Leptin

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A computer graphic drawing of leptin.
Leptin

Leptin is a hormone involved in energy expenditure. Blood leptin levels vary exponentially with body fat mass (not linearly). Higher leptin levels are correlated with higher levels of inflammation.

Purpose[edit | edit source]

Leptin is primarily produced in the adipocytes of white adipose (fat) tissue. It helps to regulate energy balance by inhibiting feelings of hunger.

In M.E.[edit | edit source]

Two studies found correlation between leptin levels and symptom severity.[1][2] Another study found raised leptin levels in patients.[3] Several other studies have been published on leptin in ME and CFS.[4][5][6]

Australian researcher Michael Musker is undertaking a study entitled "Chronic fatigue syndrome: Leptin, interleukin 6 and clinical symptoms".[7]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. Stringer, EA; Baker, KS; Carroll, IR; Montoya, JG; Chu, L; Maecker, HT; Younger, JW (2013), "Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology", Journal of Translational Medicine, doi:10.1186/1479-5876-11-93, PMID 23570606 
  2. Montoya, JG; Holmes, TH; Anderson, JN; Maecker, HT; Rosenberg-Hasson, Y; Valencia, IJ; Chu, L; Younger, JW; Tato, CM; Davis, MM (2017), "Cytokine signature associated with disease severity in chronic fatigue syndrome patients", Proceedings of the National Academy of Sciences of the United States of America, doi:10.1073/pnas.1710519114, PMID 28760971 
  3. Hornig, M; Montoya, JG; Klimas, NG; Levine, SM; Felsenstein, D; Bateman, L; Peterson, DL; Gottschalk, CG; Schultz, AF; Che, X; Eddy, ML; Komaroff, AL; Lipkin, WI (2015), "Distinct plasma immune signatures in ME/CFS are present early in the course of illness", Science Advances, 1 (1), doi:10.1126/sciadv.1400121 
  4. Cleare, Anthony J; O'Keane, V; Miell, J (2001), "Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion", Clinical Endocrinology, 55 (1): 113-119, PMID 11453960 
  5. Cleare, Anthony J (2003), "The neuroendocrinology of chronic fatigue syndrome", Endocrine Reviews, 24 (2): 236-252, doi:10.1210/er.2002-0014, PMID 12700181 
  6. Covelli, V; Passeri, ME; Leogrande, D; Jirillo, E; Amati, L (2005), "Drug targets in stress-related disorders", Current Medicinal Chemistry, 12 (15): 1801 - 1809, PMID 16029148 
  7. South Australian Health And Medical Research Institute (SAHMRI) Calling For Research Participants

Myalgic encephalomyelitis or M.E. has different diagnostic criteria to chronic fatigue syndrome; neurological symptoms are required but fatigue is an optional symptom.<ref name="ICP2011primer">{{Citation

Myalgic encephalomyelitis or chronic fatigue syndrome


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history