Allodynia

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Allodynia refers to pain caused by what would normally be non-painful stimulation, for example brushing the skin.[1] Temperature change, light touching, and clothing can trigger the pain response resulting in a burning sensation often occurring after an injury to a site.[2]

Presentation[edit | edit source]

There are three types of allodynia. Tactile, where pain is caused by touches such as clothing touching the skin or someone lightly touching the arm; Mechanical, caused by movement across the skin when drying with a towel or sheets brushing against the skin; and Thermal, which is caused by heat or cold that is not extreme enough to cause damage to skin tissues.[3]

Allodynia in ME/CFS and Fibromyalgia[edit | edit source]

Allodynia is not a diagnostic symptom of ME or CFS, and is not even referred to in the International Consensus Criteria Primer for ME although over forms of pain are.[4]

Prevalence[edit | edit source]

A study of over 3,000 patients with fibromyalgia found that allodynia was "surprisingly common."[5]

Notable studies[edit | edit source]

  • 2009, Models and Mechanisms of Hyperalgesia and Allodynia[1](Full text)
  • 2010, A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles[5](Full text)

Possible causes[edit | edit source]

Central pain sensitization (increased response of neurons) has been proposed as a possible cause, but this term has conflicting definitions and scientific evidence is unclear.[1][2]

Potential treatments[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.