy of an Entry - Death". sophiaandme.org.uk. City and County of Brighton and Hove.
- Dr. Speedy (Apr 16, 2011). "Lynn Gilderdale's autopsy showed 'dorsal root ganglionitis' - infected nerve roots, just like Sophia Mirza's". niceguidelines.blogspot.com.
- Malinow, K.; Yannakakis, G. D.; Glusman, S. M.; Edlow, D. W.; Griffin, J.; Pestronk, A.; Powell, D. L.; Ramsey‐Goldman, R.; Eidelman, B. H. (1986). "Subacute sensory neuronopathy secondary to dorsal root ganglionitis in primary Sjögren's syndrome". Annals of Neurology. 20 (4): 535–537. doi:10.1002/ana.410200416. ISSN 1531-8249.
- Ma, C.; Greenquist, K. W.; Lamotte, R. H. (2006). "Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons". Journal of Neurophysiology. 95 (4): 2098–2107. doi:10.1152/jn.00748.2005. ISSN 0022-3077. PMID 16381809.
- "dorsal root ganglionitis - Kay Gilderdale writes of her late, severely affected, daughter:". talkhealthpartnership.com. Aug 14, 2013.
- "Inflammation in dorsal root ganglia after peripheral nerve injury: Effects of the sympathetic innervation". Autonomic Neuroscience. 182: 108–117. May 1, 2014. doi:10.1016/j.autneu.2013.12.009. ISSN 1566-0702.
- Rathore, Jaivir; Slavin, Konstantin; Rathore, Ranvir; Rakic, Andrei; Valyi-Nagy, Tibor (Apr 6, 2015). "Herpes Simplex Virus Type 1 Dorsal Root Ganglionitis in a 34 Year Old Male With Occipital Neuralgia Refractory to Medical and Radiofrequency Ablation Therapies: A Clinicopathological Report and Literature Review (P1.293)". Neurology. 84 (14 Supplement): P1.293. ISSN 0028-3878.
- "Dorsal Root Ganglionitis - infection of inflammation?". Phoenix Rising ME / CFS Forums. Retrieved Aug 16, 2018.
- Hart, Karen. "Histology Photomicrographs - Dorsal root ganglion". eugraph.com. Retrieved Aug 13, 2018.
- "Shotgun Histology Dorsal Root Ganglion". YouTube. WashingtonDeceit. Aug 23, 2007.
- Larsen, Stephen (Apr 2, 2010). "Slide 42 - Dorsal Root Sensory Ganglion". YouTube. DrStephenLarsen.
Antibody - Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.