Hyperalgesia

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Hyperalgesia is an abnormal increase in sensitivity or an amplification of normally painful or uncomfortable stimulus. A person with hyperalgesia experiences an excessive amount of pain compared to the physical severity of damage or illness in their body.[1]

Generalized hyperalgesia is common in fibromyalgia (FMS) and chronic fatigue syndrome (ME/CFS) and some studies indicate it may be partly caused by a mechanism in which microglial accumulation and activation is involved,[2] as well as other possible immune system changes, such as complement system product C4a.[3]

Symptom recognition[edit | edit source]

Hypersensitivity to pain is a sensory symptom recognized in the Canadian Consensus Criteria for Myalgic Encephalomyelitis.[4]

Notable studies[edit | edit source]

  • 2010, Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study[5]
  • 2014, A chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation[2]
  • 2019, Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies[3]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Shaikh, Maliha; Hakim, Alan J; Shenker, Nicholas (2010). "The physiology of pain". Elsevier: 35–52. doi:10.1016/b978-0-7020-3005-5.00003-3. ISBN 9780702030055. 
  2. 2.02.1 Yasui, Masaya; Yoshimura, Takashi; Takeuchi, So; Tokizane, Kyohei; Tsuda, Makoto; Inoue, Kazuhide; Kiyama, Hiroshi (Sep 2014). "A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation: Microglia-Mediated Pain Under Chronic Stress". Glia. 62 (9): 1407–1417. doi:10.1002/glia.22687. PMID 24852223. 
  3. 3.03.1 Polli, Andrea; Van Oosterwijck, Jessica; Meeus, Mira; Lambrecht, Luc; Nijs, Jo; Ickmans, Kelly (Jan 28, 2019). "Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – a secondary analysis of experimental comparative studies". Scandinavian Journal of Pain. 19 (1): 183–192. doi:10.1515/sjpain-2018-0075. ISSN 1877-8879. PMID 30325737. 
  4. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, A C Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7-115, doi:10.1300/J092v11n01_02 
  5. Meeus, Mira; Nijs, Jo; Huybrechts, Sven; Truijen, Steven (Apr 2010). "Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study". Clinical Rheumatology. 29 (4): 393–398. doi:10.1007/s10067-009-1339-0. ISSN 0770-3198. PMID 20077123. 
  6. Dellwo, Adrienne; Hughes, Grant (Aug 7, 2017). "How Does Hyperalgesia Impact Fibromyalgia?". Verywell Health. Retrieved Feb 22, 2019. 

Myalgic encephalomyelitis or chronic fatigue syndrome, often used when both illnesses are considered the same.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.