Vitamin B6 (pyridoxine) is a co-factor in amino acid metabolism, the folate cycle, and the biosynthesis of neurotransmitters, including dopamine, GABA, melatonin, norepinephrine, and serotonin.
Vitamin B6 is a cofactor for diamine oxidase, the enzyme that breaks down histamine. It is also a cofactor (in pyridoxal 5'-phosphate form) of histidine decarboxylase, the enzyme that catalyzes the decarboxylation of histidine to form histamine.
One very small study found decreased functional status of several B vitamins including pyroxidine, riboflavin and thiamine.
- ↑ Heap, L. C.; Peters, T. J.; Wessely, S. (1999-04-01), "Vitamin B Status in Patients with Chronic Fatigue Syndrome", Journal of the Royal Society of Medicine, 92 (4): 183–185, doi:10.1177/014107689909200405, ISSN 0141-0768, PMID 10450194, retrieved 2016-11-09
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