Canadian Consensus Criteria

The Canadian consensus criteria (CCC) or the Canadian working definition are a proposed clinical criteria for ME/CFS, published in 2003, and frequently used as a case definition in research. The Canadian definition is a strictest diagnostic criteria, selecting a smaller group of patients than the Fukuda criteria and a more severely impaired population. Adults are diagnosed after a minimum of six months of illness and children after a minimum of three months.

Definition

Canadian Consensus Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

A patient with ME/CFS will meet the criteria for fatigue, post-exertional malaise and/or fatigue, sleep dysfunction and pain; have two or more neurological/cognitive manifestations and one or more symptoms from two of the categories of (a) autonomic, (b) neuroendocrine and (c) immune manifestations; and adhere to item 7.
1	Fatigue Required	The patient must have a significant degree of new onset, unexplained, persistent, or recurrent physical and mental fatigue that substantially reduces activity level.
2	Post-Exertional Malaise and/or Post-Exertional Fatigue Required	There is an inappropriate loss of physical and mental stamina, rapid muscular and cognitive fatigability, post-exertional malaise and/or post-exertional fatigue and a tendency for other associated symptoms within the patient’s cluster of symptoms to worsen. There is a pathologically slow recovery period – usually 24 hours or longer.
3	Sleep Dysfunction (*) Required	There is unrefreshing sleep or sleep quantity or rhythm disturbances such as reversed or chaotic diurnal sleep rhythms. Note that patients without sleep dysfunction can still meet the diagnostic criteria if their illness began with an infection — see (*) below.
4	Pain (*) Required	There is a significant degree of myalgia. Pain can be experienced in the muscles, and/or joints, and is often widespread and migratory in nature. Often there are significant headaches of new type, pattern or severity. Note that patients without pain can still meet the diagnostic criteria if their illness began with an infection — see (*) below.
5	Neurological / Cognitive Manifestations Two or more	Two or more of the following difficulties should be present:  Confusion Impairment of concentration and short-term memory consolidation Disorientation Difficulty with information processing, categorizing and word retrieval (word-finding problems) Perceptual and sensory disturbances (for example spatial instability and disorientation and inability to focus vision) Ataxia, muscle weakness and fasciculations are common. There may be overload1 phenomena: cognitive overload, sensory overload (for example photophobia and hypersensitivity to noise) and/or emotional overload, which may lead to crash2 periods and/or anxiety.
6	At Least One Symptom From Two of the Following Three Categories (autonomic, neuroendocrine, immune)	At Least One Symptom From Two of the Following Three Categories:
		(a) Autonomic Manifestations Orthostatic intolerance (either neurally mediated hypotension, postural orthostatic tachycardia syndrome or delayed orthostatic hypotension) Light-headedness Extreme pallor Nausea and irritable bowel syndrome Urinary frequency and bladder dysfunction Heart palpitations with or without cardiac arrhythmias Exertional dyspnea
		(b) Neuroendocrine Manifestations Loss of thermostatic stability (subnormal body temperature and marked diurnal fluctuation) Sweating episodes, recurrent feelings of feverishness cold extremities (cold hand and feet) Intolerance of extremes of heat and cold Marked weight change (anorexia or abnormal appetite) Loss of adaptability and worsening of symptoms with stress
		(c) Immune Manifestations Tender lymph nodes Recurrent sore throat Recurrent flu-like symptoms General malaise New food sensitivities, medication sensitivities and/or chemical sensitivities
7	The Illness Persists for at Least Six Months Required	It usually has a distinct onset, (**) although it may be gradual. Preliminary diagnosis may be possible earlier. Three months is appropriate for children.

To be included, the symptoms must have begun or have been significantly altered after the onset of this illness. It is unlikely that a patient will suffer from all symptoms in criteria 5 & 6. The disturbances tend to form symptom clusters that may fluctuate and change over time. Children often have numerous prominent symptoms but their order of severity tends to vary from day to day.

(*) There is a small number of patients who have no pain or sleep dysfunction, but no other diagnosis fits except ME/CFS. A diagnosis of ME/CFS can be entertained when this group has an infectious illness type onset.

