Sleep dysfunction

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Sleep dysfunction is nearly universal in ME/CFS patients, although it can take a very wide range of forms. These include dysania, hypersomnia, hypnagogia, insomnia, light sleep, myoclonus, nightmares, night sweats, phase shifting, somnolence, and unrefreshing sleep.

Prevalence[edit | edit source]

Depending on the criteria used for diagnosis, prevalence can vary greatly.

Symptom recognition[edit | edit source]

Sleep dysfunction is a core requirement to meet the diagnostic criteria for ME/CFS according to the 2003 Canadian Consensus Criteria,[1] the 2007 Nightingale definition,[2] and the 2015 Institute of Medicine report.[3]

Sleep dysfunction is an optional symptom in the 1988 Holmes criteria,[4] the 1991 Oxford criteria,[5] the 1994 Fukuda criteria,[6] the 2005 Reeves criteria,[7] the 2007 NICE guidelines,[8] the 2012 International Consensus Criteria[9], and the 2014 London criteria.[10]

Sleep dysfunction is not a criteria listed for diagnosis with the 1986 Ramsay definition.[11]

Notable studies[edit | edit source]

Treatment[edit | edit source]

Treatment can include sedatives, antidepressants, cannabidiol (CBD), meditation and good sleep hygiene practices.

Amitriptyline may be helpful for improving quality of sleep in individuals with CFS. [16][17] While originally considered an antidepressant, it is also prescribed at low doses to specifically manage pain and sleep for a number of conditions.

References[edit | edit source]

  1. http://www.tandfonline.com/doi/abs/10.1300/J092v11n01_02#.VmfS2GHXJhE
  2. http://www.nightingale.ca/documents/Nightingale_ME_Definition_en.pdf
  3. http://iom.nationalacademies.org/~/media/Files/Report%20Files/2015/MECFS/MECFS_ProposedDiagnosticCriteria?_ga=1.14761526.1865741811.1437002921
  4. https://www.ncbi.nlm.nih.gov/pubmed/2829679
  5. https://www.ncbi.nlm.nih.gov/pubmed/1999813
  6. https://www.ncbi.nlm.nih.gov/pubmed/7978722
  7. https://www.ncbi.nlm.nih.gov/pubmed/16356178
  8. https://www.nice.org.uk/guidance/CG53/chapter/1-Guidance#diagnosis
  9. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02428.x/full
  10. http://www.axfordsabode.org.uk/me/mecrit2014.htm
  11. The Clinical Features of Myalgic Encephalomyelitis
  12. Morris, Gerwyn; Stubbs, Brendon; Köhler, Cristiano A.; Walder, Ken; Slyepchenko, Anastasiya; Berk, Michael; Carvalho, André F. (2018), "The putative role of Oxidative Stress and Inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders : Focus on Chronic Fatigue Syndrome, Bipolar Disorder and Multiple Sclerosis", Sleep Med Reviews, doi:10.1016/j.smrv.2018.03.007, PMID 29759891 
  13. Josev EK, Jackson ML, Bei B, Trinder J, Harvey A, Clarke C, Snodgrass K, Scheinberg A, Knight SJ. (2017) Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). J Clin Sleep Med. 2017 Jul 28. pii: jc-17-00047
  14. Jackson, ML; Bruck, D (2012), "Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review, Journal of Clinical Sleep Medicine", Journal of Clinical Sleep Medicine, 8 (6): 719-28, doi:10.5664/jcsm.2276 
  15. Olivier Le Bon, Daniel Neu, Filomena Valente & Paul Linkowski. (2007). Health-Related Quality of Life in Chronic Fatigue Syndrome versus Rheumatoid Arthritis as Control Group. Journal of Chronic Fatigue Syndrome, Vol. 14, Iss. 2, pp. 45-59. DOI:10.1300/J092v14n02_05
  16. http://sacfs.asn.au/download/guidelines.pdf
  17. http://www.nhs.uk/Conditions/Chronic-fatigue-syndrome/Pages/Treatment.aspx


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history