Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder - New York Times: Well (2014)
Plainly seen is the result of neuroinflammation's impact on the brain.
Brain imaging studies mentioned in article[edit | edit source]
- 2014, The Stanford ME/CFS Initiative, directed by Dr. Jose Montoya and working with Dr. Michael Zeineh and colleagues, studied the brains of patients with chronic fatigue syndrome (CFS) and healthy people and found distinct differences between the two groups. Radiology researchers have discovered that the brains of patients with CFS have diminished white matter and white matter abnormalities in the right hemisphere.
- 2014, A Japanese PET study looked at neuroinflammation in 9 patients with ME/CFS and 10 controls. They measured a protein expressed by activated microglia, and found that values in the cingulate cortex, hippocampus, amygdala, thalamus, midbrain, and pons were 45%–199% higher in ME/CFS patients than in healthy controls. The values in the amygdala, thalamus, and midbrain positively correlated with cognitive impairment score, the values in the cingulate cortex and thalamus positively correlated with pain score, and the value in the hippocampus positively correlated with depression score.
Myalgic encephalomyelitis[edit | edit source]
Myalgic encephalomyelitis (ME) was the original name for chronic fatigue syndrome (CFS); the names are used interchangeably or with the acronym ME/CFS. The name ME was coined by Dr. Melvin Ramsay following the 1955 Royal Free Hospital outbreak and is a portmanteau of several of the key signs and symptoms of the disease: myalgic (muscle pain), encephalo (brain), myel (spinal cord), itis (inflammation). The central nervous system (brain and spinal cord) are inflamed.
Criterion defining ME, CFS, and ME/CFS[edit | edit source]
Patients that meet the International Consensus Criteria (ICC) defining ME are usually more severely impaired than patients that meet the Canadian Consensus Criteria (CCC) defining ME/CFS, or the minimum core symptoms needed to diagnose patients with Systemic Exertion Intolerance Disease (SEID); also an ME/CFS criterion. Researchers believe all patients meeting these criterion, including Fukuda criteria (with post-exertional malaise "option") defining CFS, are experiencing brain inflammation.
See also[edit | edit source]
Learn More[edit | edit source]
References[edit | edit source]
- Tuller, David (Nov 14, 2014). "Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder". The New York Times - Well. Retrieved Nov 28, 2018.
- Zeineh, Michael M; Kang, James; Atlas, Scott W; et al. (Oct 29, 2014), "Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome", Radiology, 274 (2): 517–526, doi:10.1148/radiol.14141079
- Goldman, Bruce (Oct 28, 2014), "Study finds brain abnormalities in chronic fatigue patients", Stanford Medicine News Center
- Tuller, David (Nov 24, 2014), "Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder", NY Times
- Nakatomi, Yasuhito; Mizuno, Kei; Ishii, Akira; et al. (Mar 24, 2014), "Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study", Journal of Nuclear Medicine, 2014 Jun;55(6): 945-50, doi:10.2967/jnumed.113.131045, PMID 24665088
- Dellwo, Adrienne (Nov 24, 2018). "Myalgic Encephalomyelitis or Chronic Fatigue Syndrome". Verywell Health. Retrieved Nov 28, 2018.
- Dellwo, Adrienne (Jul 23, 2018). "Myalgic Encephalomyelitis: Chronic Fatigue Syndrome's Other Name". Verywell Health. Retrieved Aug 12, 2018.
- "An Outbreak of Encephalomyelitis in the Royal Free Hospital Group, London, in 1955". British Medical Journal. 2 (5050): 895–904. Oct 19, 1957. ISSN 0007-1447. PMID 13472002.
- The Terminology of ME & CFS By Professor Malcolm Hooper
- "myalgic". TheFreeDictionary.com. Retrieved Aug 12, 2018.
- "encephalo-". TheFreeDictionary.com. Retrieved Aug 12, 2018.
- "myel-". TheFreeDictionary.com. Retrieved Aug 12, 2018.
- "Itis". TheFreeDictionary.com. Retrieved Aug 12, 2018.
Myalgic encephalomyelitis or chronic fatigue syndrome