Fukuda criteria

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The Fukuda criteria (or CDC 1994 criteria) are a criteria for the diagnosis Chronic Fatigue Syndrome (CFS) published in 1994. It has been widely used in research.

Authors[edit]

Keiji Fukuda; Stephen Straus; Ian Hickie; Michael Sharpe; James Dobbins; Anthony Komaroff, International Chronic Fatigue Syndrome Study Group.

CDC Fukuda definition of CFS[edit]

Primary symptoms

Clinically evaluated, unexplained, persistent or relapsing chronic fatigue that is: of new or definite onset (has not been lifelong); is not the result of ongoing exertion; is not substantially alleviated by rest; and results in substantial reduction in previous levels of occupational, educational, social, or personal activities.


Additional symptoms

The concurrent occurrence of four or more of the following symptoms, all of which must have persisted or recurred during six or more consecutive months of illness and must not have predated the fatigue:

These symptoms must have persisted or recurred during 6 or more consecutive months of illness and must not have predated the fatigue.


Final requirement

All other known causes of chronic fatigue must have been ruled out, specifically clinical depression, side effects of medication, eating disorders and substance abuse.

Questionnaire[edit]

PDF By: IACFSME

Criteria, Exclusions and Severity.[1]

Criticisms[edit]

  • Post-exertional malaise (PEM) is not mandatory. (Most US researchers do use PEM option.)
  • Doctors and researchers not using PEM option have misdiagnosed Chronic Fatigue (CF) patients with Chronic Fatigue Syndrome (CFS).[2]
  • In research, if PEM option is not used the study is not considered by patients and many researchers to be a true CFS study; it is considered to be a (CF) study. Or both CFS and CF patients are in a CFS study as some patients have PEM and other patients do not making the study severely flawed and useless to either CFS or CF research.
  • It is not easy to use on a clinical level as it was created for research. It can take several specialists and years to diagnose a patient.
  • Dual diagnosis is not always possible and this is not useful in a clinical setting. (i.e., AIDS + CFS or MS + CFS.)
  • Leads to confusion over Chronic Fatigue (a symptom of many illness, depression, diseases, medications) and Chronic Fatigue Syndrome (a grossly misnamed disease.)[3]

Learn more[edit]

See also[edit]

References[edit]

  1. PDF Questionaire - IACFSME.org
  2. Chronic Fatigue is NOT Chronic Fatigue Syndrome - VOAT
  3. Chronic Fatigue Versus Chronic Fatigue Syndrome - About.com Health - By: Carol Eustice


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history