Treatment trials
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
(Redirected from Ongoing research for cures)
This page lists the recent as well as the ongoing registered medical trials on treatments for the symptoms of myalgic encephalomyelitis (ME) and post-acute sequelae of SARS-CoV-2 infection (PASC) as well as their results - if available.
Abbreviations[edit | edit source]
The following abbreviations and symbols are used in the tables below:
| Abbreviation | Meaning |
|---|---|
| NRCT | Non-randomized controlled trial |
| OLT | Open-label trial |
| RCT | Randomized controlled trial |
| Abbreviation | Meaning |
|---|---|
| LC | Long COVID |
| ME | Myalgic encephalomyelitis |
| PC | Post COVID |
| Abbreviation | Meaning |
|---|---|
| 1-4 | Trial phase 1-4 |
| n/a | Trial phase not applicable |
| Abbreviation | Meaning |
|---|---|
| C | Complementary and alternative medicine |
| D | Drug (pharmacotherapy) |
| O | Other |
| P | Psychotherapy |
| R | Rehabilitation |
| S | Supplements |
Completed trials[edit | edit source]
| Study completion | TC | Treatment | Targeted symptoms | Link / study ID | Study results | TT | TP | CS |
|---|---|---|---|---|---|---|---|---|
| 2022-01-19 | O | Biosound | many | NCT05848401 | - | OLT | n/a | LC |
| 2022-01-20 | O | Physical exercise & oxygen | cardiopulmonary | NCT04898205 | OLT | n/a | LC | |
| 2022-01-21 | O | Virtual SFCAMINA | many | NCT04593225 | - | RCT | n/a | ME |
| 2022-01-31 | D | Ruconest | neurological | NCT04705831 | - | RCT | 4 | PC |
| 2022-01-31 | D | S-1226 | respiratory | NCT04949386 | - | RCT | 2 | PC |
| 2022-02-14 | S | Formula C™ | many | NCT04828668 | inconclusive[1] | RCT | n/a | LC, PC |
| 2022-02-22 | D | Fluvoxamine (SSRI) | parosmia | NCT05216614 | - | RCT | 2 | PC |
| 2022-02-28 | R | Computerized cognitive training | cognitive | NCT05571852 | OLT | n/a | LC, PC | |
| 2022-03-07 | D | Sodium pyruvate nasal spray | many | NCT04871815 | headache-, coughing/sneezing-, hypoxemia-, dyspnea-[2] | OLT | 2/3 | LC, PC |
| 2022-03-10 | R | Inspiratory muscle training | pulmonary, strength | NCT04811859 | RCT | n/a | PC | |
| 2022-03-15 | S | Palmitoylethanolamide & Luteolin | cognitive | NCT05311852 | RCT | n/a | LC | |
| 2022-03-30 | R | Rehabilitation (online) | respiratory, neurological | NCT05074771 | OLT | n/a | PC | |
| 2022-04-22 | C | Homeopathy | many | NCT05104749 | RCT | 3 | LC, PC | |
| 2022-05-01 | R | Physical exercise (online) | pain, cardiopulmonary capacity, mood, quality of life | NCT04983394 | RCT | n/a | PC | |
| 2022-06-08 | D | Prospekta | asthenia | NCT05074888 | negligible improvements[3] | RCT | 3 | PC |
| 2022-06-29 | D | AXA1125 | muscles, fatigue | NCT05152849 | fatigue-[4] | RCT | 2 | LC |
| 2022-07-01 | R | Nordic walking | fatigue, quality of life | NCT05453188 | OLT | n/a | LC, PC | |
| 2022-07-18 | D | LYT-100 | respiratory | NCT04652518 | - | RCT | 2 | PC |
| 2022-07-30 | C | Laser acupuncture | immunological, dyspnea | NCT05271500 | RCT | n/a | PC | |
| 2022-07-31 | O | TDCS | fatigue, cognition, depression, quality of life | NCT05252481 | RCT | n/a | PC | |
| 2022-09-01 | O | Self-management | many | NCT05268523 | RCT | 1/2 | LC, PC | |
| 2022-10-10 | S | Curcumin & Boswellia serrata & Vitamin C | many | NCT05150782 | OLT | n/a | LC, PC | |
| 2022-10-13 | O | Virtual self-management | many | NCT05107440 | OLT | n/a | LC | |
