From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
A computer graphic drawing of leptin.

Leptin is a hormone involved in energy expenditure. Blood leptin levels vary exponentially with body fat mass (not linearly). Higher leptin levels are correlated with higher levels of inflammation.

Purpose[edit | edit source]

Leptin is primarily produced in the adipocytes of white adipose (fat) tissue. It helps to regulate energy balance by inhibiting feelings of hunger.

In M.E.[edit | edit source]

Two studies found correlation between leptin levels and symptom severity.[1][2] Another study found raised leptin levels in patients.[3] Several other studies have been published on leptin in ME and CFS.[4][5][6]

Australian researcher Michael Musker is undertaking a study entitled "Chronic fatigue syndrome: Leptin, interleukin 6 and clinical symptoms".[7][8]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. Stringer, EA; Baker, KS; Carroll, IR; Montoya, JG; Chu, L; Maecker, HT; Younger, JW (2013), "Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology", Journal of Translational Medicine, 11 (1): 93, doi:10.1186/1479-5876-11-93, PMID 23570606
  2. Montoya, JG; Holmes, TH; Anderson, JN; Maecker, HT; Rosenberg-Hasson, Y; Valencia, IJ; Chu, L; Younger, JW; Tato, CM; Davis, MM (2017), "Cytokine signature associated with disease severity in chronic fatigue syndrome patients", Proceedings of the National Academy of Sciences of the United States of America, 114 (34): E7150–E7158, doi:10.1073/pnas.1710519114, PMID 28760971
  3. Hornig, M; Montoya, JG; Klimas, NG; Levine, SM; Felsenstein, D; Bateman, L; Peterson, DL; Gottschalk, CG; Schultz, AF; Che, X; Eddy, ML; Komaroff, AL; Lipkin, WI (2015). "Distinct plasma immune signatures in ME/CFS are present early in the course of illness". Science Advances. 1 (1). doi:10.1126/sciadv.1400121.
  4. Cleare, Anthony J; O'Keane, V; Miell, J (2001), "Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion", Clinical Endocrinology, 55 (1): 113-119, PMID 11453960
  5. Cleare, Anthony J (2003), "The neuroendocrinology of chronic fatigue syndrome", Endocrine Reviews, 24 (2): 236-252, doi:10.1210/er.2002-0014, PMID 12700181
  6. Covelli, V; Passeri, ME; Leogrande, D; Jirillo, E; Amati, L (2005), "Drug targets in stress-related disorders", Current Medicinal Chemistry, 12 (15): 1801–1809, PMID 16029148
  7. South Australian Health And Medical Research Institute (SAHMRI) Calling For Research Participants
  8. Musker, Michael; McArthur, Alexa; Munn, Zachary; Wong, Ma-Li (November 2, 2020). "Circulating leptin levels in patients with myalgic encephalomyelitis, chronic fatigue syndrome or fibromyalgia: a systematic review protocol". JBI Evidence Synthesis. 19 (3): 695–701. doi:10.11124/JBIES-20-00125. ISSN 2689-8381.