Valine
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Valine or L-valine is one of the nine essential amino acids for humans,[1] and is also available in branched chain amino acid (BCAA) supplements.[2]
Purpose[edit | edit source]
Sources[edit | edit source]
Evidence[edit | edit source]
ME/CFS[edit | edit source]
The genes TRPV1 and VARS2 and their associated proteins influence the effects of valine in the body, and have been implicated in pathophysiology of ME/CFS. The pilot study from the ongoing ME/CFS Gene Study found that VARS2 was one of the ten relatively common genes or gene variants that were significantly more common in people with ME/CFS.[3] Iacob et al. (2016) found differences in gene expression for TRPV1 after moderate exercise in ME/CFS and fibromyalgia patients, transient vanilloid receptor (TRPV1) is associated with pain, fatigue and inflammation, including both increased fatigue and pain during post-exertional malaise in ME/CFS.[4]
Costs and availability[edit | edit source]
Available over the counter, but more often sold as a BCAA supplement.
Branched Chain Amino Acids[edit | edit source]
Valine, along with leucine and isoleucine is branched chain amino acid (BCAA).[2]
AXA1125[edit | edit source]
Valine is one of a number of amino acids in AXA1125, which is undergoing clinical trials for a number of uses.[citation needed]
Risks and safety[edit | edit source]
Notable studies[edit | edit source]
- 2019, Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study[3] (Full text)
- 2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample[4] - (Full text)
See also[edit | edit source]
Learn more[edit | edit source]
- Valine - PubChem
References[edit | edit source]
- ↑ National Center for Biotechnology Information. "PubChem Compound Summary for CID 6287, Valine". Retrieved May 24, 2022.
- ↑ 2.0 2.1 van der Poll, MCG; Luiking, YC; Dejong, CHC; Soeters, PB (September 2, 2009). "Amino Acids". In Caballero, Benjamin (ed.). Guide to Nutritional Supplements. Oxford, UK: Academic Press. pp. 7–8. ISBN 978-0-12-375661-9.
- ↑ 3.0 3.1 Nathanson, Lubov; Craddock, Travis J.A.; Klimas, Nancy G.; Gemayel, Kristina; Del Alamo, Ana; Hilton, Kelly; Jaundoo, Rajeev; Perez, Melanie (2019). "Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00206. ISSN 2296-2360.
- ↑ 4.0 4.1 Iacob, Eli; Light, Alan R.; Donaldson, Gary W.; Okifuji, Akiko; Hughen, Ronald W.; White, Andrea T.; Light, Kathleen C. (January 2016). "Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample". Arthritis care & research. 68 (1): 132–140. doi:10.1002/acr.22639. ISSN 2151-464X. PMC 4684820. PMID 26097208.
