Alan Light

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Source: University of Utah Faculty page

Alan R. Light, Phd., is a Research Professor of Anesthesiology, Neurobiology and Anatomy at the Interdepartmental Program in Neuroscience at the University of Utah. He studies the neurobiology of pain and fatigue enhancement caused by injury and in Chronic Fatigue Syndrome and Fibromyalgia.[1] Professor Light and his wife. Dr. Kathleen Light, are known for their work on post-exertional gene expression after exercise.

Dr. Light is a member of the Working Group which offers their expertise and resources to the ME/CFS Collaborative Research Center at Stanford University.[2]

International Consensus Criteria[edit | edit source]

Dr. Light is one of the authors of the 2011 case definition, International Consensus Criteria.[3]

Awards[edit | edit source]

  • Javits Neuroscience Investigator Award (a seven-year research grant) from the NIH for his research on descending control of pain.[4]
  • 2010 - Won Second Place in Oral Presentations at the 2010 Annual Meeting of the American Society Anesthesiologists for A novel approach to studying the sensory pathways involved in the perception of fatigue[5]

Education[edit | edit source]

  • B.A. 1972, Hamilton College
  • Ph.D. 1977, SUNY at Upstate Medical Center
  • Postdoctoral Fellow 1977-1979, UNC-Chapel Hill

Talks & interviews[edit | edit source]

Short web seminars Science to patients / Wetenschap voor patienten

English spoken, dutch subtitles

Books[edit | edit source]

  • 2010, Chapter 11: Myalgia and Fatigue—Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes In: Translational Pain Research – From Mouse to Man[6] (Full Text)

Publications related to ME/CFS[edit | edit source]

Open Letter to The Lancet[edit | edit source]

Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Light, along with 41 colleagues in the ME/CFS field, signed the second letter.

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  3. 3.0 3.1 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, A C P; Speight, N; Vallings, R; Bateman, L; Baumgarten-Austrheim, B; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Jo, D; Lewis, D; Light, A; Marshall-Gradisnik, S; Mena, I; Mikovits, JA; Miwa, K; Murovska, M; Pall, ML; Stevens, S (2011), "Myalgic encephalomyelitis: International Consensus Criteria.", Journal of Internal Medicine, 270 (4): 327-38, doi:10.1111/j.1365-2796.2011.02428.x, PMID 21777306 
  6. Light, A.R. Vierck, C.J., and Light, K.C. (2010) Chapter 11: Myalgia and Fatigue—Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes In: Translational Pain Research – From Mouse to Man, Lawrence Kruger and Alan Light, editors; Taylor and Francis.
  7. Lindheimer, Jacob B.; Meyer, Jacob D.; Stegner, Aaron J.; Dougherty, Ryan J.; Van Riper, Stephanie M.; Shields, Morgan; Reisner, Amanda; Shukla, Sanjay K.; Light, Alan R.; Yale, Steven; Cook, Dane B. (2017), "Symptom variability following acute exercise in myalgic encephalomyelitis/chronic fatigue syndrome: a perspective on measuring post-exertion malaise", Fatigue: Biomedicine, Health & Behavior, 5 (2): 69-88, doi:10.1080/21641846.2017.1321166 
  8. Cook, Dane B.; Light, Alan R.; Light, Kathleen C.; Broderick, Gordon; Shields, Morgan R.; Dougherty, Ryan J.; Meyer, Jacob D.; VanRiper, Stephanie; Stegner, Aaron J.; Ellingson, Laura D.; Vernon, Suzanne D. (2017), "Neural Consequences of Post-Exertion Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Brain, Behavior, and Immunity, doi:10.1016/j.bbi.2017.02.009 
  9. Iacob, E., Light, A.R., Donaldson, G.W., Okifuji, A., Hughen, R.W., White, A.T., and Light, K.C. (2016) Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample. Arthritis Care and Research, Jan;68(1):132-40. doi: 10.1002/acr.22639. PMID: 26097208
  10. Light, K.C., Agarwal, N., Iacob, E., White, A.T., Kinney, A.Y., Vanhaitsma, T.A., Aizad, H., Hughen, R.W., Bateman, L., and Light, A.R. (2013) Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. Psychoneuroendocrinology, Sep 6. doi:pii: S0306-4530(13)00297-7. 10.1016/j.psyneuen.2013.08.008
  11. Meyer, Jacob D; Light, Alan R; Shukla, Sanjay K; Clevidence, Derek; Yale, Steven; Stegner, Aaron J; Cook, Dane C (2013), "Post-Exertion Malaise in Chronic Fatigue Syndrome: Symptoms and Gene Expression", Fatigue: Biomedicine, Health, & Behavior, 1 (4): 190-209, doi:10.1080/21641846.2013.838444 
  12. Light, Alan R; Bateman, Lucinda; Jo, Daehyun; Hughen, RW; Vanhaitsma, TA; White, AT; Light, Kathleen (2012), "Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome", Journal of Internal Medicine, 271 (1): 64-81, doi:10.1111/j.1365-2796.2011.02405.x 
  13. White, AT; Light, AR; Hughen, RW; Vanhaitsma, TA; Light, KC (2012), "Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls", Psychosomatic Medicine, 74 (1): 46-54, doi:10.1097/PSY.0b013e31824152ed 
  14. Light KC, White AT, Tadler S, Iacob E, Light AR. Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. Pain Research and Treatment. 2012:427869. doi: 10.1155/2012/427869
  15. Shin CH, Bateman L, Schlaberg R, Bunker AM, Leonard CJ, Hughen RW, Light AR, Light KC, Singh IR. (2011) Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome. Journal of Virology. 2011 Jul;85(14):7195-202. doi: 10.1128/JVI.00693-11.
  16. Albright, Frederick; Light, Kathleen; Light, Alan; Bateman, Lucinda; Cannon-Albright, Lisa A (2011), "Evidence for a heritable predisposition to Chronic Fatigue Syndrome", BMC Neurology, 11 (62), doi:10.1186/1471-2377-11-62 
  17. White, A.T., Light, A.R., Hughen, R.W., Bateman, L., Martins, T.B., Hill, H.R., and Light, K.C. (2010) Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. Psychophysiology, 47(4):615-24. doi: 10.1111./j.1469-8986.2010.00978.x
  18. Pollak, Kelly; Jo, Daehyun; Vanhaitsma, Timothy A; Hughen, Ron W; Light, Alan R (2010), "A novel approach to studying the sensory pathways involved in the perception of fatigue.", Journal of Critical Care, 25 (4): e18, doi:10.1016/j.jcrc.2010.08.023 
  19. Light, A.R., White, A.T., Hughen, R.W., and Light, K.C. (2009) Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects. The Journal of Pain, 10:1099-1112.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history