Indoleamine-2,3-dioxygenase: Difference between revisions

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'''Indoleamine-2,3-dioxygenase''' or '''IDO''' is an [[enzyme]] involved in the human body's metabolism of the essential [[amino acid]] [[tryptophan]].{{citation needed}}
'''Indoleamine-2,3-dioxygenase''' or '''indolamine-2,3-dioxygenase''' or '''IDO''' is an [[enzyme]] involved in the human body's metabolism of the essential [[amino acid]] [[tryptophan]].<ref name="Bilir2017">{{Cite journal | last = Bilir | first = Cemil | authorlink = | last2 = Sarisozen | first2 = Can | authorlink2 = | date = 2017-07-01 | title = Indoleamine 2,3-dioxygenase (IDO): Only an enzyme or a checkpoint controller? | url = http://www.sciencedirect.com/science/article/pii/S2452336417300201|journal=Journal of Oncological Sciences|language=en|volume=3|issue=2 | pages = 52–56|doi=10.1016/j.jons.2017.04.001|issn=2452-3364|pmc=|pmid=|access-date=|quote=|via=}}</ref><ref name="Phair2019" />


The IDO enzyme degrades (converts) [[tryptophan]] into [[kynurenine]], and this process is strongly linked to the [[Indoleamine-2,3-dioxygenase 1|IDO1]] and [[Indoleamine-2,3-dioxygenase 2|IDO2]] genes.<ref name="Bilir2017" /><ref>{{Cite web | url = https://www.ncbi.nlm.nih.gov/gene/3620 | title = IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)] - Gene - NCBI | last = National Center for Biotechnology Information | first = | authorlink = | date = Mar 22, 2020 | website = ncbi.nlm.nih.gov|archive-url=|archive-date=|url-status=|access-date=2020-05-01}}</ref>
== Notable studies and publications ==
* 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS<ref name="Phair2019">{{Cite journal | last = Phair | first = RobertD. | authorlink = Robert Phair | last2 = Davis | first2 = Ronald W. | authorlink2 = Ron Davis | last3 = Kashi | first3 = Alex A. | authorlink3 = Alex Kashi | authorlink4 = | authorlink5 = | authorlink6 = | date = 2019 | title=The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS | url = https://www.mdpi.com/2075-4418/9/3/82|journal=Diagnostics|language=en|volume=9|issue=3 | pages = 82|doi=10.3390/diagnostics9030082|quote=|via=}}</ref> [https://www.mdpi.com/2075-4418/9/3/82/htm (Full text)]
==Learn more ==
==Learn more ==
*2020, IDO and Kynurenine Metabolites in Peripheral and CNS Disorders [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066259/ (Full text)]
*2018, Indoleamine 2, 3-dioxygenase regulation of immune response (Review)<ref name="Wu2018">https://doi.org/10.3892/mmr.2018.8537</ref> [https://doi.org/10.3892/mmr.2018.8537 (Full text)]


==See also ==
==See also ==
*[[Indoleamine-2,3-dioxygenase 1]] (IDO1)
*[[Indoleamine-2,3-dioxygenase 2]] (IDO2)
* [[Metabolic trap]] hypothesis
* [[Metabolic trap]] hypothesis
* [[tryptophan]]
* [[Tryptophan]]
* [[kynurenine pathway]]
* [[Kynurenine pathway]]
* [[ME/CFS Severely Ill, Big Data Study]]
* [[Open Medicine Foundation]]


==References ==
==References ==
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[[Category:Enzymes]]
[[Category:Enzymes]]
[[Category:Genes]]
[[Category:Indoles]]

Latest revision as of 10:59, April 2, 2023

Indoleamine-2,3-dioxygenase or indolamine-2,3-dioxygenase or IDO is an enzyme involved in the human body's metabolism of the essential amino acid tryptophan.[1][2]

The IDO enzyme degrades (converts) tryptophan into kynurenine, and this process is strongly linked to the IDO1 and IDO2 genes.[1][3]

Notable studies and publications[edit | edit source]

  • 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS[2] (Full text)

Learn more[edit | edit source]

  • 2020, IDO and Kynurenine Metabolites in Peripheral and CNS Disorders (Full text)
  • 2018, Indoleamine 2, 3-dioxygenase regulation of immune response (Review)[4] (Full text)

See also[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 Bilir, Cemil; Sarisozen, Can (July 1, 2017). "Indoleamine 2,3-dioxygenase (IDO): Only an enzyme or a checkpoint controller?". Journal of Oncological Sciences. 3 (2): 52–56. doi:10.1016/j.jons.2017.04.001. ISSN 2452-3364.
  2. ↑ 2.0 2.1 Phair, RobertD.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.
  3. ↑ National Center for Biotechnology Information (March 22, 2020). "IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)] - Gene - NCBI". ncbi.nlm.nih.gov. Retrieved May 1, 2020.
  4. ↑ https://doi.org/10.3892/mmr.2018.8537

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indole (IDO) - a signalling molecule produced by bacteria as a result of metabolising tryptophan, found in the intestines

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

metabolic trap hypothesis An hypothesis which proposes that the normal metabolic functioning of the cell has become "trapped" in an abnormal state, which may lead to body-wide symptoms.

etiology The cause of origin, especially of a disease.

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

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