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[[File:Karl Morten.png|200px|thumb|right|Source:obs-gyn.ox.ac.uk]]
[[File:Karl Morten.png|200px|thumb|right|Source:obs-gyn.ox.ac.uk]]
'''Karl J. Morten''', PhD, is a senior researcher and laboratory manager at the Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University, [[United Kingdom]].<ref>{{Cite web|url=https://www.wrh.ox.ac.uk/team/karl-morten|title=Karl Morten — Nuffield Department of Women's & Reproductive Health|last=|first=|authorlink=|last2=|first2=|authorlink2=|date=|website=www.wrh.ox.ac.uk|archive-url=|archive-date=|url-status=|access-date=2020-09-27}}</ref> His work focuses on understanding the role  of [[Mitochondrion|mitochondria]] in health and disease. Some of his work has been funded by [[The ME Association]].<ref>{{cite web|url=http://www.meassociation.org.uk/2016/05/me-associations-contributions-towards-mitochondrial-muscle-research-in-mecfs-17-may-2016/|date=2016-05-17|title=ME Association: contributions towards mitochondrial muscle research|website=[[The ME Association]]}}</ref>
'''Karl J. Morten''', PhD, is a senior researcher and laboratory manager at the Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University, [[United Kingdom]].<ref>{{Cite web | url = https://www.wrh.ox.ac.uk/team/karl-morten | title = Karl Morten — Nuffield Department of Women's & Reproductive Health | last = | first = | authorlink = | date = | website = wrh.ox.ac.uk|archive-url=|archive-date=|url-status=|access-date=2020-09-27}}</ref> His work focuses on understanding the role  of [[Mitochondrion|mitochondria]] in health and disease. Some of his work has been funded by [[The ME Association]].<ref>{{cite web | url = http://www.meassociation.org.uk/2016/05/me-associations-contributions-towards-mitochondrial-muscle-research-in-mecfs-17-may-2016/ | date = 2016-05-17 | title = ME Association: contributions towards mitochondrial muscle research|website=[[The ME Association]]}}</ref>


==Projects funded by ME Association==
==Projects funded by ME Association==


===Mitochondrial function in Neutrophils and Monocytes===
===Mitochondrial function in Neutrophils and Monocytes===
In March 2016 [[The ME Association]] announced it would fund Dr Morten and Professor Joanna Poulton to to assess mitochondrial function in [[Neutrophil]] and [[Monocyte cells]] from ME/CFS patients.<ref>{{Cite web|url=https://www.meassociation.org.uk/2016/03/me-association-to-fund-fourth-study-into-the-role-of-the-mitochondria-in-mecfs-10-march-2016/|title=ME Association to fund fourth study into the role of the mitochondria in ME/CFS {{!}} 10 March 2016|language=en-GB|access-date=2019-08-16}}</ref>  
In March 2016 [[The ME Association]] announced it would fund Dr Morten and Professor Joanna Poulton to to assess mitochondrial function in [[Neutrophil]] and [[Monocyte cells]] from ME/CFS patients.<ref>{{Cite web | url = https://www.meassociation.org.uk/2016/03/me-association-to-fund-fourth-study-into-the-role-of-the-mitochondria-in-mecfs-10-march-2016/ | title = ME Association to fund fourth study into the role of the mitochondria in ME/CFS {{!}} 10 March 2016|language=en-GB|access-date=2019-08-16}}</ref>  


<blockquote>"The pilot study will set up the tests required to assess mitochondrial function in blood samples from ME/CFS patients. This will make the blood tests more globally accessible to a wide range of researchers allowing a more universal validation of the findings of Booth/Myhill."<ref>{{Cite journal|last=Myhill|first=Sarah|author-link=Sarah Myhill|last2=Booth|first2=Norman E.|author-link2=Norman Booth|last3=McLaren-Howard|first3=John|author-link3=John McLaren-Howard|author-link4=|author-link5=|author-link6=|date=2009-01-15|title=Chronic fatigue syndrome and mitochondrial dysfunction|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/|journal=International Journal of Clinical and Experimental Medicine|volume=2|issue=1|pages=1–16|issn=1940-5901|pmc=2680051|pmid=19436827|quote=|via=}}</ref></blockquote>
<blockquote>"The pilot study will set up the tests required to assess mitochondrial function in blood samples from ME/CFS patients. This will make the blood tests more globally accessible to a wide range of researchers allowing a more universal validation of the findings of Booth/Myhill."<ref>{{Cite journal | last = Myhill | first = Sarah | authorlink = Sarah Myhill | last2 = Booth | first2 = Norman E. | authorlink2 = Norman Booth | last3 = McLaren-Howard | first3 = John | authorlink3 = John McLaren-Howarddate=2009-01-15 | title = Chronic fatigue syndrome and mitochondrial dysfunction | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/|journal=International Journal of Clinical and Experimental Medicine|volume=2|issue=1|pages=1–16|issn=1940-5901|pmc=2680051|pmid=19436827|quote=|via=}}</ref></blockquote>