(**) Some patients have been unhealthy for other reasons prior to the onset of ME/ CFS and lack detectable triggers at onset or have more gradual or insidious onset.

1"Overload" refers to hypersensitivities to stimuli that have changed from pre-illness status.

2 "Crash" refers to a temporary period of immobilizing physical and /or cognitive fatigue.

Idiopathic chronic fatigue

People with chronic fatigue (lasting at least six months) but not meeting the criteria for ME/CFS should be diagnosed with idiopathic chronic fatigue instead.

Authors

Bruce Carruthers, Anil Kumar Jain, Kenny de Meirleir, Daniel Peterson, Nancy Klimas, A Martin Lerner, Alison Bested, Pierre Flor-Henry, Pradip Joshi, A C Peter Powles, Jeffrey Sherkey, Marjorie van de Sande

Diagram of ME/CFS symptoms

Simplified diagram of ME/CFS Canadian consensus criteria symptoms

See also

• Case Definition Comparison - Graph 1
• Definitions of ME and CFS
• International Consensus Criteria

Generally accepted criteria for diagnosis

• Canadian consensus criteria (CCC). A diagnosis of moderate and severe forms of ME/CFS are accurately made using these criteria. Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.
• International consensus criteria (ICC). These criteria will accurately diagnose myalgic encephalomyelitis (ME). There is no requirement that the individual have symptoms for a specified period of time for diagnosis, as opposed to CCC, Fukuda, and SEID, which all require 6 months in adults.
• CDC Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2017 diagnostic criteria - originally known as the Systemic exertion intolerance disease (SEID) criteria ME/CFS (SEID) is accurately diagnosed when the core symptoms are met. The Institute of Medicine report as a whole is a comprehensive review of the medical literature available at time of publication (2015). Adults can be diagnosed at 6 months while pediatric cases are diagnosed at three months.

Learn more

• A Clinical Case Definition and Guidelines for Medical Practitioners - An Overview of the Canadian Consensus Document (the above 7 criteria are listed on page 2 of this document).
• Canadian Consensus Report - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols (full version of the Canadian consensus criteria).
• An Overview of the Canadian Consensus Document in French - Encéphalomyélite myalgique/syndrome de fatigue chronique: Définition clinique et lignes directrices à l’intention des médecins, Abrégé du Consensus canadien

See Canadian consensus criteria.

Canadian Consensus Criteria (CCC) - A set of diagnostic criteria used to diagnose ME/CFS, developed by a group of practicing ME/CFS clinicians in 2003. The CCC is often considered to be the most complex criteria, but possibly the most accurate, with the lowest number of patients meeting the criteria. Led to the development of the International Consensus Criteria (ICC) in 2011.

Canadian Consensus Criteria (CCC) - A set of diagnostic criteria used to diagnose ME/CFS, developed by a group of practicing ME/CFS clinicians in 2003. The CCC is often considered to be the most complex criteria, but possibly the most accurate, with the lowest number of patients meeting the criteria. Led to the development of the International Consensus Criteria (ICC) in 2011.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

relating to hormones that influence the nervous system

neuroendocrine relating to hormones that influence the nervous system

See myalgic encephalomyelitis.

See chronic fatigue syndrome.

cognition Thought processes, including attention, reasoning, and memory.

Canadian Consensus Criteria (CCC) - A set of diagnostic criteria used to diagnose ME/CFS, developed by a group of practicing ME/CFS clinicians in 2003. The CCC is often considered to be the most complex criteria, but possibly the most accurate, with the lowest number of patients meeting the criteria. Led to the development of the International Consensus Criteria (ICC) in 2011.

International Consensus Criteria (ICC) - A set of diagnostic criteria, based on the Canadian Consensus Criteria, that argued for the abandonment of the term "chronic fatigue syndrome" and encouraged the sole use of the term "myalgic encephalomyelitis".

See International Consensus Criteria.

systemic exertion intolerance disease (SEID) - A term for ME/CFS that aims to avoid the stigma associated with the term "chronic fatigue syndrome", while emphasizing the defining characteristic of post-exertional malaise (PEM). SEID was defined as part of the diagnostic criteria put together by the Institute of Medicine (IOM) report of 10 February 2015.

See systemic exertion intolerance disease.