Body temperature

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The normal human body temperature range is typically stated as 36.5–37.5 °C (97.7–99.5 °F). The average internal temperature is 37.0 °C (98.6 °F). It is typically maintained within this range by thermoregulation. Body temperature normally fluctuates over the day following circadian rhythms, with the lowest levels around 4 a.m. and the highest in the late afternoon.

Core temperature is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system.

Pathophysiology[edit | edit source]

ME/CFS[edit | edit source]

Temperature dysregulation[edit | edit source]

Temperature dysregulation, heat intolerance and cold intolerance are common symptoms of ME/CFS, and are is recognised in the Canadian Consensus Criteria as a neuroendocrine symptom.

  • 53.9% - 58.7% of the 2073 patients in a Belgian study of 2001 reported symptom exacerbation in extremes of temperature.[1]
  • Katrina Berne reports a prevalence of 75-80% for heat/cold intolerance.[2]

In the London criteria for ME, sensitivity to both heat and cold is mentioned under the criteria of periods of impaired circulation compatible with autonomic dysfunction.[3]

Temperature instability[edit | edit source]

Temperature instability and heat or cold intolerance are ME symptoms recognized in the International Consensus Criteria.[4]

Loss of thermostatic stability and intolerance of extremes of temperatures are separate diagnostic criteria in the International Consensus Criteria for ME. Indicators of temperature instability are listed as subnormal body temperature, marked fluctuations of temperature throughout the day; sweating episodes, recurrent feelings of feverishness with or without low grade fever, and cold extremities, e.g. fingers and toes.[4]

References[edit | edit source]

neuroendocrine relating to hormones that influence the nervous system

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.