| 2022-10-14 | R | Cardiorespiratory telerehabilitation | many | NCT04996212 | RCT | n/a | LC, PC | |
| 2022-11-18 | S | Bioarginina C (supplement) | physical exhaustion, systemic inflammation, endothelial function | NCT04947488 | OLT | n/a | PC | |
| 2022-11-20 | R | High tone power therapy | fitness, fatigue | NCT05217771 | RCT | n/a | PC | |
| 2022-11-30 | R | Computerized cognitive training | fatigue, cognitive | NCT05582603 | OLT | 2 | PC | |
| 2022-12-01 | R | Circuit training | fitness | NCT05323331 | RCT | n/a | PC | |
| 2022-12-04 | D | Probiotic | many | NCT05080244 | - | RCT | n/a | LC |
| 2022-12-05 | O | Vagus nerve stimulation | many | NCT05608629 | mood+, fatigue-[5] | OLT | n/a | ME |
| 2022-12-10 | R | Diagrammatic breathing & resistance training | many | NCT05543551 | OLT | n/a | PC | |
| 2022-12-20 | R | Whole body vibration training | fitness, many | NCT05119634 | RCT | n/a | PC | |
| 2022-12-20 | D | Emoxypine & Meldonium | fatigue | NCT05939622 | fatigue-[6] | RCT | 4 | PC |
| 2022-12-30 | O | Pulsed ectromagnetic field / pulmonary rehabilitation | pulmonary | NCT05379517 | RCT | n/a | PC | |
| 2022-12-30 | R | Physiotherapy (online) | fitness, quality of life | NCT04742946 | OLT | n/a | LC | |
| 2022-12-31 | D | Oxaloacetate | fatigue | NCT05273372 | fatigue--[7] | RCT | n/a | ME |
| 2022-12-31 | R | Multidisciplinary rehabilitation (online) | many | NCT04961333 | RCT | n/a | LC | |
| 2022-12-31 | O | Stellate ganglion block | many | NCT05812209 | OLT | n/a | LC | |
| 2023-01-04 | O | Vagus nerve stimulation | fatigue | NCT05679505 | RCT | n/a | PC | |
| 2023-01-06 | D | Medical marijuana (CBD) | safety of CBD | NCT04997395 | CBD is safe[8] | OLT | 2 | LC |
| 2023-01-12 | C | Homeopathy | cough, dyspnea, fatigue | NCT05715554 | OLT | n/a | PC | |
| 2023-01-15 | D | Loratidine | many | CTRI/ 2022/07/043679 | - | RCT | 4 | LC |
| 2023-01-23 | D | Low dose naltrexone & NAD+ | fatigue | NCT04604704 | - | OLT | 2 | PC |
| 2023-01-31 | R | Balneotherapy & aquatic exercise | many | NCT05765591 | RCT | n/a | PC | |
| 2023-01-31 | S | Quercetin | many | NCT05730660 | fatigue-, sleep issues-[9] | RCT | n/a | ME |
| 2023-01-31 | S | ImmunoVita (supplement) | many | NCT04301609 | no significant improvements[10] | RCT | n/a | ME |
| 2023-01-31 | R | Inspiratory muscle training | many | NCT05196529 | - | OLT | n/a | PC, ME |
| 2023-02-01 | R | Robotic assisted hand rehabilitation | health, independence, range of motion | NCT06137716 | OLT | n/a | PC, ME | |
| 2023-02-02 | R | Diaphragmatic exercises / incentive spirometer | pulmonary | NCT05787275 | RCT | n/a | PC | |
| 2023-02-22 | D | Vortioxetine (SSRI) | cognitive | NCT05047952 | cognitive=[11] | RCT | 2 | PC |
| 2023-02-28 | R | Pulmonary rehabilitation | pulmonary | NCT05496842 | OLT | n/a | PC | |
| 2023-03-02 | O | Portable oxygen concentrator | pulmonary | NCT05212831 | OLT | n/a | LC | |
| 2023-03-23 | R | Pulmonary rehabilitation | pulmonary | NCT05402007 | RCT | n/a | LC, PC | |
| 2023-03-30 | O | Vagus nerve stimulation | neuropsychological | NCT05389592 | RCT | n/a | LC, PC | |
| 2023-03-31 | O | Vagus nerve stimulation | pain | NCT05205577 | OLT | n/a | LC | |
| 2023-03-31 | D | RSLV-132 | fatigue | NCT04944121 | - | RCT | 2 | PC |
| 2023-04-21 | S | Omega 3 | many | NCT05121766 | RCT | 1 | PC | |
| 2023-05-18 | D | Dextroamphetamine | fog | NCT05597722 | - | RCT | 4 | PC |
| 2023-05-23 | O | Hydrogen water & biofeedback | many | NCT05397626 | OLT | 1 | ME | |
