Q fever, also called query fever, is a zoonotic disease that causes both acute or chronic phases in humans. The infectious agent, the Coxiella burnetii bacterium, is acquired after contact with infected animals, especially goats, sheep, and cattle, or exposure to environments contaminated with the urine, feces or amniotic fluid of infected animals.
Symptoms[edit | edit source]
The acute symptoms usually develop within 2-3 weeks of exposure, although as many as half of humans infected with C. burnetii do not show symptoms. The combination of symptoms varies greatly from person to person, but often present as: high fevers (up to 104-105°F), severe headache, general malaise, myalgia, chills and/or sweating episodes, non-productive cough, nausea, vomiting, diarrhea, abdominal pain, and chest pain. Complications with serious cases may include pneumonia, granulomatous hepatitis (inflammation of the liver), myocarditis (inflammation of the heart tissue), central nervous system complications, and pre-term delivery or miscarriage.
Chronic Q fever may present within 6 weeks after an acute infection or may manifest months or years later. The three groups at highest risk for chronic Q fever are pregnant women, immunosuppressed persons and patients with a pre-existing heart valve defects. Although the majority of people with acute Q fever recover completely, a post-Q fever fatigue syndrome (QFS) has been reported to occur in 10-25% of acute patients. This syndrome is characterized by constant or recurring fatigue, night sweats, severe headaches, photophobia (eye sensitivity to light), pain in muscles and joints, mood changes, and difficulty sleeping.
ME/CFS[edit | edit source]
Q fever is known to trigger chronic fatigue in some patients, often referred to as Q Fever Fatigue Syndrome (QFS).
A 2006 prospective study found that 11% of subjects infected with Q fever met the criteria for chronic fatigue syndrome six months after their infection. (The same rate held true for Epstein-Barr virus and Ross River virus). In a 2015 study, QFS patients were compared with chronic fatigue syndrome (CFS) patients: "In all analyses QFS patients were as fatigued and distressed as CFS patients, but reported less additional symptoms. QFS patients had stronger somatic attributions, and higher levels of physical activity. No differences were found with regard to inflammatory markers and in other fatigue-related cognitive-behavioral variables."
A 2020 study done in the Netherlands studied patterns of the gut microbiome, blood metabolome, and inflammatory proteome of QFS patients, and compared these with those of chronic fatigue syndrome (CFS) patients and healthy controls (HC). They found that although QFS patients show more of an inflammatory profile than CFS patients and HC, when comparing QFS patients to CFS patients, there is a striking resemblance and hardly any significant differences in microbiome taxonomy are found.
Netherlands epidemic[edit | edit source]
In 2005, Q fever was diagnosed on two dairy goat farms in the rural farm land in the southern area of the Netherlands. By 2010, more than 4,000 human cases were diagnosed, overwhelming the hospital, health care and veterinary care systems. Development of chronic Q fever (QFS) in infected patients remains an important problem in the Netherlands to this day.
Notable studies[edit | edit source]
- 2002, D. Raoult wrote an essay, "Q fever: still a mysterious disease" for QJM: An International Journal of Medicine and which he stated:
"It has been reported following Q fever in Australia and in the UK. In contrast, few cases of post‐Q‐fever fatigue have been documented from France and Canada. Wildman et al., in this issue of the journal, found that in the follow‐up of patients with Q fever, fatigue and idiopathic chronic fatigue were found in nearly 65% of patients, twice as frequently as in controls. Whether this fatigue is psychological in origin, or directly caused by the bacterium, is unknown."
- 2002, Marmion, B.P., et al., deconstructed Raoult's techniques and theory:
"The time is well past for sceptical opinion from the sidelines based on experience in unrelated Q fever research. We submit that it is now time for Dr Raoult's group to follow accepted scientific process and to attempt to confirm our results locally now that they have identified the fatigue syndrome (QFS=‘asthenia Q fever’) in French patients. It is necessary to follow patients systematically for more than two years after the initial acute infection." Marmion, et al., showed that more advanced assay methods identified approximately 8–10% of Q fever patients, who exhibit similar symptoms but do not reach immune or other homeostasis after one year or longer that constitute the serious social and medical problem known as Q fever fatigue syndrome.
- 2016, Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report.
- 2016, a literature review concluded that: "Long-term fatigue following acute Q-fever, generally referred to as QFS, has major health-related consequences. However, information on aetiology, prevention, treatment, and prognosis of QFS is underrepresented in the international literature."
- 2020, Multi-omics examination of Q Fever Fatigue Syndrome identifies similarities with Chronic Fatigue Syndrome
Research papers[edit | edit source]
- 2016, The natural history of acute Q fever: A prospective Australian cohort
- 2017, Q Fever: Confusion Between Chronic Infection and Chronic Fatigue
- 2018, Challenging queries of Q fever: emphasizing Q fever fatigue syndrome - (Full Text)
- 2019, Cytokine profiles in patients with Q fever fatigue syndrome - (Abstract)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- "Q Fever: Causes, Symptoms & Diagnosis". Healthline. August 7, 2012. Retrieved July 24, 2020.
- "Q Fever | Q Fever | CDC". Centers for Disease Control. September 16, 2019. Retrieved July 24, 2020.
- CDC (December 26, 2017). "Signs and Symptoms | Q Fever | CDC". Centers for Disease Control. Retrieved January 12, 2019.