===ME Association Christmas Appeal 2016===
===ME Association Christmas Appeal 2016===
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===Mitochondrial Energy Score test validation study ===
===Mitochondrial Energy Score test validation study ===
In 2019, Karl Morten and colleagues published their attempt to replicate the Mitochondrial Energy Score test provided by Dr [[Sarah Myhill]], [[Norman Booth]] and [[John McLaren-Howard]] using samples from 10 patients who met the Canadian Consensus Criteria fire ME/CFS, and 13 healthy controls.<ref name="Morten2019" /> They were unable to confirm the [[Mitochondrion|mitochondrial]] findings. Myhill responded to the publication, outlining significant factors that may have affected the results including the freezing of samples, and criticized the publication for incorrectly stating that the Mitochondrial Energy Score had been described as a diagnostic test for [[CFS/ME]].<ref name="Myhill2019">{{Cite web|url=https://www.drmyhill.co.uk/wiki/Response_to_the_paper_%27Assessing_cellular_energy_dysfunction_in_CFS/ME_using_a_commercially_available_laboratory_test%27_by_Cara_Tomas_et_al|title=Response to the paper 'Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test' by Cara Tomas et al|last=Myhill|first=Sarah|authorlink=Sarah Myhill|last2=|first2=|authorlink2=|date=Aug 2019|website=www.drmyhill.co.uk|archive-url=|archive-date=|url-status=|access-date=2019-08-16}}</ref>
In 2019, Karl Morten and colleagues published their attempt to replicate the Mitochondrial Energy Score test provided by Dr [[Sarah Myhill]], [[Norman Booth]] and [[John McLaren-Howard]] using samples from 10 patients who met the Canadian Consensus Criteria fire ME/CFS, and 13 healthy controls.<ref name="Morten2019" /> They were unable to confirm the [[Mitochondrion|mitochondrial]] findings. Myhill responded to the publication, outlining significant factors that may have affected the results including the freezing of samples, and criticized the publication for incorrectly stating that the Mitochondrial Energy Score had been described as a diagnostic test for [[CFS/ME]].<ref name="Myhill2019">{{Cite web | url = https://www.drmyhill.co.uk/wiki/Response_to_the_paper_%27Assessing_cellular_energy_dysfunction_in_CFS/ME_using_a_commercially_available_laboratory_test%27_by_Cara_Tomas_et_al | title = Response to the paper 'Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test' by Cara Tomas et al | last = Myhill | first = Sarah | authorlink = Sarah Myhill | date = Aug 2019 | website = drmyhill.co.uk|archive-url=|archive-date=|url-status=|access-date=2019-08-16}}</ref>