| 2023-05-31 | R | Cardiopulmonary exercise | many | NCT05035628 | RCT | n/a | LC | |
| 2023-05-31 | R | Physical exercise | many | NCT05204511 | OLT | 1 | LC, PC | |
| 2023-05-31 | R | Physical exercise | many | NCT06016192 | OLT | n/a | PC | |
| 2023-06-01 | C | Cupping therapy | immunological | NCT05901337 | OLT | n/a | PC | |
| 2023-06-01 | O | Hyperbaric oxygen therapy | pulmonary | NCT05977166 | OLT | n/a | PC | |
| 2023-06-06 | O | Plasma Exchange Therapy | many | NCT05445674 | RCT | 2 | PC | |
| 2023-06-30 | P | Mindfulness | many | NCT05566379 | OLT | n/a | LC, PC | |
| 2023-06-30 | P | Adhera (fatigue digital program) | many | NCT05483829 | OLT | n/a | LC | |
| 2023-07-06 | R | Osteopathy & Physiotherapy | fatigue | NCT05012826 | RCT | n/a | LC | |
| 2023-07-21 | S | Lithium | fatigue, fog | NCT05618587 | RCT | 2 | LC | |
| 2023-07-27 | D | TNX-102 SL | pain | NCT05472090 | - | RCT | 2 | PC |
| 2023-07-30 | R | Physiotherapy with neuromodulation | fatigue, sleep, quality of life | NCT05681455 | RCT | n/a | PC | |
| 2023-07-31 | D | Valacyclovir & Celecoxib (IMC-2) | fatigue, pain, POTS | Virios PR CTA | - | OLT | 2 | PC |
| 2023-07-31 | R | Resistance exercise | fitness, fatigue | NCT04900961 | OLT | n/a | LC | |
| 2023-07-31 | O | TDCS | many | NCT05780450 | OLT | n/a | LC, PC | |
| 2023-08-01 | R | Physical exercise (online) | fitness, sleep, anxiety, depression | NCT05381675 | RCT | n/a | PC | |
| 2023-08-02 | R | Cardiorespiratory rehabilitation (online) | fatigue, PEM, fitness | NCT05973136 | OLT | n/a | PC | |
| 2023-08-10 | C | Homeopathy | many | NCT06002230 | OLT | n/a | LC | |
| 2023-08-11 | D | PRS-220 | pulmonary fibrosis | NCT05473533 | - | RCT | 1 | n/a |
| 2023-08-30 | R | Sensory re-education training | disability, tactile sensation, handgrip strength | NCT05911113 | RCT | n/a | PC | |
| 2023-08-30 | R | Physical exercise | many | NCT05961462 | RCT | n/a | LC | |
| 2023-08-31 | R | Rehabilitation | fatigue | NCT05599906 | OLT | n/a | LC | |
| 2023-08-31 | D | Montelukast | respiratory | NCT04695704 | - | RCT | 3 | LC |
| 2023-09-01 | S | Magnesium & Vitamin D | many | NCT05630339 | RCT | n/a | PC | |
| 2023-09-12 | D | Metoprolol (beta blocker) | tachycardias, POTS, hypertension | NCT05096884 | - | OLT | 1 | PC |
| 2023-09-12 | D | Nirmatrelvir & Ritonavir (Paxlovid) | many | NCT05576662 | - | RCT | 2 | PC |
| 2023-09-22 | R | Inspiratory & expiratory muscle training | many | NCT05597774 | RCT | n/a | LC | |
| 2023-09-30 | R | Physical exercise | physical & mental fitness | NCT05848518 | RCT | n/a | LC, PC | |
| 2023-09-30 | P | Active coping | pain | NCT05894629 | RCT | n/a | PC | |
| 2023-09-30 | D | Sulfureous water | cardiopulmonary, inflammation | NCT06294756 | RCT | n/a | LC, PC | |
| 2023-10-01 | O | GET & CBT | many | NCT05534997 | OLT | n/a | PC | |
| 2023-10-01 | D | Meplazumab | many | NCT05813587 | RCT | 3 | PC | |
| 2023-10-04 | D | Somatropin (growth hormone) | hormonal | NCT03554265 | NRCT | 3 | PC | |
| 2023-10-18 | D | Zofin | many | NCT05228899 | RCT | 2 | LC | |
| 2023-10-30 | D | Vericiguat | fatigue, PEM | NCT05697640 | RCT | 2 | PC | |
| 2023-10-31 | D | Medical marijuana | many | NCT05467904 | RCT | n/a | LC | |
| 2023-11-01 | D | IV Rintatolimod (Ampligen) | many | NCT05592418 | RCT | 2 | PC, ME | |
| 2023-11-03 | D | Probiotic: VSL#3® | many | NCT05874089 | RCT | n/a | LC | |
