Martin Pall

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Martin L. Pall, PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.[1] He states that he developed Chronic Fatigue Syndrome (CFS) from a varicella zoster virus infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.[2]

Dr. Pall was one of the authors of the International Consensus Criteria.[3]

Education[edit | edit source]

  • 1962 - B.A., Johns Hopkins University, Baltimore, MD
  • 1968 - Ph.D., California Institute of Technology, Pasadena, CA

NO/ONOO-cycle[edit | edit source]

Dr. Pall developed the Nitric Oxide Cycle Theory, also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), Multiple Chemical Sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.[4]

He believes that certain over-the-counter supplements, such as fish oil, CoQ10, vitamin E, NAC (N-acetylcysteine), magnesium, and other antioxidants, can help downregulate the oxidation caused by the nitric oxide cycle.[5] He believes Vitamin B12 injections can also be a potent nitric oxide scavenger.[6]

Book[edit | edit source]

Articles[edit | edit source]

Talks and interviews[edit | edit source]

Publications on ME/CFS[edit | edit source]

  • 2011, Myalgic encephalomyelitis: International Consensus Criteria.[9]
  • 2011, Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?[10]
  • 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease.[11]
  • 2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due.[12]
  • 2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.[13]
  • 2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients[14] (Abstract)
  • 2002, Chronic fatigue syndrome/myalgic encephalitis.[15] (Full Access)
  • 2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.[16] (Full Text)
  • 2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.[17] (Abstract)
  • 2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. [18]
  • Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation[19]
  • 2000, Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger [20]

Online presence[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. http://www.smb.wsu.edu/faculty-trainees-and-staff/faculty.
  2. http://www.prohealth.com/library/showarticle.cfm?libid=12966
  3. Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, A C P; Speight, N; Vallings, R; Bateman, L; Baumgarten-Austrheim, B; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Jo, D; Lewis, D; Light, A; Marshall-Gradisnik, S; Mena, I; Mikovits, JA; Miwa, K; Murovska, M; Pall, ML; Stevens, S (2011), "Myalgic encephalomyelitis: International Consensus Criteria.", Journal of Internal Medicine, 270 (4): 327-38, doi:10.1111/j.1365-2796.2011.02428.x, PMID 21777306 
  4. http://www.prohealth.com//library/showArticle.cfm?libid=12896
  5. http://www.prohealth.com/library/showarticle.cfm?libid=16224
  6. http://www.investinme.eu/IIMEC2.shtml
  7. Pall, Martin L. (2007), Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome (book), ISBN 978-0789023889 
  8. http://www.investinme.eu/IIMEC2.shtml
  9. Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles AC, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell DS, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall-Gradisbik S, Mena I, Mikovits JA, Miwa K, Murovska M, Pall ML, Stevens S. (2011). Myalgic encephalomyelitis: International Consensus Criteria. Journal of Internal Medicine, 270 (4):327-38. doi: 10.1111/j.1365-2796.2011.02428.x. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21777306
  10. Höck, Anna Dorothea; Pall, Martin L. (2011), "Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?", Medical Hypotheses, 76 (2): 208-13, doi:10.1016/j.mehy.2010.09.032, PMID 20980105 
  11. Pall, ML. (2008). Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease. Medical Hypotheses, 71 (4):537-41. doi:10.1016/j.mehy.2008.05.023. Epub 2008 Jul 29. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18667279
  12. Pall ML. (2005). Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due. Medical Hypotheses, 65 (3):631-3. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15936892.
  13. Smirnova IV, Pall ML. (2003). Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients. Molecular and Cellular Biochemistry, 248 (1-2):93-5. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12870659
  14. Martin L. Pall. (2002). Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients. Journal of Chronic Fatigue Syndrome, Vol. 10, Iss. 2, pp. 37-41.
  15. Pall, ML. (2002). Chronic fatigue syndrome/myalgic encephalitis. British Journal of General Practice, 52 (482):762. PMID:12236283
  16. Pall, ML. (2001). Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Medical Hypotheses, 57 (2):139-45. PMID:11461161
  17. Pall ML, Satterlee JD. (2001). Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. Annals of the New York Academy of Science, 933.323-9. PMID:12000033
  18. Pall, Martin (2000), "Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome", Medical Hypotheses, 54 (1): 115-125, doi:10.1054/mehy.1998.0825, PMID 10790736 
  19. Pall, Martin L. (2000), "Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation", Journal of Chronic Fatigue Syndrome, 7 (4): 45-58, doi:10.1300/J092v07n04_05 
  20. Pall, Martin (2000), "Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger", Journal of Chronic Fatigue Syndrome, 8 (2): 39-44, doi:10.1300/J092v08n02_04 


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history