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Gamma aminobutyric acid (GABA), is a neurotransmitter made from the amino acid glutamate. GABA is the chief inhibiting, or calming neurotransmitter in the brain, functioning as a brake on the neural circuitry during stress. Low GABA levels are associated with restlessness, anxiety, insomnia and a low mood/depression. GABA works to balance glutamate (excitatory) in the brain. GABA is the brake pedal on a car while glutamate is the gas pedal.
Supplements to support GABA and glutamate are:
- amino acids GABA
- N-acetyl-cysteine (NAC)
- vitamin B6
- vitamin D
- Omega 3 fatty acid, and
- inositol
Notable studies[edit | edit source]
- 2005, GABA and glutamate systems as therapeutic targets in depression and mood disorders
- 2005, Beyond monoamines: glutamatergic function in mood disorders
- 2006, Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans
- 2007, Thorne Research, Inc: Gamma-Aminobutyric Acid (GABA). Alternative Medicine Review, 2007; 12(3)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- Kendell, Steven F.; Krystal, John H.; Sanacora, Gerrard (February 2005). "GABA and glutamate systems as therapeutic targets in depression and mood disorders". Expert Opinion on Therapeutic Targets. 9 (1): 153–168. doi:10.1517/14728188.8.131.52. ISSN 1744-7631. PMID 15757488.
- Kugaya, Akira; Sanacora, Gerard (Oct 2005). "Beyond monoamines: glutamatergic function in mood disorders". CNS spectrums. 10 (10): 808–819. doi:10.1017/s1092852900010403. ISSN 1092-8529. PMID 16400244.
- Abdou, Adham M.; Higashiguchi, S.; Horie, K.; Kim, Mujo; Hatta, H.; Yokogoshi, H. (2006). "Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans". BioFactors (Oxford, England). 26 (3): 201–208. doi:10.1002/biof.5520260305. ISSN 0951-6433. PMID 16971751.
glutamate (Glu) - Glutamate is one of the amino acids used by the body to make proteins. It is a salt or ester of glutamic acid, and the terms glutamate and glutamic acid are often used interchangeably. It also functions as the principal excitatory neurotransmitter in the brain.
central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.