| 2023-11-06 | O | Triphala & HIIT | immune system, oxidative stress | NCT06208761 | inconclusive[12] | RCT | 2 | LC |
| 2023-11-14 | R | Physical and respiratory rehabilitation | many | NCT05629884 | OLT | n/a | LC, PC | |
| 2023-11-30 | R | Telerehabilitation | many | NCT05817032 | OLT | n/a | LC | |
| 2023-11-30 | P | Cognitive training | cognitive, anxiety, depression | NCT05629897 | OLT | n/a | LC, PC | |
| 2023-11-30 | P | CBT & mindfulness | pain, anxiety, depression, insomnia | NCT05815693 | OLT | n/a | LC, PC | |
| 2023-11-30 | C | Acupuncture | fog, cognitive | NCT06144320 | RCT | n/a | PC | |
| 2023-11-30 | R | Physiotherapy | many | NCT05040893 | OLT | n/a | LC | |
| 2023-12-01 | D | Pimozide | tinitus | NCT05507372 | OLT | n/a | PC | |
| 2023-12-11 | D | Probiotic | many | NCT05975034 | RCT | n/a | LC | |
| 2023-12-28 | C | Tai chi | strength | NCT05501067 | RCT | n/a | PC | |
| 2023-12-30 | D | Fampridine | cognitive | NCT05274477 | RCT | n/a | PC | |
| 2023-12-30 | O | Stellate ganglion block & Bupivacaine | many | NCT05638620 | OLT | 1 | LC, PC | |
| 2023-12-30 | C | Yoga & self-management | many | NCT05697042 | OLT | n/a | LC | |
| 2023-12-30 | R | Rehabilitation | fatigue | NCT04836351 | OLT | n/a | PC | |
| 2023-12-31 | O | Electrical stimulation | pain, fatigue, strength, endurance | NCT05200858 | RCT | n/a | LC, PC | |
| 2023-12-31 | D | Niagen | cognitive, depression, anxiety | NCT04809974 | RCT | 4 | LC | |
| 2023-12-31 | R | Physical exercise | cardiopulmonary | NCT05566483 | OLT | n/a | LC | |
| 2023-12-31 | C | Yoga & breathing & meditation | many | NCT05139979 | RCT | n/a | LC, PC | |
| 2023-12-31 | D | Pre-probiotic | fatigue | NCT06013072 | RCT | n/a | PC | |
| 2023-12-31 | D | Remdesivir | many | NCT04978259 | OLT | 4 | LC | |
| 2023-12-31 | D | CI-581a, CI-581b (glutamate modulator) | depression | NCT05690503 | RCT | 2 | PC | |
| 2023-12-31 | C | TaiChi-DTx (software) | cognitive, physical activity | NCT05419219 | OLT | n/a | LC | |
| 2023-12-31 | O | Hyperbaric oxygen therapy | pulmonary | NCT04905888 | open RCT | 2 | LC | |
| 2023-12-31 | R | Respiratory music therapy | pulmonary, many | NCT05231512 | OLT | n/a | PC | |
| 2023-12-31 | S | Creatine | many | NCT02374112 | RCT | n/a | ME | |
| 2024-01-30 | O | Omega 3 & Telerehabilitation | fatigue, fitness, depression, anxiety | NCT06063031 | RCT | n/a | PC | |
| 2024-01-31 | D | Beclomethasone | hyposmia | NCT05970731 | RCT | 2 | LC, PC | |
| 2024-01-31 | D | Bupivacaine | many | NCT05664711 | OLT | 1 | ME | |
| 2024-01-31 | R | Online respiratory physiotherapy | pulmonary | NCT05572346 | OLT | n/a | LC | |
| 2024-01-31 | R | Sub-symptom threshold Aerobic rehabilitation | many | NCT06172803 | RCT | n/a | LC | |
| 2024-02-01 | C | Chinese herbal medicine | fatigue | NCT05684952 | RCT | 2 | LC | |
| 2024-02-01 | O | Autologous stem-cell transplantation | many | NCT05669261 | OLT | 1 | LC, PC | |
| 2024-02-01 | P | Psychology | sleep, anxiety, depression | NCT05951803 | RCT | n/a | LC | |
| 2024-02-01 | D | Solriamfetol | fatigue, cognitive | NCT04622293 | RCT | 4 | ME | |
| 2024-02-29 | R | Home-based physical training | fitness, fatigue, cognitive | NCT05360563 | OLT | n/a | PC | |
| 2024-02-29 | R | Cognitive rehabilitation | many | NCT05731570 | OLT | n/a | LC | |
| 2024-02-29 | P | Self-management | many | NCT05658536 | RCT | n/a | PC | |
| 2024-02-29 | O | Vagus nerve stimulation | dysautonomia, fatigue, dyspnea, PEM, quality of life | NCT05630040 | RCT | n/a | LC | |