== Notable studies ==
== Notable studies ==
* 2019, Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test<ref name="Morten2019">{{Cite journal|last=Morten|first=Karl J.|author-link=Karl Morten|last2=Newton|first2=Julia L.|author-link2=Julia Newton|last3=Joanna L. Elson|author-link3=Joanna Elson|last4=Potter|first4=Michelle|author-link4=Michelle Potter|last5=Lodge|first5=Tiffany A.|author-link5=Tiffany Lodge|last6=Tomas|first6=Cara|author-link6=Cara Tomas|date=2019-08-07|title=Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test|url=https://www.nature.com/articles/s41598-019-47966-z|journal=Scientific Reports|language=en|volume=9|issue=1|pages=1–9|doi=10.1038/s41598-019-47966-z|issn=2045-2322|quote=|via=}}</ref> [https://www.nature.com/articles/s41598-019-47966-z (Full text)]
* 2019, Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test<ref name="Morten2019">{{Cite journal | last = Morten | first = Karl J. | authorlink = Karl Morten | last2 = Newton | first2 = Julia L. | authorlink2 = Julia Newton | last3 = Joanna L. Elson | authorlink3 = Joanna Elson | last4 = Potter | first4 = Michelle | authorlink4 = Michelle Potter | last5 = Lodge | first5 = Tiffany A. | authorlink5 = Tiffany Lodge | last6 = Tomas | first6 = Cara | authorlink6 = Cara Tomas | date = 2019-08-07 | title = Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test | url = https://www.nature.com/articles/s41598-019-47966-z|journal=Scientific Reports|language=en|volume=9|issue=1|pages=1–9|doi=10.1038/s41598-019-47966-z|issn=2045-2322|quote=|via=}}</ref> [https://www.nature.com/articles/s41598-019-47966-z (Full text)]
* 2018, A new approach to find [[Diagnostic biomarker|biomarkers]] in [[ME/CFS|chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)]] by single-cell Raman micro-spectroscopy<ref>{{Cite journal|last=Xu|first=Jiabao|last2=Potter|first2=Michelle|last3=Tomas|first3=Cara|author-link3=Cara Tomas|last4=Elson|first4=Jo|last5=Morten|first5=Karl|author-link5=Karl Morten|last6=Poulton|first6=Joanna|last7=Wang|first7=Ning|last8=Jin|first8=Hanqing|last9=Hou|first9=Zhaoxu|date=2018|title=A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy|url=https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/unauth#!divRelatedContent&articles|journal=The Analyst|language=en|volume=|pages=|doi=10.1039/C8AN01437J|issn=0003-2654|via=}}</ref> [https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/unauth#!divRelatedContent&articles (Abstract)]
* 2018, A new approach to find [[Diagnostic biomarker|biomarkers]] in [[ME/CFS|chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)]] by single-cell Raman micro-spectroscopy<ref>{{Cite journal | last = Xu | first = Jiabao | last2 = Potter | first2 = Michelle | last3 = Tomas | first3 = Cara | authorlink3 = Cara Tomas | last4 = Elson | first4 = Jo | last5 = Morten | first5 = Karl | authorlink5 = Karl Morten | last6 = Poulton | first6 = Joanna | last7 = Wang | first7 = Ning | last8 = Jin | first8 = Hanqing | last9 = Hou | first9 = Zhaoxu | date = 2018 | title = A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy | url = https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/unauth#!divRelatedContent&articles|journal=The Analyst|language=en|volume=|pages=|doi=10.1039/C8AN01437J|issn=0003-2654|via=}}</ref> [https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/unauth#!divRelatedContent&articles (Abstract)]
* 2018, Potential clinical usefulness of gut [[microbiome]] testing in a variety of clinical conditions<ref>{{Cite journal|last=Morten|first=Karl J.|author-link=Karl Morten|last2=Staines-Urias|first2=Eleonora|author-link2=|last3=Kenyon|first3=Julian|author-link3=|author-link4=|author-link5=|date=Dec 2018|title=Potential clinical usefulness of gut microbiome testing in a variety of clinical conditions|url=https://linkinghub.elsevier.com/retrieve/pii/S2452231718300241|journal=Human Microbiome Journal|volume=10|issue=|pages=6–10|doi=10.1016/j.humic.2018.08.003|issn=2452-2317|quote=|via=}}</ref> [https://www.sciencedirect.com/science/article/pii/S2452231718300241 (Full text)]
* 2018, Potential clinical usefulness of gut [[microbiome]] testing in a variety of clinical conditions<ref>{{Cite journal | last = Morten | first = Karl J. | authorlink = Karl Morten | last2 = Staines-Urias | first2 = Eleonora | authorlink2 = | last3 = Kenyon | first3 = Julian | date = Dec 2018 | title = Potential clinical usefulness of gut microbiome testing in a variety of clinical conditions | url = https://linkinghub.elsevier.com/retrieve/pii/S2452231718300241|journal=Human Microbiome Journal|volume=10|issue= | pages = 6–10|doi=10.1016/j.humic.2018.08.003|issn=2452-2317|quote=|via=}}</ref> [https://www.sciencedirect.com/science/article/pii/S2452231718300241 (Full text)]
* 2021, Relationship between cardiopulmonary, mitochondrial and autonomic nervous system function improvement after an individualised activity programme upon Chronic Fatigue Syndrome patients<ref>{{Cite journal|last=Kujawski|first=Sławomir|author-link=|last2=Cossington|first2=Jo|author-link2=|last3=Słomko|first3=Joanna|author-link3=|last4=Zawadka-Kunikowska|first4=Monika|author-link4=|last5=Tafil-Klawe|first5=Małgorzata|author-link5=|last6=Klawe|first6=Jacek|author-link6=|last7=Buszko|first7=Katarzyna|last8=Jakovljevic|first8=Djordje|last9=Kozakiewicz|first9=Mariusz|last10=Morten|first10=Karl J.|author-link10=Karl Morten|last11=Dawes|first11=Helen
* 2021, Relationship between cardiopulmonary, mitochondrial and autonomic nervous system function improvement after an individualised activity programme upon Chronic Fatigue Syndrome patients<ref>{{Cite journal | last = Kujawski | first = Sławomir | authorlink = | last2 = Cossington | first2 = Jo | authorlink2 = | last3 = Słomko | first3 = Joanna | authorlink3 = | last4 = Zawadka-Kunikowska | first4 = Monika | authorlink4 = | last5 = Tafil-Klawe | first5 = Małgorzata | authorlink5 = | last6 = Klawe | first6 = Jacek | authorlink6 = | last7 = Buszko | first7 = Katarzyna | last8 = Jakovljevic | first8 = Djordje | last9 = Kozakiewicz | first9 = Mariusz | last10 = Morten | first10 = Karl J. | authorlink10 = Karl Morten | last11 = Dawes | first11 = Helen | author-link11 = | last12 = Strong | first12 = James W.L. | author-link12 = | last13 = Murovska | first13 = Modra | author-link13 = Modra Murovska | last14 = Van Oosterwijck | first14 = Jessica | author-link14 = Jessica Van Oosterwijck | last15 = Estevez-Lopez | first15 = Fernando | author-link15 = | last16 = Newton | first16 = Julia L. | authorlink16 = Julia Newton | last17 = Hodges | first17 = Lynette | author-link17 = Lynette Hodges | last18 = Zalewski | first18 = Paweł | author-link18 = Paweł Zalewski | last19 = European Network on ME/CFS | first19 = (EUROMENE) | author-link19 = EUROMENE | date = 2021-04-06 | title = Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients | url = https://www.mdpi.com/2077-0383/10/7/1542|journal=Journal of Clinical Medicine|language=en|volume=10|issue=7|pages=1542|doi=10.3390/jcm10071542|issn=2077-0383|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.mdpi.com/2077-0383/10/7/1542/htm (Full text)]
|author-link11=|last12=Strong|first12=James W. L.
|author-link12=|last13=Murovska|first13=Modra|author-link13=Modra Murovska|last14=Van Oosterwijck|first14=Jessica|author-link14=Jessica Van Oosterwijck|last15=Estevez-Lopez|first15=Fernando|author-link15=
|last16=Newton|first16=Julia L.|author-link16=Julia Newton|last17=Hodges|first17=Lynette|last18=Zalewski|first18=Paweł|last19=European Network on ME/CFS|first19=(EUROMENE)
|date=2021-04-06|title=Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients|url=https://www.mdpi.com/2077-0383/10/7/1542|journal=Journal of Clinical Medicine|language=en|volume=10|issue=7|pages=1542|doi=10.3390/jcm10071542|issn=2077-0383|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.mdpi.com/2077-0383/10/7/1542/htm (Full text)]


