Michael Shelanski

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Source:sklad.cumc.columbia.edu

Michael Shelanski, M.D., Ph.D., was a panel member and contributed his expertise to the February 2015, Institute of Medicine report, Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Redefining an Illness.

The following biographical sketch is from Appendix E of the Institute of Medicine report, Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. [1]

"Michael Shelanski, M.D., Ph.D., serves as chairman of the department of pathology and cell biology at Columbia University, co-director of the Taub Institute, and director of the Medical Scientist Training Program. He is a member of the American Society for Cell Biology, the American Society for Investigative Pathology, the Association of American Physicians, and the IOM. Dr. Shelanski’s laboratory has been responsible for the identification and purification of several of the major cytoskeletal proteins and has served as a training ground for a number of outstanding scholars of the neurodegenerations. The laboratory is using a combination of cell biological and molecular biological approaches to unravel the pathways of “cell suicide” or apoptosis in Alzheimer’s disease and other neurodegenerations, to understand the alterations in gene expression that occur in these diseases, and to dissect the regulation of synaptic responses in these diseases."[2]

Honors and Awards[edit | edit source]

  • 1970-1971, 1973-1974 National Institute of Neurological Disorders and Stroke Teacher-investigator Award
  • 1973-1974 Guggenheim Foundation Fellow
  • 1995-2001 Jacob Javits Neuroscience Investigator Award
  • 1999-present Member, Institute of Medicine, National Academy of Sciences
  • 2013- Distinguished Service Award from the University of Chicago

See also[edit | edit source]

References[edit | edit source]

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).

apoptosis - a type of cell death in which a cell, in response to a threat, initiates a series of molecular steps that lead to its orderly death. This is one method the body uses to get rid of unneeded or abnormal cells. This form of cell suicide is also called programmed cell death.

National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).

The information provided at this site is not intended to diagnose or treat any illness.
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