| 2024-02-29 | R | Physical exercise / incentive spirometry | pulmonary, fitness | NCT06191367 | RCT | n/a | PC | |
| 2024-03-31 | R | Heart rate variability & biofeedback | many | NCT05228665 | general symptoms- [13] | OLT | n/a | LC |
Ongoing trials[edit | edit source]
| Estimated study completion | TC | Treatment | Targeted symptoms | Link / study ID | TT | TP | CS |
|---|---|---|---|---|---|---|---|
| 2024-03-27 | R | Rehabilitation | many | NCT05855356 | RCT | n/a | PC |
| 2024-03-30 | P | Psychology & breathing exercises | many | NCT05705154 | RCT | 1/2 | LC |
| 2024-03-31 | P | Cognitive behavioral therapy | fitness, fatigue, anxiety, depression | NCT05196451 | RCT | n/a | PC |
| 2024-03-31 | D | Nirmatrelvir & Ritonavir | many | NCT05823896 | RCT | 2 | LC |
| 2024-03-31 | R | Virtual home-based rehabilitation | many | NCT05298878 | OLT | n/a | LC |
| 2024-03-31 | O | Nutrition & chronobiology & physical exercise | many | NCT05719493 | OLT | n/a | ME |
| 2024-03-31 | O | Low carb diet | many | NCT05836402 | RCT | n/a | LC |
| 2024-03-31 | O | Nutrition & physical rehabilitation | many | NCT05254301 | OLT | n/a | PC |
| 2024-03-31 | O | Immunoadsorption | many | NCT05841498 | RCT | n/a | PC |
| 2024-03-31 | D | BIO 300 | respiratory | NCT04482595 | RCT | 2 | PC |
| 2024-04-06 | O | IVIG (immunotherapy) | neurological | NCT05350774 | RCT | 2 | PC |
| 2024-04-20 | R | Inspiratory muscle training | health parameters, fatigue | NCT06091358 | OLT | n/a | LC |
| 2024-04-30 | S | Oxaloacetate | fatigue | NCT05840237 | RCT | n/a | LC |
| 2024-04-30 | C | Bright light | fatigue, insomnia, anxiety, depression | NCT05677932 | RCT | n/a | LC |
| 2024-04-30 | R | Home-based physical exercise | strength, fatigue, dyspnoea | NCT06073002 | OLT | n/a | LC |
| 2024-05-31 | P | Psychoeducation | cognitive | NCT05167266 | OLT | n/a | LC |
| 2024-05-31 | O | Hydroxy gas | many | NCT06159296 | RCT | n/a | LC |
| 2024-06-01 | D | Low dose naltrexone (oral) | pain, inflammation, fatigue | NCT05430152 | RCT | 2 | PC |
| 2024-06-01 | D | Sirolimus | pulmonary fibrosis | NCT04948203 | OLT | 3 | COVID |
| 2024-06-07 | R | Pulmonary rehabilitation (online) / physical activity | fitness | NCT05299333 | RCT | n/a | PC |
| 2024-06-15 | P | Amygdala & insula retraining | fatigue | NCT05851846 | OLT | n/a | LC |
| 2024-06-28 | O | TDCS & Chlorella Pyreinodosa | biomarkers (B12, metilmalonic acid, homocysteine) | NCT06255600 | RCT | n/a | LC |
| 2024-06-28 | O | TDCS | many | NCT06074848 | OLT | 2 | PC |
| 2024-06-30 | O | TDCS | fatigue, cognition, depression, sleep, pain | NCT05753202 | OLT | n/a | PC |
| 2024-06-30 | O | Faecal microbiota transplantation | sleep, anxiety, fatigue | NCT05556733 | OLT | n/a | LC, PC |
| 2024-06-30 | S | Vitamin K2 & D3 | biomarkers | NCT05356936 | OLT | n/a | LC, PC |
| 2024-06-30 | D | Temelimab | neuropsychiatric | NCT05497089 | RCT | 2 | PC |
| 2024-06-30 | O | Hyperbaric oxygen therapy | many | NCT04842448 | RCT | 2 | PC |
| 2024-06-30 | D | LAU-7b | many | NCT05999435 | RCT | 2/3 | LC |
| 2024-06-30 | R | Breathing techniques & yoga | pulmonary, fatigue | NCT05732571 | RCT | n/a | PC |
| 2024-06-30 | O | Self-management | many | NCT06208696 | NRCT | n/a | LC |
| 2024-07-01 | D | Nirmatrelvir & Ritonavir (Paxlovid) | many | NCT05595369 | RCT | 2 | COVID, LC |
| 2024-07-30 | R | Qigong | physical health | NCT05675995 | OLT | n/a | LC, PC |
