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Chronic fatigue syndrome[edit]

Main article: Neurology of ME/CFS

One six year longitudinal MRI study found that Chronic Fatigue Syndrome (per Fukuda & Canadian Consensus Criteria) is associated with decreases in white matter, gray matter and blood volume deficits in the brain as compared to healthy controls.[1][2]

A 2017 study by Natelson, et al, showed that:

  • patients with chronic fatigue syndrome (CFS) have higher brain ventricular lactate, more abnormal spinal fluids, lower brain glutathione, and reduced cerebral blood flow than controls,
  • psychiatric comorbidity does not influence any of these potential biological markers of CFS,
  • 50% of the patients had more than one of these abnormalities, and
  • a subgroup of CFS patients with brain abnormalities may have an underlying encephalopathy producing their illness.[3]



Notable studies[edit]

Talks & interviews[edit]

Learn more[edit]


  1. Shan, ZY; Kwiatek, R; Burnet, R; Del Fante, P; Staines, DR; Marshall-Gradisnik, SM; Barnden, LR (2016-04-28), "Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study", Journal of magnetic resonance imaging: JMRI, PMID 27123773, doi:10.1002/jmri.25283 
  2. Jaime S (2016-05-05), "Progressive Brain Changes in Patients with Chronic Fatigue Syndrome: Are our Brains Starved of Oxygen?", #MEAction 
  3. Natelson, Benjamin; Mao, Xiangling; Stegner, Aaron J; Lange, Gudrun; Vu, Diana; Blate, Michelle; Kang, Guoxin; Soto, Eli; Kapusuz, Tolga; Shungu, Dikoma C (2017), "Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity", Journal of the Neurological Sciences, 375: 411-416, doi:10.1016/j.jns.2017.02.046 

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history