Chronic fatigue syndrome
One six year longitudinal MRI study found that Chronic Fatigue Syndrome (per Fukuda & Canadian Consensus Criteria) is associated with decreases in white matter, gray matter and blood volume deficits in the brain as compared to healthy controls.
A 2017 study by Natelson, et al, showed that:
- patients with chronic fatigue syndrome (CFS) have higher brain ventricular lactate, more abnormal spinal fluids, lower brain glutathione, and reduced cerebral blood flow than controls,
- psychiatric comorbidity does not influence any of these potential biological markers of CFS,
- 50% of the patients had more than one of these abnormalities, and
- a subgroup of CFS patients with brain abnormalities may have an underlying encephalopathy producing their illness.
- "Microglia in Fibromyalgia & Chronic Fatigue Syndrome", About Health, 22 Feb 2016.
Talks & interviews
- Shan, ZY; Kwiatek, R; Burnet, R; Del Fante, P; Staines, DR; Marshall-Gradisnik, SM; Barnden, LR (2016-04-28), "Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study", Journal of magnetic resonance imaging: JMRI, PMID 27123773, doi:10.1002/jmri.25283
- Jaime S (2016-05-05), "Progressive Brain Changes in Patients with Chronic Fatigue Syndrome: Are our Brains Starved of Oxygen?", #MEAction
- Natelson, Benjamin; Mao, Xiangling; Stegner, Aaron J; Lange, Gudrun; Vu, Diana; Blate, Michelle; Kang, Guoxin; Soto, Eli; Kapusuz, Tolga; Shungu, Dikoma C (2017), "Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity", Journal of the Neurological Sciences, 375: 411-416, doi:10.1016/j.jns.2017.02.046