| 2024-07-30 | S | Lithium | many | NCT06108297 | OLT | 1 | LC |
| 2024-07-30 | S | Resveratrol & Quercetin | asthma, breathing | NCT05601180 | RCT | n/a | LC |
| 2024-07-31 | O | External encounter counterpulsation | fatigue | NCT05668039 | RCT | n/a | LC |
| 2024-07-31 | O | Vagus nerve stimulation | many | NCT05445427 | OLT | n/a | PC |
| 2024-07-31 | R | Incentive spirometry | many | NCT05813873 | RCT | n/a | LC |
| 2024-08-01 | O | GWAS (Genome-wide association study) | many | DecodeME | GWAS | n/a | ME |
| 2024-08-31 | O | Hyperbaric oxygen therapy | many | NCT06159309 | OLT | n/a | PC |
| 2024-08-31 | C | Acupuncture & TCM | cognitive | NCT06042777 | RCT | n/a | LC |
| 2024-08-31 | D | Cetirizine / Famotidine | many | NCT05946551 | RCT | 3 | LC |
| 2024-09-01 | D | Ivabradin | POTS | NCT05481177 | RCT | 4 | LC, PC |
| 2024-09-01 | R | Pulmonary rehabilitation | pulmonary | NCT05244044 | RCT | n/a | LC |
| 2024-09-01 | R | Diaphragmatic breathing | many | NCT06330376 | RCT | n/a | PC |
| 2024-09-25 | O | Ultrasound | fatigue | NCT06189066 | OLT | n/a | PC |
| 2024-09-30 | P | Psychotherapeutic intervention | many | NCT05453201 | OLT | n/a | LC, PC |
| 2024-09-30 | O | Electronic case management (software) | many | NCT05019963 | RCT | n/a | LC |
| 2024-09-30 | R | Cognitive training | cognitive | NCT05338749 | OLT | n/a | LC, PC |
| 2024-10-08 | R | Physical exercise (online) | fitness, cardiopulmonary, sleep | NCT05205460 | RCT | n/a | PC |
| 2024-10-31 | R | Inspiratory muscle training | fitness, blood pressure, neurovascular ctrl. | NCT06091384 | RCT | n/a | PC |
| 2024-10-31 | D | Nirmatrelvir & Ritonavir (Paxlovid) | many | NCT05668091 | RCT | 2 | LC |
| 2024-10-31 | O | RegeneCyte | many | NCT05682560 | RCT | 2 | LC |
| 2024-10-31 | R | Physical exercise | cardiopulmonary | NCT06065033 | OLT | n/a | LC, PC |
| 2024-10-31 | R | Multi-disciplinary recovery program | many | NCT05167227 | RCT | n/a | LC |
| 2024-10-31 | D | Valacyclovir & Celecoxib | fatigue | NCT06316843 | RCT | 2 | LC, PC |
| 2024-11-30 | D | Efgartigimod | POTS | NCT05633407 | RCT | 2 | PC |
| 2024-11-30 | O | Hydrogen water | fatigue, physical function, stress | NCT06227273 | OLT | n/a | ME |
| 2024-12-01 | R | NeuroFlex (brain training software) | cognitive, fatigue, depression | NCT05705193 | OLT | n/a | LC |
| 2024-12-01 | R | Cognitive rehabilitation | cognitive | NCT0567604 | OLT | n/a | LC |
| 2024-12-01 | O | Sauna | many | NCT05931497 | OLT | n/a | LC |
| 2024-12-15 | S | ImmuneRecov (proteins & supplements) | pulmonary | NCT06166030 | OLT | 3 | PC |
| 2024-12-30 | R | Breathing exercises | blood oxygen level | NCT06165835 | OLT | n/a | LC, PC |
| 2024-12-31 | C | Multimodal integrative naturopathic therapy | many | NCT04927403 | OLT | n/a | PC |
| 2024-12-31 | O | Mindfulness with Muse S™ Headband | stress, anxiety | NCT05199233 | OLT | n/a | PC |
| 2024-12-31 | S | Prednisolone & Vitamin B1, B6 and B12 | many | NCT05638633 | RCT | 3 | PC |
| 2024-12-31 | O | Photobiomodulation | oral complaints | NCT05760092 | RCT | 2 | LC |
| 2024-12-31 | R | Inspiratory muscle training | dyspnea | NCT05024474 | RCT | n/a | LC, PC |
| 2024-12-31 | R | Cognitive trainig & physical activity & mindfulness | many | NCT05846126 | RCT | n/a | LC, PC |
| 2024-12-31 | D | Metformin | many | NCT06147050 | RCT | 3 | PC |
| 2024-12-31 | D | Atorvastatin | neurocognitive | NCT04904536 | OLT | 3 | LC |
