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A number of blood abnormalities have been detected in patients who present with ME/CFS, it is hypothesised that these may result in a number of symptoms that are experienced by patients, though taking steps to address various of these abnormalities has resulted in symptomatic relief for a number of patients, a reliable 'cure' has yet to result from blood work.


A high proportion of ME/CFS patients have been shown via a Dual Tag Test to have significantly lower blood volume than healthy controls. [1][2] Dr. Nancy Klimas who was a member of the team who showed this has since been quoted as saying by way of a Layman's explanation: “You guys are about a litre short in blood volume, ok? If I’m sitting at five litres, you’re sitting at four. So, you’re really, really sensitive to blood volume changes. If you’re a little dry, you crash. ” [3]

One study found significantly increased quantities of stomatocytes in the blood of CFS patients. Stomatocytes are red blood cells that have lost their concave shape, usually due to a membrane defect. [4]

During the early stages of the illness a number of circulating immune markers in the blood have been noted. [5]

Symptoms Resulting from Abnormalities[edit]

The various forms of Orthostatic intolerance that a number of ME/CFS patients suffer have been linked to under-oxygenation of the brain [6] due to a combination of red blood cell abnormalities and low blood volume. It has also been suggested that blood pressure and other circulatory system abnormalities contribute to this under-oxygenation. [7] However others state that this may be a direct result of the Adrenal system instead.

Proposed Causes for Blood Abnormalities[edit]

Abnormality Treatments and Adjustments[edit]

Learn more[edit]

See also[edit]


  2. Circulating Blood Volume in Chronic Fatigue Syndrome
  3. Citation Needed
  6. Citation Needed
  7. Citation Needed

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history