- Keijmel, Stephan P.; Saxe, Johanna; van der Meer, Jos W. M.; Nikolaus, Stephanie; Netea, Mihai G.; Bleijenberg, Gijs; Bleeker-Rovers, Chantal P.; Knoop, Hans (October 2015). "A comparison of patients with Q fever fatigue syndrome and patients with chronic fatigue syndrome with a focus on inflammatory markers and possible fatigue perpetuating cognitions and behaviour". Journal of Psychosomatic Research. 79 (4): 295–302. doi:10.1016/j.jpsychores.2015.07.005. ISSN 1879-1360. PMID 26272528.
- Hickie, Ian; Davenport, Tracey; Wakefield, Denis; Vollmer-Conna, Ute; Cameron, Barbara; Vernon, Suzanne D.; Reeves, William C.; Lloyd, Andrew; Dubbo Infection Outcomes Study Group (September 16, 2006). "Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study". BMJ (Clinical research ed.). 333 (7568): 575. doi:10.1136/bmj.38933.585764.AE. ISSN 1756-1833. PMC 1569956. PMID 16950834.
- Raijmakers, Ruud; Roerink, Megan E.; Jansen, Anne F.M.; Keijmel, Stephan P.; Gacesa, Ranko; Li, Yang; Joosten, Leo A.B.; Meer, Jos W.M. van der; Netea, Mihai G. (August 19, 2020). "Multi-omics Examination of Q Fever Fatigue Syndrome Identifies Similarities with Chronic Fatigue Syndrome". Journal of Translational Medicine. doi:10.21203/rs.3.rs-54097/v1.
- Ledina, Dragan. "Chronic Fatigue Syndrome after Q fever". Invest in ME. Retrieved January 12, 2019.
- van der Hoek, Wim; Morroy, Gabriëlla; Renders, Nicole H. M.; Wever, Peter C.; Hermans, Mirjam H. A.; Leenders, Alexander C. A. P.; Schneeberger, Peter M. (2012). "Epidemic Q fever in humans in the Netherlands". Advances in Experimental Medicine and Biology. 984: 329–364. doi:10.1007/978-94-007-4315-1_17. ISSN 0065-2598. PMID 22711640.
- Dijkstra, Frederika; van der Hoek, Wim; Wijers, Nancy; Schimmer, Barbara; Rietveld, Ariene; Wijkmans, Clementine J.; Vellema, Piet; Schneeberger, Peter M. (February 2012). "The 2007–2010 Q fever epidemic in The Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming". FEMS immunology and medical microbiology. 64 (1): 3–12. doi:10.1111/j.1574-695X.2011.00876.x. ISSN 1574-695X. PMID 22066649.
- Raoult, D. (August 1, 2002). "Q fever: still a mysterious disease". QJM. 95 (8): 491–492. doi:10.1093/qjmed/95.8.491.
- Marmion, B.P. (December 1, 2002). "Q fever: still a mysterious disease". QJM. 95 (12): 832–833. doi:10.1093/qjmed/95.12.832.
- Sukocheva, Olga A.; Manavis, Jim; Kok, Tuck-Weng; Turra, Mark; Izzo, Angelo; Blumbergs, Peter; Marmion, Barrie P. (April 18, 2016). "Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report". BMC Infectious Diseases. 16 (1): 165. doi:10.1186/s12879-016-1497-z. ISSN 1471-2334. PMC 4835832. PMID 27091026.
- Morroy, Gabriella; Keijmel, Stephan P.; Delsing, Corine E.; Bleijenberg, Gijs; Langendam, Miranda; Timen, Aura; Bleeker-Rovers, Chantal P. (May 25, 2016). Samuel, James E (ed.). "Fatigue following Acute Q-Fever: A Systematic Literature Review". PLOS ONE. 11 (5): e0155884. doi:10.1371/journal.pone.0155884. ISSN 1932-6203. PMC 4880326. PMID 27223465.
- Hopper, B.; Cameron, B.; Li, H.; Graves, S.; Stenos, J.; Hickie, I.; Wakefield, D.; Vollmer-Conna, U.; Lloyd, A. R. (October 1, 2016). "The natural history of acute Q fever: a prospective Australian cohort". QJM: An International Journal of Medicine. 109 (10): 661–668. doi:10.1093/qjmed/hcw041. ISSN 1460-2725.
- Raoult, Didier (September 15, 2017). "Q Fever: Confusion Between Chronic Infection and Chronic Fatigue". Clinical Infectious Diseases. 65 (6): 1054–1055. doi:10.1093/cid/cix469. ISSN 1058-4838.
- Keijmel, S.P. (2018). "Challenging queries of Q fever, emphasizing Q fever fatigue syndrome". Radboud University Dissertation.
- Raijmakers, Ruud P.H.; Koeken, Valerie A.C.M.; Jansen, Anne F.M.; Keijmel, Stephan P.; Roerink, Megan E.; Joosten, Leo A.B.; Netea, Mihai G.; van der Meer, Jos W.M.; Bleeker-Rovers, Chantal P. (January 2019). "Cytokine profiles in patients with Q fever fatigue syndrome". Journal of Infection. doi:10.1016/j.jinf.2019.01.006.
assay 1. (verb) analysis (as of an ore or drug) to determine the presence, absence, or quantity of one or more components. 2. (noun) In biochemistry, any laboratory protocol used to test a sample for one or more qualities.
somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience. Although "Somatic Symptom Disorder" is the term used by DSM-5, the term "Bodily Distress Disorder" has been proposed for ICD-11. (Learn more: www.psychologytoday.com)
BMJ The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.