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[[File:Alan Light.png|upright|right|Source: University of Utah Faculty page]]
[[File:Alan Light.png|right|Source: University of Utah Faculty page]]
'''Alan R. Light''', Phd., is a Research Professor of Anesthesiology, Neurobiology and Anatomy at the Interdepartmental Program in Neuroscience at the University of Utah. He studies the neurobiology of pain and fatigue enhancement caused by injury and in [[Chronic Fatigue Syndrome]] and [[Fibromyalgia]].<ref>http://neuroscience.med.utah.edu/Faculty/Light.html</ref> Professor Light and his wife. Dr. [[Kathleen Light]], are known for their work on post-exertional gene expression after [[exercise]].
'''Alan R. Light''', Phd., is a Research Professor of Anesthesiology, Neurobiology and Anatomy at the Interdepartmental Program in Neuroscience at the University of Utah. He studies the neurobiology of pain and fatigue enhancement caused by injury and in [[Chronic Fatigue Syndrome]] and [[Fibromyalgia]].<ref>http://neuroscience.med.utah.edu/Faculty/Light.html</ref> Professor Light and his wife. Dr. [[Kathleen Light]], are known for their work on post-exertional gene expression after [[exercise]].


Dr. Light is a member of the Working Group which offers their expertise and resources to the [[ME/CFS Collaborative Research Center at Stanford University]].<ref>https://bos.etapestry.com/prod/viewEmailAsPage.do?erRef=773.0.423082047&databaseId=OMF&mailingId=34274682&jobRef=773.0.506425459&key=b6b9237b3ebd1e462a5d11dbc5c4dae&personaRef=773.0.423082048&memberId=1348639685</ref>  
Dr. Light is a member of the Working Group which offers their expertise and resources to the [[ME/CFS Collaborative Research Center at Stanford University]].<ref>{{Cite web|url=https://bos.etapestry.com/prod/viewEmailAsPage.do?erRef=773.0.423082047&databaseId=OMF&mailingId=34274682&jobRef=773.0.506425459&key=b6b9237b3ebd1e462a5d11dbc5c4dae&personaRef=773.0.423082048&memberId=1348639685|title=OMF grants $1.2M to Ramp Up Collaborative Research Center at Stanford University|website=bos.etapestry.com|access-date=2021-10-24}}</ref>  


==International Consensus Criteria==
==International Consensus Criteria==
Dr. Light is one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>  
Dr. Light is one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref>
 
 
==Awards==
==Awards==
*Javits Neuroscience Investigator Award (a seven-year research grant) from the [[NIH]] for his research on descending control of pain.<ref>https://faculty.utah.edu/u0320393-ALAN_R_LIGHT/research/index.hml</ref>
*Javits Neuroscience Investigator Award (a seven-year research grant) from the [[NIH]] for his research on descending control of pain.<ref>{{Cite web|url=https://faculty.utah.edu/u0320393-ALAN_R_LIGHT/research/index.hml|title=ALAN R LIGHT - Research - Faculty Profile - The University of Utah|website=faculty.utah.edu|access-date=2021-10-24}}</ref>
*2010 - Won Second Place in Oral Presentations at the 2010 Annual Meeting of the American Society Anesthesiologists for ''A novel approach to studying the sensory pathways involved in the perception of fatigue''<ref>https://www.jccjournal.org/article/S0883-9441(10)00264-9/abstract</ref>
*2010 - Won Second Place in Oral Presentations at the 2010 Annual Meeting of the American Society Anesthesiologists for ''A novel approach to studying the sensory pathways involved in the perception of fatigue''<ref>{{Cite journal|last=Pollak|first=Kelly|last2=Jo|first2=Daehyun|last3=Vanhaitsma|first3=Timothy|last4=Hughen|first4=Ron|last5=Light|first5=Alan|date=2010-12-01|title=A novel approach to studying the sensory pathways involved in the perception of fatigue|url=https://www.sciencedirect.com/science/article/pii/S0883944110002649|journal=Journal of Critical Care|language=en|volume=25|issue=4|pages=e18|doi=10.1016/j.jcrc.2010.08.023|issn=0883-9441}}</ref>


