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Valaciclovir (UK) or valacyclovir (US) is a generic antiviral drug used against most herpesviruses. It does not cure herpes, but helps reduce the viral expression, by interrupting the replication of viral DNA.[1]

Valaciclvir is the international nonproprietary name used by the World Health Organization (WHO). The non-generic or trade names are Valtrex and Zelitrex, manufactured by GlaxoSmithKline.

It is available by prescription only, worldwide, and is administered orally.

Once in the body, valaciclovir is converted to aciclovir (UK) or acyclovir (US).

Treatment with Valacyclovir reduces the number of Epstein-Barr virus-infected B cells, but not the number of EBV DNA copies within each infected cell.[2]

Use in ME/CFS[edit | edit source]

Some ME/CFS specialists prescribe valaciclovir to help mitigate the effects of the Epstein-Barr virus which may be reactivated in ME/CFS. Dr. A Martin Lerner studied the efficacy of higher doses of Valtrex on ME/CFS and concluded that it increased physical functioning, improved heart functioning, and decreased Epstein-Barr virus antibody levels. [3]

Valtrex inhibits the replication of HH-1, HH-2, HH-3, HH-4, HH-5 (Herpes simplex, Herpes Zoster, EBV, CMV) and has seen improvements in 85% of ME/CFS patients. Among adolescents, the outcome was even better with 92% responding. Only one patient experienced nausea and discontinued the antiviral. Improvement occurred over the course of 3-5 months with 85% percent of the patients responding by 3 months, and 92% by 5 months. Symptoms of fatigue, exertion induced malaise, excessive sleep, napping, unrefreshing sleep, headaches, cognitive symptoms, and emotional symptoms all resolved.[4][5]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Wikipedia - Valaciclovir
  2. Hoshino, Yo; Katano, Harutaka; Zou, Ping; Hohman, Patricia; Marques, Adriana; Tyring, Stephen K.; Follmann, Dean; Cohen, Jeffrey I. (November 2009), "Long-Term Administration of Valacyclovir Reduces the Number of Epstein-Barr Virus (EBV)-Infected B Cells but Not the Number of EBV DNA Copies per B Cell in Healthy Volunteers", Journal of Virology, 83 (22): 11857–11861, doi:10.1128/JVI.01005-09, ISSN 0022-538X, PMC 2772668, PMID 19740997, retrieved November 9, 2016
  3. "Dr. Martin Lerner's Treatment Protocol for ME/CFS". CFS Treatment Guide. Retrieved October 8, 2020.
  4. Henderson, Theodore A. “Valacyclovir treatment of chronic fatigue in adolescents.” Advances in mind-body medicine vol. 28,1 (2014): 4-14.
  5. The Role of Antiviral Therapy in Chronic Fatigue Treatment, Theodore Henderson, MD, PhD, March 2015

World Health Organization (WHO) - "A specialized agency of the United Nations that is concerned with public health. It was established on 7 April 1948, and is headquartered in Geneva, Switzerland. The WHO is a member of the United Nations Development Group. Its predecessor, the Health Organization, was an agency of the League of Nations." The International Statistical Classification of Diseases and Related Health Problems (ICD) is maintained by WHO.

antibodies Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

cytomegalovirus (CMV) - A common herpesvirus found in humans. Like other herpesviruses, it is a life-long infection that remains in a latent state inside the human body, until it is 'reactivated' by appropriate conditions. CMV infects between 60% to 70% of adults in industrialized countries and close to 100% in emerging countries. Much is unknown about this virus, although it has been found in salivary glands and myeloid blood cells such as monocytes. It has also been linked to the development of certain cancers. Congenital CMV is a leading infectious cause of deafness, learning disabilities, and intellectual disability. A common treatment for CMV is valganciclovir, commonly known as Valcyte.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.