Relationship to ME/CFS[edit | edit source]
Increased C4a levels have been found one to six hours after exercise challenge tests in ME/CFS patients but not in healthy controls. Others found a strong relation between the change in complement C4a level and an increase in post-exertional pain and fatigue in ME/CFS patients. Previously, complement C4a, in combination with other proteins, was being considered as a potential marker of post-exertional malaise in ME/CFS.(Full text)
References[edit | edit source]
- Behairy BE, El-Mashad GM, Abd-Elghany RS, Ghoneim EM, Sira MM.Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C.World J Hepatol. 2013 Aug 27;5(8):445-51.
- Sorensen B, Streib JE, Strand M, Make B, Giclas PC, Fleshner M, Jones JF. Complement activation in a model of chronic fatigue syndrome.J Allergy Clin Immunol. 2003 Aug;112(2):397-403. PMID: 12897748
- Nijs, J.; Van Oosterwijck, J.; Meeus, M.; Lambrecht, L.; Metzger, K.; Frémont, M.; Paul, L. (2010). "Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1β". Journal of Internal Medicine. 267 (4): 418–435. doi:10.1111/j.1365-2796.2009.02178.x. ISSN 1365-2796.
- Sorensen, Bristol; Jones, James F; Vernon, Suzanne D; Rajeevan, Mangalathu S (Jan 2009). "Transcriptional Control of Complement Activation in an Exercise Model of Chronic Fatigue Syndrome". Molecular Medicine. 15 (1-2): 34–42. doi:10.2119/molmed.2008.00098. PMC . PMID 19015737.
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.