Nitric oxide hypothesis

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Nitric oxide hypothesis


Theory[edit]

Dr Martin Pall states: "I propose here a novel hypothesis of CFS in which either viral or bacterial infection induces one or more cytokines, IL-1beta IL-6, TNF-alpha and IFN-gamma. These induce nitric oxide synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with superoxide radical to generate the potent oxidant peroxynitrite. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."[1]

Evidence[edit]

Learn more[edit]

See also[edit]

References[edit]

  1. Pall, ML. (2000). Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. Medical Hypotheses, 54 (1):115-25. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10790736


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history