Michael Shelanski

Source:sklad.cumc.columbia.edu

Michael Shelanski, M.D., Ph.D., was a panel member and contributed his expertise to the February 2015, Institute of Medicine report, Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Redefining an Illness.

The following biographical sketch is from Appendix E of the Institute of Medicine report, Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness.

"Michael Shelanski, M.D., Ph.D., serves as chairman of the department of pathology and cell biology at Columbia University, co-director of the Taub Institute, and director of the Medical Scientist Training Program. He is a member of the American Society for Cell Biology, the American Society for Investigative Pathology, the Association of American Physicians, and the IOM. Dr. Shelanski’s laboratory has been responsible for the identification and purification of several of the major cytoskeletal proteins and has served as a training ground for a number of outstanding scholars of the neurodegenerations. The laboratory is using a combination of cell biological and molecular biological approaches to unravel the pathways of “cell suicide” or apoptosis in Alzheimer’s disease and other neurodegenerations, to understand the alterations in gene expression that occur in these diseases, and to dissect the regulation of synaptic responses in these diseases."

Honors and Awards

• 1970-1971, 1973-1974 National Institute of Neurological Disorders and Stroke Teacher-investigator Award
• 1973-1974 Guggenheim Foundation Fellow
• 1995-2001 Jacob Javits Neuroscience Investigator Award
• 1999-present Member, Institute of Medicine, National Academy of Sciences
• 2013- Distinguished Service Award from the University of Chicago

See also

• Columbia University Research Faculty Biography

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).

See National Academy of Medicine.

a type of cell death in which a cell, in response to a threat, initiates a series of molecular steps that lead to its orderly death. This is one method the body uses to get rid of unneeded or abnormal cells. This form of cell suicide is also called programmed cell death.

apoptosis a type of cell death in which a cell, in response to a threat, initiates a series of molecular steps that lead to its orderly death. This is one method the body uses to get rid of unneeded or abnormal cells. This form of cell suicide is also called programmed cell death.

National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).