London criteria

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The London criteria is a definition of Myalgic Encephalomyelitis for use in research, first published in 1994[1] and updated in 2014.[2][3]

Authors[edit]

Definition[edit]

All patients should fulfill the following five criteria:

  1. A new onset of significantly abnormal levels of muscle fatigability and/or muscle weakness, precipitated by relatively minor levels of activity. Symptoms typically worsen during the next 24-48 hours.
  2. The presence of symptoms indicating the involvement of the brain and central nervous system (e.g. impaired short-term memory and concentration, disturbed sleep patterns, balance problems).
  3. Periods of impaired circulation compatible with autonomic dysfunction (e.g. facial pallor, disturbances in thermoregulation including inappropriate sweating and sensitivity to both heat and cold; postural hypotension and/or orthostatic intolerance).
  4. Fluctuation of symptoms, from hour to hour and day to day.
  5. These symptoms must have been present during the past three months (to exclude patients with the debility which often follows illnesses such as influenza).

Criticism[edit]

Learn more[edit]

See also[edit]

References[edit]

  1. EG Dowsett, E Goudsmit, A Macintyre, C Shepherd, et al., London criteria for M.E., Report from The National Task Force on Chronic Fatigue Syndrome (CFS), Post Viral Fatigue Syndrome (PVFS), Myalgic Encephalomyelitis (ME). Westcare, 1994, pp. 96-98.
  2. http://www.axfordsabode.org.uk/me/mecrit2014.htm
  3. http://www.meassociation.org.uk/2016/10/a-copy-of-the-london-criteria-as-revised-in-2014-archived-here-for-reference-purposes-15-october-2016/


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history