N-acetylcysteine

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N-acetylcysteine also known as Acetylcysteine or N-acetyl-L-cysteine (NAC) increases levels of glutathione (GSH), the most common antioxidant in the body. Taking GSH directly is costly and inefficient, NAC is a more efficient and economical means delivering GSH to cells.[1] NAC is a pro-drug for l-cysteine which enables cells to synthesise Glutathione providing antioxidant benefits.[2]

Evidence[edit | edit source]

In a presentation to the 2016 IACFS/ME conference Dr Dikoma Shungu of Cornell University gave a presentation on a trial of NAC in ME/CFS patients. [3] Previously his team had found a 36% deficit of the tissue anti-oxidant occipital cortex glutathione (GSH) in the cortical areas of the brains ofME/CFS patients.[4]

The trial supplemented patients (meeting the CDC criteria for CFS} with 1800mg daily of GSH precursor n-acetylcysteine for 4 weeks and looked at levels of cortical GSH. The study found that cortical GSH had increased in patients and that CFS symptoms (as assessed with the CDC CFS symptom inventory) were significantly reduced.[5]

Clinical use[edit | edit source]

No official use for ME/CFS currently.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history