Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder - New York Times: Well (2014)
Plainly seen is the result of neuroinflammation's impact on the brain.
Brain imaging studies mentioned in article[edit | edit source]
- 2014, The Stanford ME/CFS Initiative, directed by Dr. Jose Montoya and working with Dr. Michael Zeineh and colleagues, studied the brains of patients with chronic fatigue syndrome (CFS) and healthy people and found distinct differences between the two groups. Radiology researchers have discovered that the brains of patients with CFS have diminished white matter and white matter abnormalities in the right hemisphere.
- 2014, A Japanese PET scan study looked at neuroinflammation in 9 patients with ME/CFS and 10 controls. They measured a protein expressed by activated microglia, and found that values in the cingulate cortex, hippocampus, amygdala, thalamus, midbrain, and pons were 45%–199% higher in ME/CFS patients than in healthy controls. The values in the amygdala, thalamus, and midbrain positively correlated with cognitive impairment score, the values in the cingulate cortex and thalamus positively correlated with pain score, and the value in the hippocampus positively correlated with depression score.
Myalgic encephalomyelitis[edit | edit source]
Myalgic encephalomyelitis (ME) was the original name for chronic fatigue syndrome (CFS); the names are used interchangeably or with the acronym ME/CFS. The name ME was coined by Dr. Melvin Ramsay following the 1955 Royal Free Hospital outbreak and is a portmanteau of several of the key signs and symptoms of the disease: myalgic (muscle pain), encephalo (brain), myel (spinal cord), itis (inflammation). The central nervous system (brain and spinal cord) are inflamed.
Criterion defining ME, CFS, and ME/CFS[edit | edit source]
Patients that meet the International Consensus Criteria (ICC) defining ME are usually more severely impaired than patients that meet the Canadian Consensus Criteria (CCC) defining ME/CFS, or the minimum core symptoms needed to diagnose patients with Systemic Exertion Intolerance Disease (SEID); also an ME/CFS criterion. Researchers believe all patients meeting these criterion, including Fukuda criteria (with post-exertional malaise "option") defining CFS, are experiencing brain inflammation.
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- Tuller, David (November 14, 2014). "Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder". The New York Times - Well. Retrieved November 28, 2018.
- Zeineh, Michael M.; Kang, James; Atlas, Scott W.; Raman, Mira M.; Reiss, Allan L.; Norris, Jane L.; Valencia, Ian; Montoya, Jose G. (February 2015). "Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome". Radiology. 274 (2): 517–526. doi:10.1148/radiol.14141079. ISSN 0033-8419.
- Goldman, Bruce (October 28, 2014). "Study finds brain abnormalities in chronic fatigue patients". Standford University News Center. Retrieved January 10, 2020.
- Tuller, David (November 24, 2014), "Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder", NY Times
- Nakatomi, Yasuhito; Mizuno, Kei; Ishii, Akira; et al. (March 24, 2014), "Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study", Journal of Nuclear Medicine, 55 (6): 945-50, doi:10.2967/jnumed.113.131045, PMID 24665088
- Dellwo, Adrienne (November 24, 2018). "Myalgic Encephalomyelitis or Chronic Fatigue Syndrome". Verywell Health. Retrieved November 28, 2018.
- Dellwo, Adrienne (July 23, 2018). "Myalgic Encephalomyelitis: Chronic Fatigue Syndrome's Other Name". Verywell Health. Retrieved August 12, 2018.
- "An Outbreak of Encephalomyelitis in the Royal Free Hospital Group, London, in 1955". British Medical Journal. 2 (5050): 895–904. October 19, 1957. ISSN 0007-1447. PMID 13472002.
- The Terminology of ME & CFS By Professor Malcolm Hooper
- "myalgic". TheFreeDictionary.com. Retrieved August 12, 2018.
- "encephalo-". TheFreeDictionary.com. Retrieved August 12, 2018.
- "myel-". TheFreeDictionary.com. Retrieved August 12, 2018.
- "Itis". TheFreeDictionary.com. Retrieved August 12, 2018.
- Morris, Gerwyn; Maes, Michael (December 2013). "Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics". BMC Medicine. 11 (1): 205. doi:10.1186/1741-7015-11-205. ISSN 1741-7015. PMC 3847236. PMID 24229326.
- Nakatomi, Y.; Mizuno, K.; Ishii, A.; Wada, Y.; Tanaka, M.; Tazawa, S.; Onoe, K.; Fukuda, S.; Kawabe, J.; Takahashi, Kazuhiro; Kataoka, Yosky; Shiomi, Susumu; Yamaguti, Kouzi; Masaaki, Inaba; Kuratsune, Hirohiko; Watanabe, Yasuyoshi (June 1, 2014). "Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study". Journal of Nuclear Medicine. 55 (6): 945–950. doi:10.2967/jnumed.113.131045. ISSN 0161-5505.
amygdala Part of the brain, within the temporal lobe. Related to memory and emotional behavior.
myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.
Canadian Consensus Criteria (CCC) - A set of diagnostic criteria used to diagnose ME/CFS, developed by a group of practicing ME/CFS clinicians in 2003. The CCC is often considered to be the most complex criteria, but possibly the most accurate, with the lowest number of patients meeting the criteria. Led to the development of the International Consensus Criteria (ICC) in 2011.
systemic exertion intolerance disease (SEID) - A term for ME/CFS that aims to avoid the stigma associated with the term "chronic fatigue syndrome", while emphasizing the defining characteristic of post-exertional malaise (PEM). SEID was defined as part of the diagnostic criteria put together by the Institute of Medicine (IOM) report of 10 February 2015.