Common symptoms in ME/CFS

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
(Redirected from Common symptoms in ME CFS)
Jump to: navigation, search

Common symptoms in ME/CFS include post-exertional malaise, multiple types of fatigue, and a range of neurological, cardiovascular, energy metabolism and endocrine symptoms.[1][2][3][4]

Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) is often referred to as ME/CFS as it is clear there are common onsets and symptoms shared by both the disease ME and the symptoms that define CFS.

Chronic Fatigue Syndrome[edit | edit source]

Common Symptoms in Chronic Fatigue Syndrome

Symptom Mild to Severe
Symptom %
Moderate to Severe
Symptom %
Fatigue - persist or relapsing*
100
95
Significant reduction in activities*
100
100
Symptoms last over 6 months*
100
100
Post-exertional malaise
96
86
Memory & concentration probs
98
80
Unrefreshing sleep
99
92
Headaches - new or different
90
50
Muscle pain (myalgia)
96
73
Sore throat
81
31

Source: Jason et al. 2014

*Required symptom, can be mild


Jason et al. (2014) found these symptoms were the most common among people who met the Fukuda criteria, which are the symptoms normally used to diagnose in the US and UK.


Approximately 60% of people with Chronic Fatigue Syndrome also meet the criteria for M.E.[5]

Symptom Mild to Severe
Symptom
Moderate or Severe
Symptom
Fatigue - persist or relapsing* 100 95
Substantial reduction in activities* 100 100
Symptoms last over 6 months* 100 100
Post-exertional malaise 96 86
Memory & concentration difficulties 98 80
Unrefreshing sleep 99 92
New or different headaches 90 50
Muscle pain (myalgia) 96 73
Sore throat 81 31
Joint pain (arthralgia) 86 65
Lymph node pain 81 44

*Required symptom, can be mild

Myalgic Encephalomyelitis[edit | edit source]

Common Myalgic Encephalomyelitis Symptoms
Symptom  %
50% reduction in previous activity level
100(Required)
Post-exertional neuroimmune exhaustion
100(Required)

Fatigue - moderate or severe
80

Minimum exercise makes you tired
82(PENE)
Next-day soreness after mild activity
79
Physically drained/sick after mild activity
77
Dead, heavy feeling after start of exercise
73
Mentally tired after slightest effort
68

Unrefreshing sleep
82(Neuro)
Difficulty paying attention for long
77
Muscle pain (myalgia)
69

Sensitive to smells/foods/drugs/chemicals
67(Immune / GI / Urinary)
Flu-like symptoms
64
Irritable bowel problems
56

Feeling hot / cold for no reason
58(Ion transport / Metabolism)

Sources: Jason et al. 2016, Intl Consensus Criteria 2011


Myalgic Encephalomyelitis diagnosis requires more symptoms than Chronic Fatigue Syndrome diagnosis.[1]

People with M.E. typically meet the CFS criteria as well, and were found to have more severe symptoms and reduced functioning overall.[5]


Long list of symptoms[edit | edit source]

The Canadian Consensus Criteria lists these as known symptoms in Appendix 4.

Right arrow.png
Cognitive symptoms
Down arrow.png
Cognitive symptoms
Right arrow.png
Motor and balance
Down arrow.png
Motor and balance
Right arrow.png
Sleep disturbances
Down arrow.png
Sleep disturbances


Symptom recognition[edit | edit source]

The DePaul Symptom Questionnaire can be used to assess symptoms of both M.E. and CFS.[5] The Canadian Consensus Criteria (Appendix 4) also contains an extensive list of possible symptoms. [4] The severity of illness and overall health can be assessed using the SF-36 health survey.[5]

Notable studies[edit | edit source]

Castro-Marrero et al. 2017[edit | edit source]

Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study

  • 1757 Spanish subjects who met both the 1994 CDC/Fukuda definition and Canadian Consensus Criteria for CFS/ME. Table 2 gives prevelance of each ME/CFS symptom in the Canadian Consensus Criteria

Jason et al. 2016[edit | edit source]

Are Myalgic Encephalomyelitis and chronic fatigue syndrome different illnesses? A preliminary analysis.

  • Myalgic Encephalomyelitis (International Consensus Criteria) symptoms are compared with symptoms of patients meeting the Chronic Fatigue Syndrome Fukuda criteria but not the M.E. criteria. Those meeting the M.E. criteria were also found to meet the CFS criteria, and to have more severe symptoms.

Jason et. al 2014[edit | edit source]

Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis

  • 236 patients completed the DePaul Symptom Questionnaire, rating the frequency and severity of 54 symptoms, compared to controls.

de Becker et al. 2010[edit | edit source]

A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome

  • A study of 2073 patients complaining of chronic fatigue (CF) in Brussels. Table 1 and Table 2 show the how many patients had each symptom according to whether they met the Fukuda criteria, the Holmes criteria or had chronic fatigue without CFS.

1578 CFS patients fulfilled the Fukuda criteria (called the "CFS group") and 951 (60.3% of the CFS group) fulfilled the Holmes criteria. The Holmes definition was found to be better than the Fukuda at differentiated CFS patients from the patients with Chronic Fatigue without CFS.

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.1 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6 
  2. De Becker, P.; McGregor, N.; De Meirleir, K. (Sep 15, 2001). "A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome". Journal of Internal Medicine. 250 (3): 234–240. doi:10.1046/j.1365-2796.2001.00890.x. ISSN 0954-6820. 
  3. Jason, Leonard A.; Sunnquist, Madison; Brown, Abigail; Evans, Meredyth; Vernon, Suzanne D.; Furst, Jacob; Simonis, Valerie (Jan 1, 2014). "Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis". Fatigue : biomedicine, health & behavior. 2 (1): 40–56. doi:10.1080/21641846.2013.862993. ISSN 2164-1846. PMC 3912876Freely accessible. PMID 24511456. 
  4. 4.04.1 Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip (May 2002). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF). Journal of Chronic Fatigue Syndrome. 11 (1): 7–115. doi:10.1300/j092v11n01_02. ISSN 1057-3321. 
  5. 5.05.15.25.3 Jason, Leonard A; Sunnquist, Madison; Brown, Abigail; Evans, Meredyth; Newton, Julia L (January 2016). "Are Myalgic Encephalomyelitis and chronic fatigue syndrome different illnesses? A preliminary analysis". Journal of health psychology. 21 (1): 3–15. doi:10.1177/1359105313520335. ISSN 1359-1053. PMC 4125561Freely accessible. PMID 24510231. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Fukuda criteria - The most commonly used diagnostic criteria for chronic fatigue syndrome, created by the United States Centers for Disease Control (CDC).

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others.

Myalgia - Muscle pain.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Canadian consensus criteria (CCC) - A set of diagnostic criteria used to diagnose ME/CFS, developed by a group of practicing ME/CFS clinicians in 2003. The CCC is often considered to be the most complex criteria, but possibly the most accurate, with the lowest number of patients meeting the criteria. Led to the development of the International Consensus Criteria (ICC) in 2011.

Chronic fatigue (CF) - Persistent and abnormal fatigue is a symptom, not an illness. It may be caused by depression, multiple sclerosis, fibromyalgia, chronic fatigue syndrome or many other illnesses. The term "chronic fatigue" should never be confused with the disease chronic fatigue syndrome.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.