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Photo of a label of L-serine supplements

L-serine is a non-essential amino acid which is a precursor to several other amino acids (including glycine and L-cysteine, and of some cell membrane lipids.[1][2] Ito et al. 2014 report that it has an extensive role in protein synthesis and intracellular metabolism.[2]

Potential uses[edit | edit source]

L-serine is of potential use for insomnia or sleeping problems.[2]

Theory[edit | edit source]

Evidence[edit | edit source]

Two small randomized double-blinded crossover studies (clinical trials) by Ito et al. (2014) found that a dose of 3g (3000mg) or L-serine improved sleep maintenance and reduced time until sleep compared to a placebo treatment.[2]

ME/CFS[edit | edit source]

A study by Huth et al. (2020) found increased levels of L-serine in the blood serum of ME/CFS patients compared to healthy controls, and decreased levels of serine in the urine of ME/CFS patients.[3]

Risks and side effects[edit | edit source]

Costs and availability[edit | edit source]

L-serine is inexpensive and available over the counter as a capsule or powder.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. de Koning, Tom J; Snell, Keith; Duran, Marinus; Berger, Ruud; Poll-The, Bwee-Tien; Surtees, Robert (May 1, 2003). "L-serine in disease and development". Biochemical Journal. 371 (Pt 3): 653–661. doi:10.1042/BJ20021785. ISSN 0264-6021. PMC 1223326. PMID 12534373.
  2. Ito, Yukihiko; Takahashi, Satomi; Shen, Manzhen; Yamaguchi, Kohji; Satoh, Makoto (August 22, 2014). "Effects of L-serine ingestion on human sleep". SpringerPlus. 3. doi:10.1186/2193-1801-3-456. ISSN 2193-1801. PMC 4155056. PMID 25197619.
  3. Huth, Teilah Kathryn; Eaton-Fitch, Natalie; Staines, Donald; Marshall-Gradisnik, Sonya (December 2020). "A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID)". Journal of Translational Medicine. 18 (1): 198. doi:10.1186/s12967-020-02356-2. ISSN 1479-5876. PMC 7222338. PMID 32404171.

cell membrane A very thin membrane, composed of lipids and protein, that surrounds the cytoplasm of a cell and controls the passage of substances into and out of the cell.

double blinded trial A clinical trial is double blinded if neither the participants nor the researchers know which treatment group they are allocated to until after the results are interpreted. This reduces bias. (Learn more:

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

adverse reaction Any unintended or unwanted response to a treatment, whether in a clinical trial or licensed treatment. May be minor or serious.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.