| 2024-12-31 | D | Prednisolone | cognitive | NCT05986422 | RCT | 2 | PC |
| 2024-12-31 | S | Cacao flavonoid | fatigue, handgrip strength, perceived wellbeing | NCT06064838 | OLT | n/a | LC |
| 2024-12-31 | S | Melatonin & Zinc | many | NCT05454683 | RCT | n/a | ME |
| 2024-12-31 | R | Cardiopulmonary exercise | cardiopulmonary | NCT05539950 | RCT | n/a | PC, ME |
| 2024-12-31 | S | Sodium citrate | parosmia | NCT06204432 | RCT | 2 | PC |
| 2024-12-31 | R | Physical exercise | many | NCT05094622 | OLT | n/a | PC, ME |
| 2024-12-31 | S | Floradapt Intensive GI (Probiotic) | GI inflammation, many | NCT06211062 | RCT | 2 | ME |
| 2024-12-31 | R | Interrupted sitting | PEM, cognitive, quality of life | NCT05453175 | RCT | n/a | LC |
| 2025-01-15 | R | Chiropractic | fatigue | NCT05693064 | RCT | n/a | LC |
| 2025-01-30 | O | Repeat immunoadsorption | many | NCT05629988 | OLT | n/a | PC, ME |
| 2025-01-31 | O | CPAP | fog, neuropsychological | NCT06052514 | OLT | n/a | PC |
| 2025-01-31 | S | Nicotinamide riboside & MBRT | many | NCT05703074 | RCT | 2 | LC |
| 2025-01-31 | O | TDCS | many | NCT05791812 | OLT | n/a | ME |
| 2025-02-15 | O | Umbilical cord mesenchymal stem cell therapy | caugh | NCT05808400 | NRCT | n/a | LC |
| 2025-02-28 | O | Immunoadsorption | many | NCT05710770 | RCT | 2 | PC, ME |
| 2025-02-28 | S | Nitrate | physical fatigue | NCT05618574 | OLT | 3 | LC |
| 2025-02-28 | D | DAOIB | cognitive | NCT05764538 | OLT | 2 | LC |
| 2025-03-01 | O | Vagus nerve stimulation | many | NCT05918965 | OLT | n/a | LC |
| 2025-03-30 | P | CBT & CRT | many | NCT05732285 | OLT | n/a | many |
| 2025-03-31 | O | Mild hyperthermia | many | NCT06204458 | RCT | n/a | PC |
| 2025-03-31 | S | Immulina TM (supplement) | many | NCT05524532 | RCT | n/a | PC, ME |
| 2025-03-31 | O | Apollo wearable | many | NCT06097442 | OLT | n/a | LC |
| 2025-04-15 | P | Vimida (app) | fatigue, depression, anxiety, quality of life, ... | NCT06251518 | RCT | n/a | PC |
| 2025-04-30 | C | Electro-acupuncture | many | NCT05890508 | RCT | n/a | LC |
| 2025-04-30 | P | Mindfulness | mental health | NCT05676008 | OLT | n/a | LC |
| 2025-04-30 | S | N-acetylcysteine | many | NCT0454216 | RCT | 2 | ME |
| 2025-05-15 | D | Amantadine | cognitive, mood | NCT06055244 | OLT | 1 | PC |
| 2025-05-15 | D | Fluvoxamine | many | NCT05874037 | RCT | 2/3 | LC |
| 2025-05-18 | D | Fluvoxamine & Metformin | fatigue | NCT06128967 | RCT | 3 | LC |
| 2025-05-31 | D | BC007 | many | NCT05911009 | RCT | 2 | PC |
| 2025-05-31 | D | Efgartigimod | POTS | NCT05918978 | OLT | 2 | PC |
| 2025-06-01 | S | Pycnogenol | many | NCT05890534 | RCT | 3 | PC |
| 2025-06-01 | R | Physical exercise | many | NCT05877534 | RCT | n/a | PC |
| 2025-06-30 | R | Physical exercise | cardiovascular | NCT06168006 | RCT | n/a | PC |
| 2025-07-19 | C | Acupuncture | fatigue | NCT05212688 | RCT | 2 | LC |
| 2025-07-30 | O | Diet & fasting | many | NCT06214455 | OLT | n/a | LC |
| 2025-07-31 | D | AER002 | many | NCT05877508 | RCT | 2 | LC |
| 2025-07-31 | R | Physical exercise (sensors + app) | fitness, quality of life | NCT05922865 | OLT | n/a | LC |
| 2025-08-31 | O | Vagus nerve stimulation | fatigue | NCT06170645 | RCT | n/a | ME |
| 2025-08-31 | O | Hyperbaric oxygen therapy | neurocognitive | NCT06118138 | OLT | n/a | PC |
| 2025-08-31 | D | Anakinra | respiratory | NCT05926505 | RCT | 2/3 | LC, PC |
