Brain

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Chronic fatigue syndrome[edit | edit source]

One six year longitudinal MRI study found that Chronic Fatigue Syndrome (per Fukuda & Canadian Consensus Criteria) is associated with decreases in white matter, gray matter and blood volume deficits in the brain as compared to healthy controls.[1][2]

A 2017 study by Natelson, et al, showed that:

  • patients with chronic fatigue syndrome (CFS) have higher brain ventricular lactate, more abnormal spinal fluids, lower brain glutathione, and reduced cerebral blood flow than controls,
  • psychiatric comorbidity does not influence any of these potential biological markers of CFS,
  • 50% of the patients had more than one of these abnormalities, and
  • a subgroup of CFS patients with brain abnormalities may have an underlying encephalopathy producing their illness.[3]

Microglia[edit | edit source]

Microglia

Notable studies[edit | edit source]

  • 2018, Brain function characteristics of chronic fatigue syndrome: A task fMRI study[4] (Full Text)
  • 2018, Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[5]
  • 2017, Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study[6]
  • 2017, CNS findings in chronic fatigue syndrome and a neuropathological case report[7]
  • 2016, Relative increase in choline in the occipital cortex in chronic fatigue syndrome[8]

Talks & interviews[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Shan, ZY; Kwiatek, R; Burnet, R; Del Fante, P; Staines, DR; Marshall-Gradisnik, SM; Barnden, LR (2016-04-28), "Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study", Journal of magnetic resonance imaging: JMRI, doi:10.1002/jmri.25283, PMID 27123773 
  2. Jaime S (2016-05-05), "Progressive Brain Changes in Patients with Chronic Fatigue Syndrome: Are our Brains Starved of Oxygen?", #MEAction 
  3. Natelson, Benjamin; Mao, Xiangling; Stegner, Aaron J; Lange, Gudrun; Vu, Diana; Blate, Michelle; Kang, Guoxin; Soto, Eli; Kapusuz, Tolga; Shungu, Dikoma C (2017), "Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity", Journal of the Neurological Sciences, 375: 411-416, doi:10.1016/j.jns.2017.02.046 
  4. Zack Y. Shan, Kevin Finegan, Sandeep Bhuta, Timothy Ireland, Donald R. Staines, Sonya M. Marshall-Gradisnik, Leighton R. Barnden. (2018) Brain function characteristics of chronic fatigue syndrome: A task fMRI study. NeuroImage: Clinical, Volume 19, 2018, Pages 279-286. https://doi.org/10.1016/j.nicl.2018.04.025
  5. Nakatomi, Y; Kuratsune, H; Watanabe, Y (2018), "Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Brain Nerve, 70 (1): 19-25, doi:10.11477/mf.1416200945, PMID 29348371 
  6. Finkelmeyer, Andreas; He, Jiabao; Maclachlan, Laura; Watson, Stuart; Gallagher, Peter; Newton, Julia L.; Blamire, Andrew M. (2018), "Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study", NeuroImage: Clinical, 17: 24-30, doi:10.1016/j.nicl.2017.09.024, PMID 29021956 
  7. Ferrero, Kimberly; Silver, Mitchell; Cocchetto, Alan; Masliah, Eliezer; Langford, Dianne (2017), "CNS findings in chronic fatigue syndrome and a neuropathological case report", Journal of Investigative Medicine, doi:10.1136/jim-2016-000390 
  8. https://www.ncbi.nlm.nih.gov/pubmed/12197861


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history