Zofin or Organicell Flow is an unapproved treatment that has been used on a number of patients severely ill with long-lasting COVID-19 symptoms under a compassionate use authorization. Zofin is a biological product derived from the human amniotic fluid (HAF) donated from the births of healthy, newborn babies; it is administered by intravenous infusion.
Zofin is produced by the company Organicell which states that it "contains over 300 growth factors, cytokines, and chemokines as well as other extracellular vesicles/nanoparticles derived from amniotic stem and epithelial cells" including the proteins CD63, CD81, and CD9 in addition to high expression of CD133.
Theory[edit | edit source]
According to Organicell, pro-inflammatory cytokines believed to be targeted by Zofin include tumor necrosis factor (TNF), IL-6, and IL-8, and published research states that targeting these may "reduce the severity of symptoms associated with elevated immune response".
Theory[edit | edit source]
Evidence[edit | edit source]
Clinicians[edit | edit source]
Risks and safety[edit | edit source]
Zofin has not yet been approved for use and clinical trials remain ongoing.
Risks, side effects and safety are largely unknown.
Costs and availability[edit | edit source]
Zofin is not yet an approved drug and availability is limited to special authorizations.
See also[edit | edit source]
Learn more[edit | edit source]
- Organicell reports positive results from compassionate use of Organicell Flow - Organicell
- Clinical trial NCT04384445
References[edit | edit source]
- Organicell (May 27, 2020). "Organicell Reports Positive Results from Compassionate Use of Organicell Flow in Severely Ill COVID-19 Patients". Retrieved Dec 13, 2020.
- Caldwell, Blair (Nov 23, 2020). "Savannah doctor providing treatment for long-term COVID-19 effects". WTOC. Retrieved Dec 13, 2020.
extracellular vesicle - An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)
adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.