Pyridoxal-5'-phosphate

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Vitamin B6 (pyridoxal-5'-phosphate, P5P, PLP, pyridoxine, pyridoxamine) is a co-factor in amino acid metabolism, the folate cycle, and the biosynthesis of neurotransmitters, including dopamine, GABA, melatonin, norepinephrine, and serotonin.

Role in the body[edit | edit source]

Vitamin B6 is a cofactor for diamine oxidase, the enzyme that breaks down histamine. It is also a cofactor of histidine decarboxylase, the enzyme that catalyzes the decarboxylation of histidine to form histamine.

Chronic fatigue syndrome[edit | edit source]

One very small study found decreased functional status of several B vitamins including pyridoxine, riboflavin and thiamine.[1]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. Heap, L. C.; Peters, T. J.; Wessely, S. (Apr 1, 1999), "Vitamin B Status in Patients with Chronic Fatigue Syndrome", Journal of the Royal Society of Medicine, 92 (4): 183–185, doi:10.1177/014107689909200405, ISSN 0141-0768, PMID 10450194, retrieved Nov 9, 2016 

cofactor - A substance that acts with another substance to bring about certain effects. In biochemistry, a cofactor is a molecule that is necessary for a given biochemical reaction, but is not an enzyme or substrate of the reaction.

enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.