Neuroendocrine system

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The neuroendocrine system.[1][2]

Function[edit | edit source]

Metabolism[edit | edit source]

[3]

Immune system, stress and neuroendocrinology[edit | edit source]

[4]

Sleep[edit | edit source]

[5]

Stress and the HPA axis[edit | edit source]

Stress can refer to emotional (psychological) stress]] or physical stress, e.g. a tension or pulling on a part of the body.[6]

[7]

Hypothalamic-pituitary-gonadal Axis[edit | edit source]

ME/CFS[edit | edit source]

Differential diagnoses[edit | edit source]

The following endocrine disorders are differential diagnosis that may need to be investigated before a diagnosis of ME is made:

Symptom recognition[edit | edit source]

The International Consensus Criteria for myalgic encephalomyelitis recognizes loss of thermostatic stability and intolerance of extremes of temperature as neuroendocrine symptoms involving the autonomic nervous system (ANS).[8]

Treatment[edit | edit source]

The clinicians' primer for the International Consensus Criteria for ME suggests that galangtamine and melatonin may improve HPA axis symptoms, and vitamin C has a role in maintaining healthy adrenal glands.[8]

Notable studies[edit | edit source]

  • 1995, Contrasting neuroendocrine responses in depression and chronic fatigue syndrome[9]
  • 2003, The neuroendocrinology of chronic fatigue syndrome[10]
  • 2004, Neuroendocrine Aspects of Chronic Fatigue Syndrome[11]
  • 2006, Combinations of single nucleotide polymorphisms in neuroendocrine effector receptor genes predict chronic fatigue syndrome[12]
  • 2007, Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions[13]
  • 2008, Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis[14]
  • 2014, Main neuroendocrine features, diagnosis and therapeutic possibilities in the chronic fatigue syndrome, an underdiagnosed entity[15]
  • 2021, The immune-neuroendocrine system in COVID-19, advanced age and rheumatic diseases[16](Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Plant, Tony M. (August 2015). "60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary-gonadal axis". The Journal of Endocrinology. 226 (2): T41–54. doi:10.1530/JOE-15-0113. ISSN 1479-6805. PMC 4498991. PMID 25901041.
  2. Farzi, Aitak; Fröhlich, Esther E.; Holzer, Peter (January 2018). "Gut Microbiota and the Neuroendocrine System". Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics. 15 (1): 5–22. doi:10.1007/s13311-017-0600-5. ISSN 1878-7479. PMC 5794709. PMID 29380303.
  3. Park, Hyeong-Kyu; Ahima, Rexford S. (January 2015). "Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism". Metabolism: Clinical and Experimental. 64 (1): 24–34. doi:10.1016/j.metabol.2014.08.004. ISSN 1532-8600. PMC 4267898. PMID 25199978.
  4. Ménard, Caroline; Pfau, Madeline L.; Hodes, Georgia E.; Russo, Scott J. (January 2017). "Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience". Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 42 (1): 62–80. doi:10.1038/npp.2016.90. ISSN 1740-634X. PMC 5143517. PMID 27291462.
  5. Smith, Philip C.; Mong, Jessica A. (2019). "Neuroendocrine Control of Sleep". Current Topics in Behavioral Neurosciences. 43: 353–378. doi:10.1007/7854_2019_107. ISSN 1866-3370. PMC 6986346. PMID 31396895.
  6. Stevenson, Angus; Lindberg, Christine A., eds. (2015). New Oxford American Dictionary. Oxford University Press.
  7. Smith, Sean M.; Vale, Wylie W. (2006). "The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress". Dialogues in Clinical Neuroscience. 8 (4): 383–395. ISSN 1294-8322. PMC 3181830. PMID 17290797.
  8. 8.08.18.2 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
  9. Cleare, A. J.; Bearn, J.; Allain, T.; McGregor, A.; Wessely, S.; Murray, R. M.; O'Keane, V. (August 18, 1995). "Contrasting neuroendocrine responses in depression and chronic fatigue syndrome". Journal of Affective Disorders. 34 (4): 283–289. doi:10.1016/0165-0327(95)00026-j. ISSN 0165-0327. PMID 8550954.
  10. Cleare, Anthony J. (April 2003). "The neuroendocrinology of chronic fatigue syndrome". Endocrine Reviews. 24 (2): 236–252. doi:10.1210/er.2002-0014. ISSN 0163-769X. PMID 12700181.
  11. Papanicolaou, Dimitris A.; Amsterdam, Jay D.; Levine, Susan; McCann, Samuel M.; Moore, Rebecca C.; Newbrand, Clare H.; Allen, Glen; Nisenbaum, Rosane; Pfaff, Donald W. (2004). "Neuroendocrine Aspects of Chronic Fatigue Syndrome". Neuroimmunomodulation. 11 (2): 65–74. doi:10.1159/000075315. ISSN 1021-7401. PMID 14758052.
  12. Goertzel, Benjamin N.; Pennachin, Cassio; de Souza Coelho, Lucio; Gurbaxani, Brian; Maloney, Elizabeth M.; Jones, James F. (April 2006). "Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome". Pharmacogenomics. 7 (3): 475–483. doi:10.2217/14622416.7.3.475. ISSN 1462-2416. PMID 16610957.
  13. Klimas, Nancy G.; O'Brien Koneru, Anne (December 2007). "Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions". Current Rheumatology Reports. 9 (6): 482–487. doi:10.1007/s11926-007-0078-y. ISSN 1523-3774. PMID 18177602.
  14. Fuite, Jim; Vernon, Suzanne D.; Broderick, Gordon (December 2008). "Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis". Genomics. 92 (6): 393–399. doi:10.1016/j.ygeno.2008.08.008. ISSN 1089-8646. PMID 18775774.
  15. Amihăesei, Ioana Cristina; Cojocaru, Elena (July 2014). "Main neuroendocrine features, diagnosis and therapeutic possibilities in the chronic fatigue syndrome, an underdiagnosed entity". Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi. 118 (3): 688–691. ISSN 0048-7848. PMID 25341286.
  16. Jara, Luis J.; López-Zamora, Berenice; Ordoñez-González, Irvin; Galaviz-Sánchez, María F.; Gutierrez-Melgarejo, Caroline I.; Saavedra, Miguel Ángel; Vera-Lastra, Olga; Cruz-Domínguez, María Pilar; Medina, Gabriela (November 2021). "The immune-neuroendocrine system in COVID-19, advanced age and rheumatic diseases". Autoimmunity Reviews. 20 (11): 102946. doi:10.1016/j.autrev.2021.102946. ISSN 1568-9972. PMC 8428987. PMID 34509651.

neuroendocrine relating to hormones that influence the nervous system

single nucleotide polymorphism (SNP) - A single nucleotide polymorphism (SNP, pronounced "snip") is a potential genetic mutation that occurs in a single spot in the human genome; a difference in a single DNA building block. SNPs are often represented by an "rs" number, such as "rs53576".

Oxford University a prestigious university located in Oxford, England renowned for its teaching and research in health and medicine

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.