Kynurenine: Difference between revisions
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* [[Kynurenine pathway hypothesis]] | * [[Kynurenine pathway hypothesis]] | ||
*[[Metabolic trap]] | *[[Metabolic trap]] | ||
* [[IDO]] | * [[Indoleamine-2,3-dioxygenase| IDO]] | ||
*[[IDO2]] | *[[Indoleamine-2,3-dioxygenase 2|IDO2]] | ||
* [[Tryptophan]] | * [[Tryptophan]] | ||
Revision as of 17:24, May 1, 2020
 | This article is a stub. |
Kynurenine is an amino acid that is produced in the body by the metabolism of the essential amino acid tryptophan.[1][2]
ME/CFS[edit | edit source]
The Open Medicine Foundation's ME/CFS Severely Ill, Big Data Study found that patients in the study group with severe ME had one of several defects involving the IDO2 gene, which affected tryptophan - kynurenine metabolism.[3] This lead to the Metabolic Trap theory.[3]
In May 2020, the Open Medicine Foundation announced a pilot treatment trial of kynurenine for ME/CFS.[4]
Learn more[edit | edit source]
- Kynurenine - PubChem
- L-Kynurenine - PubChem
See also[edit | edit source]
References[edit | edit source]
- ↑ "Medical Definition of KYNURENINE". www.merriam-webster.com. Retrieved November 30, 2019.
- ↑ National Center for Biotechnology Information. "Kynurenine". PubChem Database. Retrieved January 19, 2020. Cite has empty unknown parameter:
|dead-url=(help) - ↑ 3.0 3.1 Phair, Robert D.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.
- ↑ Open Medicine Foundation. "#May Momentum 2020". Open Medicine Foundation. Retrieved May 1, 2020. Cite has empty unknown parameter:
|dead-url=(help)