==Talks and interviews==
==Talks and interviews==

Latest revision as of 13:46, July 25, 2023

Source:obs-gyn.ox.ac.uk

Karl J. Morten, PhD, is a senior researcher and laboratory manager at the Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University, United Kingdom.[1] His work focuses on understanding the role of mitochondria in health and disease. Some of his work has been funded by The ME Association.[2]

Projects funded by ME Association[edit | edit source]

Mitochondrial function in Neutrophils and Monocytes[edit | edit source]

In March 2016 The ME Association announced it would fund Dr Morten and Professor Joanna Poulton to to assess mitochondrial function in Neutrophil and Monocyte cells from ME/CFS patients.[3]

"The pilot study will set up the tests required to assess mitochondrial function in blood samples from ME/CFS patients. This will make the blood tests more globally accessible to a wide range of researchers allowing a more universal validation of the findings of Booth/Myhill."[4]

ME Association Christmas Appeal 2016[edit | edit source]

The ME Association Christmas Appeal for 2016 sought to raise £50,000 to fund research by a team led by Dr Morten to study metabolomics in patients.[5] Dr Morten will work alongside scientists from Oxford and Newcastle Universities including Prof Julia Newton. Part of the team is ME/CFS patient Jamie Strong. [6]

The research will focus on the chemical clues left behind by mitochondrial cells and follow on from the work of Dr Robert Naviaux in this area.[7] 300 blood samples will analysed, many from the UK ME/CFS biobank.

