Diamine oxidase

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Diamine oxidase (DAO), also known as histaminase, is an enzyme that breaks down histamine. The highest concentrations of DAO are found in the digestive tract and the placenta.[1]

Supplementation[edit | edit source]

DAO is available in supplement form and is sometimes taken by individuals with mast cell activation disorder.

Magnesium is an important cofactor in the production of DAO and magnesium deficiency may result in decreased DAO activity and excess histamine levels.[2]

Copper, Vitamin B6[3] and Vitamin C are other important DAO cofactors.

Heparin increases the activity of DAO in the bloodstream.[4]

See also[edit | edit source]

References[edit | edit source]

  1. Agúndez, JA; Ayuso, P; Cornejo-García, JA; Blanca, M; Torres, MJ; Doña, I; Salas, M; Blanca-López, N; Canto, G; Rondon, C; Campo, P; Laguna, JJ; Fernández, J; Martínez, C; García-Martín, E (2012), "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs", PLOS ONE, 7 (11): e47571, doi:10.1371/journal.pone.0047571, PMID 23152756 
  2. Nishio, A.; Ishiguro, S.; Miyao, N. (1987), "Specific change of histamine metabolism in acute magnesium-deficient young rats", Drug-Nutrient Interactions, 5 (2): 89–96, ISSN 0272-3530, PMID 3111814 
  3. Martner-Hewes, P. M.; Hunt, I. F.; Murphy, N. J.; Swendseid, M. E.; Settlage, R. H. (1986-12-01), "Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers.", The American Journal of Clinical Nutrition, 44 (6): 907–913, ISSN 0002-9165, PMID 3098085, retrieved 2016-11-09 
  4. Klocker, Josef; Perkmann, Reinhold; Klein-Weigel, Peter; Mörsdorf, Gabriele; Drasche, Astrid; Klingler, Anton; Fraedrich, Gustav; Schwelberger, Hubert G. (January 2004), "Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase", Vascular Pharmacology, 40 (6): 293–300, doi:10.1016/j.vph.2004.02.002, ISSN 1537-1891, PMID 15063833 


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history