From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
- 2014 authors: Sandra Howes, Ellen Goudsmit, and Charles Shepherd
- 1994 authors: Elizabeth Dowsett, Ellen Goudsmit, Anne Macintyre, and Charles Shepherd
All patients should fulfill the following five criteria:
- A new onset of significantly abnormal levels of muscle fatigability and/or muscle weakness, precipitated by relatively minor levels of activity. Symptoms typically worsen during the next 24-48 hours.
- The presence of symptoms indicating the involvement of the brain and central nervous system (e.g. impaired short-term memory and concentration, disturbed sleep patterns, balance problems).
- Periods of impaired circulation compatible with autonomic dysfunction (e.g. facial pallor, disturbances in thermoregulation including inappropriate sweating and sensitivity to both heat and cold; postural hypotension and/or orthostatic intolerance).
- Fluctuation of symptoms, from hour to hour and day to day.
- These symptoms must have been present during the past three months (to exclude patients with the debility which often follows illnesses such as influenza).
- A Comparison of Case Definitions for Myalgic Encephalomyelitis and Chronic Fatigue Syndrome (2017)
- Myalgic Encephalomyelitis (ME). Criteria and clinical guidelines 2014.
- EG Dowsett, E Goudsmit, A Macintyre, C Shepherd, et al., London criteria for M.E., Report from The National Task Force on Chronic Fatigue Syndrome (CFS), Post Viral Fatigue Syndrome (PVFS), Myalgic Encephalomyelitis (ME). Westcare, 1994, pp. 96-98.