Vitamin C

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Vitamin C, also known as ascorbic acid, is a water-soluble vitamin found particularly in citrus fruits and green vegetables.

Function[edit | edit source]

High levels of vitamin C are found in the pituitary, adrenal gland, pancreas, liver, spleen and brain.[1]

Mast cell activation disorder[edit | edit source]

Numerous studies have found Vitamin C to be inversely correlated with histamine and that the administration of Vitamin C reduces blood histamine levels.[2][3][4] It does this potentially through several mechanisms: by inhibiting mast cell production; by increasing diamine oxidase (an enzyme that breaks down histamine); by inhibiting mast cell degranulation (and the release of histamine in the first place),[5] and by inhibiting histidine decarboxylase (the enzyme that forms histamine).[6]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Vitamin neurotoxicity". Mol Neurobiology. 
  2. Clemetson, C. A. (April 1980), "Histamine and ascorbic acid in human blood", The Journal of Nutrition, 110 (4): 662–668, ISSN 0022-3166, PMID 7365537 
  3. Johnston, C. S.; Martin, L. J.; Cai, X. (April 1992), "Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis", Journal of the American College of Nutrition, 11 (2): 172–176, ISSN 0731-5724, PMID 1578094 
  4. Johnston, CS (December 1996). "Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults". J Am Coll Nutr. 
  5. Mio, M (1999). "Ultraviolet B (UVB) light-induced histamine release from rat peritoneal mast cells and its augmentation by certain phenothiazine compounds". Immunopharmacology. 
  6. Molderings, Gerhard (2016). "Pharmacological treatment options for mast cell activation disease". Naunyn Schmiedebergs Arch Pharmacol. 


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history