==Education==
==Education==
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*2009, Moderate [[Exercise]] Increases Expression for Sensory, Adrenergic, and Immune Genes in [[Chronic Fatigue Syndrome]] Patients But Not in Normal Subjects<ref>Light, A.R., White, A.T., Hughen, R.W., and Light, K.C. (2009) Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects. ''The Journal of Pain'', 10:1099-1112.</ref> [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757484/ (Full Text)]
*2009, Moderate [[Exercise]] Increases Expression for Sensory, Adrenergic, and Immune Genes in [[Chronic Fatigue Syndrome]] Patients But Not in Normal Subjects<ref>Light, A.R., White, A.T., Hughen, R.W., and Light, K.C. (2009) Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects. ''The Journal of Pain'', 10:1099-1112.</ref> [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757484/ (Full Text)]
*2010, Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome<ref>White, A.T., Light, A.R., Hughen, R.W., Bateman, L., Martins, T.B., Hill, H.R., and Light, K.C. (2010) Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. ''Psychophysiology'', 47(4):615-24. doi: 10.1111./j.1469-8986.2010.00978.x</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378647/ (Full Text)]
*2010, Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome<ref>White, A.T., Light, A.R., Hughen, R.W., Bateman, L., Martins, T.B., Hill, H.R., and Light, K.C. (2010) Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. ''Psychophysiology'', 47(4):615-24. doi: 10.1111./j.1469-8986.2010.00978.x</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378647/ (Full Text)]
*2010, A novel approach to studying the sensory pathways involved in the perception of fatigue<ref name="Pollak, 2010"/> [https://www.jccjournal.org/article/S0883-9441(10)00264-9/abstract (Abstract)]
*2010, A novel approach to studying the sensory pathways involved in the perception of fatigue<ref name="Pollak, 2010" /> [https://www.jccjournal.org/article/S0883-9441(10)00264-9/abstract (Abstract)]
*2011, Absence of [[XMRV]] retrovirus and other murine leukemia virus-related viruses in patients with [[chronic fatigue syndrome]]<ref>{{Cite journal|last=Shin|first=Clifford H.|last2=Bateman|first2=Lucinda|author-link2=Lucinda Bateman|last3=Schlaberg|first3=Robert|last4=Bunker|first4=Ashley M.|last5=Leonard|first5=Christopher J.|last6=Hughen|first6=Ronald W.|last7=Light|first7=Alan R.|author-link7=Alan Light|last8=Light|first8=Kathleen C|author-link8=Kathleen Light|last9=Singh|first9=Ila R.|date=Jul 2011|title=Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126563/|journal=Journal of Virology|volume=85|issue=14|pages=7195-202|doi=10.1128/JVI.00693-11|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126563/ (Full Text)]
*2011, Absence of [[XMRV]] retrovirus and other murine leukemia virus-related viruses in patients with [[chronic fatigue syndrome]]<ref>{{Cite journal|last=Shin|first=Clifford H.|last2=Bateman|first2=Lucinda|author-link2=Lucinda Bateman|last3=Schlaberg|first3=Robert|last4=Bunker|first4=Ashley M.|last5=Leonard|first5=Christopher J.|last6=Hughen|first6=Ronald W.|last7=Light|first7=Alan R.|author-link7=Alan Light|last8=Light|first8=Kathleen C|author-link8=Kathleen Light|last9=Singh|first9=Ila R.|date=Jul 2011|title=Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126563/|journal=Journal of Virology|volume=85|issue=14|pages=7195-202|doi=10.1128/JVI.00693-11|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126563/ (Full Text)]
*2011, Evidence for a heritable predisposition to [[Chronic Fatigue Syndrome]]<ref name="Albright, 2011"/> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128000/ (Full Text)]  
*2011, Evidence for a heritable predisposition to [[Chronic Fatigue Syndrome]]<ref name="Albright, 2011" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128000/ (Full Text)]  
*2011, [[Myalgic encephalomyelitis]]: [[International Consensus Criteria]]<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427890/ (Full Text)]
*2011, [[Myalgic encephalomyelitis]]: [[International Consensus Criteria]]<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427890/ (Full Text)]
*2012, Gene expression alterations at baseline and following moderate [[exercise]] in patients with [[Chronic Fatigue Syndrome]] and [[Fibromyalgia]] Syndrome<ref name="Light, 2012"/> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175315/ (Full Text)]
*2012, Gene expression alterations at baseline and following moderate [[exercise]] in patients with [[Chronic Fatigue Syndrome]] and [[Fibromyalgia]] Syndrome<ref name="Light, 2012" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175315/ (Full Text)]
