From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Oxaloacetate or oxaloacetic acid (OAA) or Anhydrous Enol-Oxaloacetate or (AEO), also available under the brand name Jubilance, is nutritional supplement currently under investigation as a treatment for chronic fatigue and mental fatigue in ME/CFS[1] and Long COVID.[2] The Jubilance brand has limited evidence that it "may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with Premenstrual Syndrome (PMS)".[3]

Theory[edit | edit source]

Oxaloacetate is produced by the body, and additional oxaloacetate may provide mitochondria support in ME/CFS.[citation needed]

Evidence[edit | edit source]

In 2022, Cash et al. (2022) reported:

"Anhydrous Enol-Oxaloacetate, (AEO) a nutritional supplement, has been anecdotally reported to relieve physical and mental fatigue and is dimished in ME/CFS patients. Here, we examine the use of higher dosage AEO as a medical food to relieve pathological fatigue."

"76 ME/CFS patients (73.7% women, median age of 47) showed an average reduction in fatigue at 6 weeks as measured by the "Chalder Fatigue Questionnaire" of 22.5% to 27.9% from baseline (P < 0.005) (Likert scoring).

Clinicians[edit | edit source]

Risks and safety[edit | edit source]

Costs and availability[edit | edit source]

Notable studies[edit | edit source]

  • 2022, Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial[4] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]