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Valaciclovir (UK) or valacyclovir (US) is a generic antiviral drug used against most herpesviruses. It does not cure herpes, but helps reduce the viral expression, by interrupting the replication of viral DNA.[1]

Valaciclvir is the international nonproprietary name used by the World Health Organization (WHO). The non-generic or trade names are Valtrex and Zelitrex, manufactured by GlaxoSmithKline.

It is available by prescription only, worldwide, and is administered orally.

Once in the body, valaciclovir is converted to aciclovir (UK) or acyclovir (US).

Treatment with Valacyclovir reduces the number of Epstein-Barr virus-infected B cells, but not the number of EBV DNA copies within each infected cell.[2]

Use in ME/CFS[edit | edit source]

Some ME/CFS specialists prescribe valaciclvir to help mitigate the effects of the Epstein-Barr virus which may be reactivated in ME/CFS. Dr. A Martin Lerner studied the efficacy of higher doses of Valtrex on ME/CFS and concluded that it increased physical functioning, improved heart functioning, and decreased Epstein-Barr virus antibody levels. [3]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Wikipedia - Valaciclovir
  2. Hoshino, Yo; Katano, Harutaka; Zou, Ping; Hohman, Patricia; Marques, Adriana; Tyring, Stephen K.; Follmann, Dean; Cohen, Jeffrey I. (November 2009), "Long-Term Administration of Valacyclovir Reduces the Number of Epstein-Barr Virus (EBV)-Infected B Cells but Not the Number of EBV DNA Copies per B Cell in Healthy Volunteers", Journal of Virology, 83 (22): 11857–11861, doi:10.1128/JVI.01005-09, ISSN 0022-538X, PMC 2772668Freely accessible, PMID 19740997, retrieved Nov 9, 2016 
  3. ME/CFS Treatment Resource Guide for Practitioners - A. Martin Lerner (pdf)

World Health Organization (WHO) - "A specialized agency of the United Nations that is concerned with public health. It was established on 7 April 1948, and is headquartered in Geneva, Switzerland. The WHO is a member of the United Nations Development Group. Its predecessor, the Health Organization, was an agency of the League of Nations." The International Statistical Classification of Diseases and Related Health Problems (ICD) is maintained by WHO. (Learn more:

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

antibody - Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.