*2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate [[exercise]] in patients with [[chronic fatigue syndrome]], patients with [[multiple sclerosis]], and healthy controls<ref name="White, 2012"/> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256093/ (Full text)]
*2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate [[exercise]] in patients with [[chronic fatigue syndrome]], patients with [[multiple sclerosis]], and healthy controls<ref name="White, 2012" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256093/ (Full text)]
*2012, Genetics and Gene Expression Involving Stress and Distress Pathways in [[Fibromyalgia]] with and without Comorbid [[Chronic Fatigue Syndrome]]<ref>Light KC, White AT, Tadler S, Iacob E, Light AR. Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. ''Pain Research and Treatment''. 2012:427869. doi: 10.1155/2012/427869</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200121/ (Full text)]
*2012, Genetics and Gene Expression Involving Stress and Distress Pathways in [[Fibromyalgia]] with and without Comorbid [[Chronic Fatigue Syndrome]]<ref>Light KC, White AT, Tadler S, Iacob E, Light AR. Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. ''Pain Research and Treatment''. 2012:427869. doi: 10.1155/2012/427869</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200121/ (Full text)]
*2013, Differing [[leukocyte]] gene expression profiles associated with fatigue in patients with prostate cancer versus [[chronic fatigue syndrome]]<ref>Light, K.C., Agarwal, N., Iacob, E., White, A.T., Kinney, A.Y., Vanhaitsma, T.A., Aizad, H., Hughen, R.W., Bateman, L., and Light, A.R. (2013) Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. ''Psychoneuroendocrinology'', Sep 6. doi:pii: S0306-4530(13)00297-7. 10.1016/j.psyneuen.2013.08.008</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848711/ (Full Text)]
*2013, Differing [[leukocyte]] gene expression profiles associated with fatigue in patients with prostate cancer versus [[chronic fatigue syndrome]]<ref>Light, K.C., Agarwal, N., Iacob, E., White, A.T., Kinney, A.Y., Vanhaitsma, T.A., Aizad, H., Hughen, R.W., Bateman, L., and Light, A.R. (2013) Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. ''Psychoneuroendocrinology'', Sep 6. doi:pii: S0306-4530(13)00297-7. 10.1016/j.psyneuen.2013.08.008</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848711/ (Full Text)]
*2013, [[post-exertional malaise|Post-Exertion Malaise]] in [[Chronic Fatigue Syndrome]]: Symptoms and Gene Expression<ref name="Meyer, 2013"/> [http://www.tandfonline.com/doi/full/10.1080/21641846.2013.838444 (Abstract)]
*2013, [[post-exertional malaise|Post-Exertion Malaise]] in [[Chronic Fatigue Syndrome]]: Symptoms and Gene Expression<ref name="Meyer, 2013" /> [http://www.tandfonline.com/doi/full/10.1080/21641846.2013.838444 (Abstract)]
*2016, Gene expression factor analysis to differentiate pathways linked to [[fibromyalgia]], [[chronic fatigue syndrome]], and [[depression]] in a diverse patient sample<ref name="Iacob, 2016"/> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684820/ (Full Text)]  
*2016, Gene expression factor analysis to differentiate pathways linked to [[fibromyalgia]], [[chronic fatigue syndrome]], and [[depression]] in a diverse patient sample<ref name="Iacob, 2016" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684820/ (Full Text)]  
*2017, Symptom variability following acute [[exercise]] in [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]]: a perspective on measuring [[post-exertional malaise|post-exertion malaise]]<ref name="Lindheimer, 2017"/> [https://doi.org/10.1080/21641846.2017.1321166 (Abstract)]
*2017, Symptom variability following acute [[exercise]] in [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]]: a perspective on measuring [[post-exertional malaise|post-exertion malaise]]<ref name="Lindheimer, 2017" /> [https://doi.org/10.1080/21641846.2017.1321166 (Abstract)]
*2017, Neural Consequences of [[post-exertional malaise|Post-Exertion Malaise]] in [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]]<ref name="Cook, 2017"/> [http://www.sciencedirect.com/science/article/pii/S088915911730051X (Full Text)]
*2017, Neural Consequences of [[post-exertional malaise|Post-Exertion Malaise]] in [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]]<ref name="Cook, 2017" /> [http://www.sciencedirect.com/science/article/pii/S088915911730051X (Full Text)]


