Jarred Younger
Jarred W. Younger B.A. PhD. is an American researcher who leads the Neuroinflammation, Pain and Fatigue lab at the University of Birmingham, Alabama, United States.[1] He previously worked at the Stanford ME/CFS Initiative with Jose Montoya, as an Assistant Professor involved in a notable study highlighting leptin levels and ME/CFS.[2][3]
He is currently funded by the U.S. National Institutes of Health and Department of Defense to study new techniques for diagnosing and treating neuroinflammation in ME/CFS, fibromyalgia and Gulf War Illness. In particular his work focuses on the role of microglia.
Awards[edit | edit source]
- 2016 Ramsay Award Program grant recipient, sponsored by the Solve ME/CFS Initiative for Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions[4][5]
Committees and boards[edit | edit source]
ME/CFS Collaborative Research Center[edit | edit source]
Dr. Younger is a member of the Working Group which offers their expertise and resources to the ME/CFS Collaborative Research Center at Stanford University.[6]
ME/CFS Common Data Element (CDE) Project[edit | edit source]
Chair (Overall/Cognitive) of the Neurologic/Cognitive/CNS Imaging Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke (NINDS) and the Centers for Disease Control and Prevention (CDC).[7]
Notable studies[edit | edit source]
- 2010, Low dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels[8] - (Full Text)
- 2009, Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study[9] - (Full Text)
- 2013, Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: Evidence of inflammatory pathology[2] - (Full Text)
- 2017, Cytokine signature associated with disease severity in chronic fatigue syndrome patients[10] - (Full Text)
- 2019, Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy[11] - (Abstract)
Talks and interviews[edit | edit source]
- 2011, Chronic Pain in Women
- 2014, ME/CFS Alerts Episode 68: Jarred Younger Interviewed by Deborah Waroff
- 2015, Dr Jarred Younger - LDN Scientist - Low Dose Naltrexone
- 2015, Pandora Research Report: Jarred Younger - Leptin in the Role of Neuroinflammation, Pain and Fatigue (see Leptin)
- 2015, Jarred Younger, Ph.D. - Microglial Modulation in the Treatment of Fibromyalgia
- 2015, Spoonie Radio Ep 15: Jarred Younger (see also Courtney Craig)
- 2016, Chronic Fatigue Syndrome & Myalgic Encephalomyelitis: Can We Find Answers in the Brain? - Solve CFS Webinar
- 2016, Younger Lab YouTube Channel: Series of ongoing talks on the work of the lab
- 2016, Dr. Jarred Younger: Cutting Edge Research on CFS, Neuroinflammation, Pain, and Fatigue
- 2018, ME/CFS Involves Brain Inflammation: Results from a Ramsay Pilot Study[12]
- 29 Sep 2018, How Brain Inflammation Causes ME/CFS, given at Second Annual Community Symposium on the Molecular Basis of ME/CFS, sponsored by Open Medicine Foundation - (Video)
- 2019, Dr. Jarred Younger - Neuroinflammation in ME/CFS
- 2022, Dr. Jarred Younger Presents: How We Can See ME/CFS Inflammation in the Brain - Solve ME Webinar
Articles and blogs[edit | edit source]
- 2015, The Neuroinflammation Man: Jarred Younger on Inflammation, Fibromyalgia and Chronic Fatigue Syndrome (Cort Johnson)
- 2015, New Chronic Fatigue Syndrome and Fibromyalgia Lab Opens: Jarred Younger Talks (Cort Johnson)
- 2016, Prisoners of Pain - UAB magazine (Spring 2016)
- 2016, Self Hacked on Dr Younger
- 2016, Younger Lab YouTube Channel
- 2016, Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS) Research Center Makes Good (Cort Johnson)
- 2018, Brain on Fire: Widespread Neuroinflammation Found in Chronic Fatigue Syndrome (ME/CFS)(Cort Johnson)
Younger's new approach looked at the entire brain and found signs of inflammation almost everywhere. When asked what could cause that, Younger said that any neurodegenerative/ neuroinflammatory disorder like MS or a severe brain injury that tweaks the microglia (immune cells in the brain) enough to produce a sustained period of inflammation, burns up the oxygen in the system. Once that happens, the cells resort to anaerobic metabolism and lactate builds up just as it does in the muscles during exercise.
See also[edit | edit source]
- Fibromyalgia
- Gulf War Illness
- Chronic fatigue syndrome
- Leptin
- Low dose naltrexone
- Microglia
- Neuroinflammation
Learn more[edit | edit source]
- Publications on the PubMed register - Jarred Younger
- UAB Departmental Website
- Biography at UAB
- Facebook page for Younger's Lab at UAB
- YouTube channel for Younger's Lab at UAB
References[edit | edit source]
- ↑ https://www.uab.edu/cas/psychology/people/faculty/jarred-younger
- ↑ 2.0 2.1 Stringer, EA; Baker, KS; Carrol, IR; Montoya, JG; Chu, L; Maeker, HT; Younger, JW (April 9, 2013). "Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: Evidence of inflammatory pathology". J Transl Med. doi:10.1186/1479-5876-11-93. PMC 3637529. PMID 23570606.
- ↑ "Pandora Research Report: Jarred Younger - Leptin in the Role of Neuroinflammation, Pain and Fatigue". January 24, 2015. Retrieved September 12, 2019.
- ↑ "2016 Ramsay Award Program Results". Solve ME/CFS Initiative. Retrieved September 12, 2019.
- ↑ "Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions". Solve ME/CFS Initiative. December 7, 2016. Retrieved February 18, 2020.
- ↑ "OMF grants $1.2M to Ramp Up Collaborative Research Center at Stanford University". bos.etapestry.com. Retrieved September 12, 2019.
- ↑ "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved October 11, 2019.
- ↑ Younger, Jarred; Noor, Noorulain; McCue, Rebecca; Mackey, Sean (February 2013). "Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels". Arthritis & Rheumatism. 65 (2): 529–538. doi:10.1002/art.37734.
- ↑ Younger, Jarred; Mackey, Sean (May 2009). "Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study". Pain Medicine. 10 (4): 663–672. doi:10.1111/j.1526-4637.2009.00613.x. ISSN 1526-2375. PMC 2891387. PMID 19453963.
- ↑ Montoya, Jose G.; Holmes, Tyson H.; Anderson, Jill N.; Maecker, Holden T.; Rosenberg-Hasson, Yael; Valencia, Ian J.; Chu, Lily; Younger, Jarred W.; Tato, Cristina M.; Davis, Mark M. (2017). "Cytokine signature associated with disease severity in chronic fatigue syndrome patients". Proceedings of the National Academy of Sciences of the United States of America. 114 (34): E7150-E7158. doi:10.1073/pnas.1710519114.
- ↑ Mueller, Christina; Lin, Joanne C.; Sheriff, Sulaiman; Maudsley, Andrew A.; Younger, Jarred W. (January 7, 2019). "Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy". Brain Imaging and Behavior. doi:10.1007/s11682-018-0029-4. ISSN 1931-7557.
- ↑ "ME/CFS Involves Brain Inflammation: Results from a Ramsay Pilot Study". YouTube. SolveCFS. December 14, 2018.