| 2025-08-31 | O | Stellate ganglion block | parosmia | NCT06255600 | RCT | 2 | PC |
| 2025-09-01 | D | VIX001 | cognitive, neurological | NCT05947617 | OLT | 1 | LC, PC |
| 2025-09-01 | R | Physical exercise | fatigue, fitness | NCT06142240 | OLT | n/a | LC |
| 2025-09-30 | P | Balance acceptance and commitment | many | NCT06231238 | RCT | 2 | LC, PC |
| 2025-09-30 | R | Supervised computerized active program | cognitive, emotional, functional | NCT06315894 | OLT | n/a | LC, PC |
| 2025-11-01 | S | Ciwujia granules | many | NCT06245642 | RCT | 4 | ME |
| 2025-11-01 | S | Testofen | many | NCT05795816 | RCT | 3 | LC |
| 2025-12-01 | R | Physical and cognitive exercising | many | NCT05218174 | RCT | n/a | LC, PC |
| 2025-12-01 | D | Amantadine | cognitive, fatigue, anxiety, depression | NCT06234462 | RCT | 2 | LC |
| 2025-12-01 | D | Remdesivir | many | NCT05911906 | RCT | 4 | LC |
| 2025-12-20 | O | HB-adMSCs (allogeneic) | many | NCT05126563 | RCT | 2 | PC |
| 2025-12-30 | O | Hyperbaric oxygen therapy | many | NCT06082518 | OLT | n/a | PC |
| 2025-12-31 | O | IVIG | many | NCT06159283 | RCT | 2 | LC, PC |
| 2025-12-31 | R | Water-based activity | fatigue, cognitive | NCT06142253 | OLT | n/a | LC |
| 2025-12-31 | D | Imatinib / Infliximab | many | NCT05220280 | OLT | 4 | LC |
| 2025-12-31 | R | Rehabilitation & exercise | fatigue | NCT06156176 | RCT | n/a | LC, PC |
| 2025-12-31 | D | Ensitrelvir | many | NCT06161688 | RCT | 2 | LC |
| 2025-12-31 | C | Complementary & Integrative medicine online | many | NCT06004362 | RCT | n/a | PC |
| 2025-12-31 | D | Ibudilast | many | NCT05513560 | RCT | 3 | PC |
| 2026-01-31 | P | Mind body intervention | many | NCT06045338 | OLT | n/a | LC |
| 2026-02-28 | C | TCM | many | NCT06095258 | RCT | 2 | LC |
| 2026-02-28 | O | Stem cell therapy | neurological | NCT06156241 | OLT | 1 | LC |
| 2026-03-01 | S | MCTs & Safflower oil | fog | NCT05705648 | RCT | n/a | PC |
| 2026-03-30 | R | Comprehensive rehabilitation | fatigue | NCT06156202 | RCT | n/a | LC |
| 2026-03-31 | D | AT1001 (Larazotide) | many | NCT05747534 | RCT | 2 | LC |
| 2026-03-31 | D | Lp299v | many | NCT05227170 | RCT | n/a | LC, PC |
| 2026-04-01 | O | Hyperbaric oxygen therapy | many | NCT06267300 | RCT | 3 | PC |
| 2026-04-01 | P | Lightning Process | many | NCT05236465 | OLT | n/a | ME |
| 2026-04-28 | D | Nirmatrelvir & Ritonavir (Paxlovid) | many | NCT05852873 | RCT | 3 | PC |
| 2026-05-15 | O | Stellate ganglion block | parosmia | NCT06055270 | RCT | 3 | PC |
| 2026-06-01 | R | Breath control technique | many | NCT05851859 | OLT | n/a | LC |
| 2026-06-11 | D | Rapamycin | many | NCT06257420 | OLT | n/a | ME |
| 2026-08-01 | R | Incentive spirometrer respiratory training | respiratory | NCT06231225 | OLT | n/a | LC |
| 2026-12-01 | O | Diet & self-management (online) | many | NCT05057676 | OLT | n/a | many |
| 2026-12-31 | D | Low dose naltrexone | POTS | NCT05363514 | RCT | 4 | n/a |
| 2028-01-31 | R | Smell training and trigeminal nerve stimulation | parosmia | NCT05855369 | RCT | 2/3 | LC, PC |
| 2028-03-01 | D | Pregabalin | many | NCT05967052 | RCT | 2 | ME |
| 2028-09-30 | O | Weight loss | fitness | NCT05880108 | RCT | n/a | LC |
| 2028-09-30 | O | Anti-inflammatory diet | fatigue, fitness | NCT05977179 | RCT | n/a | LC, PC |
| 2029-03-31 | R | Cognitive rehabilitation | many | NCT06086379 | RCT | n/a | LC, PC |
| 2029-12-30 | D | Baricitinib | cognitive | NCT05858515 | RCT | 2 | PC |