==Open Letter to ''The Lancet''==  
==Open Letter to ''The Lancet''==  
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==See also==
==See also==
*[[Exercise]]
*[[Exercise]]
*[[Two-day cardiopulmonary exercise testing]]
*[[Two-day cardiopulmonary exercise test]]


==References==
==References==
<references>
<references>
<ref name="Albright, 2011">
<ref name="Albright, 2011">{{Citation
{{Citation
| last1  = Albright        | first1 = Frederick    | authorlink1 =  
| last1  = Albright        | first1 = Frederick    | authorlink1 =  
| last2  = Light          | first2 = Kathleen    | authorlink2 = Kathleen Light  
| last2  = Light          | first2 = Kathleen    | authorlink2 = Kathleen Light  
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}}
}}
</ref>
</ref>
<ref name="Cook, 2017">
<ref name="Cook, 2017">{{Citation
{{Citation
| last1  = Cook        | first1 = Dane B.        | authorlink1 = Dane Cook
| last1  = Cook        | first1 = Dane B.        | authorlink1 = Dane Cook
| last2  = Light        | first2 = Alan R.        | authorlink2 = Alan Light
| last2  = Light        | first2 = Alan R.        | authorlink2 = Alan Light
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}}
}}
</ref>
</ref>
<ref name="Iacob, 2016">
<ref name="Iacob, 2016">{{Citation
{{Citation
| last1  = Iacob        | first1 = E        | authorlink1 =  
| last1  = Iacob        | first1 = E        | authorlink1 =  
| last2  = Light        | first2 = AR        | authorlink2 = Alan Light  
| last2  = Light        | first2 = AR        | authorlink2 = Alan Light  
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| doi    = 10.1002/acr.22639
| doi    = 10.1002/acr.22639
}}
}}
</ref>  
</ref>
<ref name="Light, 2012">
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Revision as of 13:24, October 24, 2021

Source: University of Utah Faculty page

Alan R. Light, Phd., is a Research Professor of Anesthesiology, Neurobiology and Anatomy at the Interdepartmental Program in Neuroscience at the University of Utah. He studies the neurobiology of pain and fatigue enhancement caused by injury and in Chronic Fatigue Syndrome and Fibromyalgia.[1] Professor Light and his wife. Dr. Kathleen Light, are known for their work on post-exertional gene expression after exercise.

Dr. Light is a member of the Working Group which offers their expertise and resources to the ME/CFS Collaborative Research Center at Stanford University.[2]

International Consensus Criteria[edit | edit source]

Dr. Light is one of the authors of the 2011 case definition, International Consensus Criteria.[3]

Awards[edit | edit source]

  • Javits Neuroscience Investigator Award (a seven-year research grant) from the NIH for his research on descending control of pain.[4]
  • 2010 - Won Second Place in Oral Presentations at the 2010 Annual Meeting of the American Society Anesthesiologists for A novel approach to studying the sensory pathways involved in the perception of fatigue[5]

Education[edit | edit source]

  • B.A. 1972, Hamilton College
  • Ph.D. 1977, SUNY at Upstate Medical Center
  • Postdoctoral Fellow 1977-1979, UNC-Chapel Hill

Talks and interviews[edit | edit source]

Short web seminars Science to patients / Wetenschap voor patienten

English spoken, dutch subtitles

Books[edit | edit source]

  • 2010, Chapter 11: Myalgia and Fatigue—Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes In: Translational Pain Research – From Mouse to Man[6] (Full Text)

Publications related to ME/CFS[edit | edit source]

Open Letter to The Lancet[edit | edit source]

Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Light, along with 41 colleagues in the ME/CFS field, signed the second letter.

