Oxaloacetate
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Oxaloacetate or oxaloacetic acid (OAA) or Anhydrous Enol-Oxaloacetate or (AEO), also available under the brand name Jubilance, is nutritional supplement currently under investigation as a treatment for chronic fatigue and mental fatigue in ME/CFS[1] and Long COVID.[2] The Jubilance brand has limited evidence that it "may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with Premenstrual Syndrome (PMS)".[3]
Theory
Oxaloacetate is part of the Citric acid cycle and is formed from pyruvate. It is crucial in replenishing the citric acid cycle by acting as an acceptor for Acetyl coenzyme A.[4] Additional oxaloacetate may provide mitochondrial support in ME/CFS.[citation needed]
Evidence
In 2022, Cash et al. (2022) reported:
- "Anhydrous Enol-Oxaloacetate, (AEO) a nutritional supplement, has been anecdotally reported to relieve physical and mental fatigue and is dimished in ME/CFS patients. Here, we examine the use of higher dosage AEO as a medical food to relieve pathological fatigue."
"76 ME/CFS patients (73.7% women, median age of 47) showed an average reduction in fatigue at 6 weeks as measured by the "Chalder Fatigue Questionnaire" of 22.5% to 27.9% from baseline (P < 0.005) (Likert scoring).
Clinicians
Risks and safety
Costs and availability
Notable studies
- 2022, Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial[5] - (Full text)
See also
Learn more
References
- ↑ Terra Biological LLC; Bateman Horne Center (February 28, 2022). "A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS". ClinicalTrials.gov. Retrieved August 29, 2022.
- ↑ Terra Biological LLC (October 16, 2020). "Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors". clinicaltrials.gov.
- ↑ Tully, Lisa; Humiston, John; Cash, Alan (March 2020). "Oxaloacetate reduces emotional symptoms in premenstrual syndrome (PMS): results of a placebo-controlled, cross-over clinical trial". Obstetrics & Gynecology Science. 63 (2): 195–204. doi:10.5468/ogs.2020.63.2.195. ISSN 2287-8572. PMC 7073356. PMID 32206660.
- ↑ Rabinowitz, Joshua; Tompkins, Sean; Taylor, Eric (December 21, 2013). "Regulation of pyruvate metabolism and human disease". Cell Mol Life Sci. 71 (14): 2577–2604. doi:10.1007/s00018-013-1539-2. PMC 4059968. PMID 24363178.
- ↑ Cash, Alan; Kaufman, David Lyons (June 28, 2022). "Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial". Journal of Translational Medicine. 20 (1): 295. doi:10.1186/s12967-022-03488-3. ISSN 1479-5876. PMC 9238249. PMID 35764955.
