Peripheral blood mononuclear cell
Peripheral Blood Mononuclear Cells or PBMCs are types of white blood cells with a round nuclei, including lymphocytes, macrophages and monocytes, but not granulocytes (polymorphonuclear leucocytes like neutophils, eosinophils and basophils).
See also[edit | edit source]
Notable studies[edit | edit source]
- 2001, G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway(Abstract)
- 2017, Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients(Full Text)
- 2018, A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy(Abstract)
- 2018, A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)(Full text)
Learn more[edit | edit source]
References[edit | edit source]
- Oellerich, Michael; Dasgupta, Amitava (2015). "Chapter 9 - Intracellular concentrations of immunosuppressants". Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring. Elsevier. p. 200. ISBN 9780128011331.
- Brooker, Chris (2008). Churchill Livingstone Medical Dictionary E-Book. Elsevier Health Sciences. pp. 206, 369. ISBN 9780080982458.
- Bittersohl, Heike; Steimer, Werner (2016). "Intracellular concentrations of immunosuppressants". Elsevier: 199–226. doi:10.1016/b978-0-12-800885-0.00009-6. ISBN 9780128008850.
- Roelens, Simon; Herst, C. Vincent; D'Haese, Anne; De Smet, Karen; Frémont, Marc; De Meirleir, Kenny; Englebienne, Patrick (Jan 1, 2001). "G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway". Journal of Chronic Fatigue Syndrome. 8 (3-4): 63–82. doi:10.1300/J092v08n03_07. ISSN 1057-3321.
- Nguyen, T.; Johnston, S.; Chacko, A.; Gibson, D.; Cepon, J.; Smith, D.; Staines, D.; Marshall-Gradisnik, S. (2017), "Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients", Asian Pac J Allergy Immunol, 35 (2): 75-81, doi:10.12932/AP0771
- Xu, Jiabao; Potter, Michelle; Tomas, Cara; Elson, Jo; Morten, Karl; Poulton, Joanna; Wang, Ning; Jin, Hanqing; Hou, Zhaoxu (2018). "A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy". The Analyst. doi:10.1039/C8AN01437J. ISSN 0003-2654.
- Davis, R. W.; Wilhelmy, J.; Nemat-Gorgani, M.; Kashi, A.; Esfandyarpour, R. (Apr 25, 2019). "A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)". Proceedings of the National Academy of Sciences: 201901274. doi:10.1073/pnas.1901274116. ISSN 0027-8424. PMID 31036648.
chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.