Mitochondrial Energy Score test validation study[edit | edit source]

In 2019, Karl Morten and colleagues published their attempt to replicate the Mitochondrial Energy Score test provided by Dr Sarah Myhill, Norman Booth and John McLaren-Howard using samples from 10 patients who met the Canadian Consensus Criteria fire ME/CFS, and 13 healthy controls.[8] They were unable to confirm the mitochondrial findings. Myhill responded to the publication, outlining significant factors that may have affected the results including the freezing of samples, and criticized the publication for incorrectly stating that the Mitochondrial Energy Score had been described as a diagnostic test for CFS/ME.[9]

Notable studies[edit | edit source]

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ "Karl Morten — Nuffield Department of Women's & Reproductive Health". wrh.ox.ac.uk. Retrieved September 27, 2020.
  2. ↑ "ME Association: contributions towards mitochondrial muscle research". The ME Association. May 17, 2016.
  3. ↑ "ME Association to fund fourth study into the role of the mitochondria in ME/CFS | 10 March 2016". Retrieved August 16, 2019.
  4. ↑ Myhill, Sarah; Booth, Norman E.; McLaren-Howard, John. "Chronic fatigue syndrome and mitochondrial dysfunction". International Journal of Clinical and Experimental Medicine. 2 (1): 1–16. ISSN 1940-5901. PMC 2680051. PMID 19436827.
  5. ↑ MEA Xmas Appeal Announcment November 2016
  6. ↑ Make ME Better! | Why our Christmas Appeal has got personal for Jamie | 23 November 2016
  7. ↑ Metabolic features of chronic fatigue syndrome: R Naviaux et al
  8. ↑ 8.0 8.1 Morten, Karl J.; Newton, Julia L.; Joanna L. Elson; Potter, Michelle; Lodge, Tiffany A.; Tomas, Cara (August 7, 2019). "Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test". Scientific Reports. 9 (1): 1–9. doi:10.1038/s41598-019-47966-z. ISSN 2045-2322.
  9. ↑ Myhill, Sarah (August 2019). "Response to the paper 'Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test' by Cara Tomas et al". drmyhill.co.uk. Retrieved August 16, 2019.
  10. ↑ Xu, Jiabao; Potter, Michelle; Tomas, Cara; Elson, Jo; Morten, Karl; Poulton, Joanna; Wang, Ning; Jin, Hanqing; Hou, Zhaoxu (2018). "A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy". The Analyst. doi:10.1039/C8AN01437J. ISSN 0003-2654.
  11. ↑ Morten, Karl J.; Staines-Urias, Eleonora; Kenyon, Julian (December 2018). "Potential clinical usefulness of gut microbiome testing in a variety of clinical conditions". Human Microbiome Journal. 10: 6–10. doi:10.1016/j.humic.2018.08.003. ISSN 2452-2317.
  12. ↑ Kujawski, Sławomir; Cossington, Jo; Słomko, Joanna; Zawadka-Kunikowska, Monika; Tafil-Klawe, Małgorzata; Klawe, Jacek; Buszko, Katarzyna; Jakovljevic, Djordje; Kozakiewicz, Mariusz; Morten, Karl J.; Dawes, Helen; Strong, James W.L.; Murovska, Modra; Van Oosterwijck, Jessica; Estevez-Lopez, Fernando; Newton, Julia L.; Hodges, Lynette; Zalewski, Paweł; European Network on ME/CFS, (EUROMENE) (April 6, 2021). "Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients". Journal of Clinical Medicine. 10 (7): 1542. doi:10.3390/jcm10071542. ISSN 2077-0383.

Oxford University a prestigious university located in Oxford, England renowned for its teaching and research in health and medicine

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

Canadian Consensus Criteria (CCC) - A set of diagnostic criteria used to diagnose ME/CFS, developed by a group of practicing ME/CFS clinicians in 2003. The CCC is often considered to be the most complex criteria, but possibly the most accurate, with the lowest number of patients meeting the criteria. Led to the development of the International Consensus Criteria (ICC) in 2011.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

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