Case Definition Comparison - Graph 1

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Individuals referred by medical specialists in CFS and ME-CFS .png

Source:Chronic Fatigue Syndrome and Myalgic Encephalomyelitis: Toward An Empirical Case Definition,[1]

See also[edit | edit source]

Definitions of ME and CFS

Reference[edit | edit source]

  1. Jason, L. A., Kot, B., Sunnquist, M., Brown, A., Reed, J., Furst, J., ... & Vernon, S. D. (2015). Comparing and contrasting consensus versus empirical domains. Fatigue: biomedicine, health & behavior, 3(2), 63-74. doi:10.1080/21641846.2015.1017344 Retrieved from

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.