Fukuda criteria

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The Fukuda criteria (or CDC 1994 criteria) are a criteria for the diagnosis Chronic Fatigue Syndrome (CFS) published in 1994. It has been widely used in research.


Keiji Fukuda; Stephen Straus; Ian Hickie; Michael Sharpe; James Dobbins; Anthony Komaroff, International Chronic Fatigue Syndrome Study Group.


The concurrent occurrence of four or more of the following symptoms:

These symptoms must have persisted or recurred during 6 or more consecutive months of illness and must not have predated the fatigue.



Criteria, Exclusions and Severity.[1]


  • Post-exertional malaise (PEM) is not mandatory. (Most US researchers do use PEM option.)
  • Doctors and researchers not using PEM option have misdiagnosed Chronic Fatigue (CF) patients with Chronic Fatigue Syndrome (CFS).[2]
  • In research, if PEM option is not used the study is not considered by patients and many researchers to be a true CFS study; it is considered to be a (CF) study. Or both CFS and CF patients are in a CFS study as some patients have PEM and other patients do not making the study severely flawed and useless to either CFS or CF research.
  • It is not easy to use on a clinical level as it was created for research. It can take several specialists and years to diagnose a patient.
  • Dual diagnosis is not always possible and this is not useful in a clinical setting. (i.e., AIDS + CFS or MS + CFS.)
  • Leads to confusion over Chronic Fatigue (a symptom of many illness, depression, diseases, medications) and Chronic Fatigue Syndrome (a grossly misnamed disease.)[3]

Learn more[edit]

See also[edit]


  1. PDF Questionaire - IACFSME.org
  2. Chronic Fatigue is NOT Chronic Fatigue Syndrome - VOAT
  3. Chronic Fatigue Versus Chronic Fatigue Syndrome - About.com Health - By: Carol Eustice

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history