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ http://neuroscience.med.utah.edu/Faculty/Light.html
  2. ↑ "OMF grants $1.2M to Ramp Up Collaborative Research Center at Stanford University". bos.etapestry.com. Retrieved October 24, 2021.
  3. ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
  4. ↑ "ALAN R LIGHT - Research - Faculty Profile - The University of Utah". faculty.utah.edu. Retrieved October 24, 2021.
  5. ↑ Pollak, Kelly; Jo, Daehyun; Vanhaitsma, Timothy; Hughen, Ron; Light, Alan (December 1, 2010). "A novel approach to studying the sensory pathways involved in the perception of fatigue". Journal of Critical Care. 25 (4): e18. doi:10.1016/j.jcrc.2010.08.023. ISSN 0883-9441.
  6. ↑ Light, A.R. Vierck, C.J., and Light, K.C. (2010) Chapter 11: Myalgia and Fatigue—Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes In: Translational Pain Research – From Mouse to Man, Lawrence Kruger and Alan Light, editors; Taylor and Francis.
  7. ↑ Light, A.R., White, A.T., Hughen, R.W., and Light, K.C. (2009) Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects. The Journal of Pain, 10:1099-1112.
  8. ↑ White, A.T., Light, A.R., Hughen, R.W., Bateman, L., Martins, T.B., Hill, H.R., and Light, K.C. (2010) Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. Psychophysiology, 47(4):615-24. doi: 10.1111./j.1469-8986.2010.00978.x
  9. ↑ Pollak, Kelly; Jo, Daehyun; Vanhaitsma, Timothy A; Hughen, Ron W; Light, Alan R (2010), "A novel approach to studying the sensory pathways involved in the perception of fatigue.", Journal of Critical Care, 25 (4): e18, doi:10.1016/j.jcrc.2010.08.023
  10. ↑ Shin, Clifford H.; Bateman, Lucinda; Schlaberg, Robert; Bunker, Ashley M.; Leonard, Christopher J.; Hughen, Ronald W.; Light, Alan R.; Light, Kathleen C; Singh, Ila R. (July 2011). "Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome". Journal of Virology. 85 (14): 7195–202. doi:10.1128/JVI.00693-11.
  11. ↑ Albright, Frederick; Light, Kathleen; Light, Alan; Bateman, Lucinda; Cannon-Albright, Lisa A (2011), "Evidence for a heritable predisposition to Chronic Fatigue Syndrome", BMC Neurology, 11 (62), doi:10.1186/1471-2377-11-62
  12. ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
  13. ↑ Light, Alan R; Bateman, Lucinda; Jo, Daehyun; Hughen, RW; Vanhaitsma, TA; White, AT; Light, Kathleen (2012), "Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome", Journal of Internal Medicine, 271 (1): 64-81, doi:10.1111/j.1365-2796.2011.02405.x
  14. ↑ White, AT; Light, AR; Hughen, RW; Vanhaitsma, TA; Light, KC (2012), "Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls", Psychosomatic Medicine, 74 (1): 46-54, doi:10.1097/PSY.0b013e31824152ed
  15. ↑ Light KC, White AT, Tadler S, Iacob E, Light AR. Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. Pain Research and Treatment. 2012:427869. doi: 10.1155/2012/427869
  16. ↑ Light, K.C., Agarwal, N., Iacob, E., White, A.T., Kinney, A.Y., Vanhaitsma, T.A., Aizad, H., Hughen, R.W., Bateman, L., and Light, A.R. (2013) Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. Psychoneuroendocrinology, Sep 6. doi:pii: S0306-4530(13)00297-7. 10.1016/j.psyneuen.2013.08.008
  17. ↑ Meyer, Jacob D; Light, Alan R; Shukla, Sanjay K; Clevidence, Derek; Yale, Steven; Stegner, Aaron J; Cook, Dane C (2013), "Post-Exertion Malaise in Chronic Fatigue Syndrome: Symptoms and Gene Expression", Fatigue: Biomedicine, Health, & Behavior, 1 (4): 190-209, doi:10.1080/21641846.2013.838444
  18. ↑ Iacob, E; Light, AR; Donaldson, GW; Okifuji, A; Hughen, RW; White, AT; Light, K (2016), "Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample", Arthritis Care and Research, 68 (1): 132-40, doi:10.1002/acr.22639, PMID 26097208
  19. ↑ Lindheimer, Jacob B.; Meyer, Jacob D.; Stegner, Aaron J.; Dougherty, Ryan J.; Van Riper, Stephanie M.; Shields, Morgan; Reisner, Amanda; Shukla, Sanjay K.; Light, Alan R.; Yale, Steven; Cook, Dane B. (2017), "Symptom variability following acute exercise in myalgic encephalomyelitis/chronic fatigue syndrome: a perspective on measuring post-exertion malaise", Fatigue: Biomedicine, Health & Behavior, 5 (2): 69-88, doi:10.1080/21641846.2017.1321166
  20. ↑ Cook, Dane B.; Light, Alan R.; Light, Kathleen C.; Broderick, Gordon; Shields, Morgan R.; Dougherty, Ryan J.; Meyer, Jacob D.; VanRiper, Stephanie; Stegner, Aaron J.; Ellingson, Laura D.; Vernon, Suzanne D. (2017), "Neural Consequences of Post-Exertion Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Brain, Behavior, and Immunity, doi:10.1016/j.bbi.2017.02.009

myalgia Muscle pain

chronic fatigue (CF) - Persistent and abnormal fatigue is a symptom, not an illness. It may be caused by depression, multiple sclerosis, fibromyalgia, chronic fatigue syndrome or many other illnesses. The term "chronic fatigue" should never be confused with the disease chronic fatigue syndrome.

flare-up A symptoms flare in ME/CFS is a temporary increase in symptoms, alternatively known as experiencing post-exertional malaise. May be referred to as a "crash" or "collapse".

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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