Valine

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Valine or L-valine is one of the nine essential amino acids for humans,[1] and is also available in branched chain amino acid (BCAA) supplements.[2]

Purpose[edit | edit source]

Sources[edit | edit source]

Evidence[edit | edit source]

ME/CFS[edit | edit source]

The genes TRPV1 and VARS2 and their associated proteins influence the effects of valine in the body, and have been implicated in pathophysiology of ME/CFS. The pilot study from the ongoing ME/CFS Gene Study found that VARS2 was one of the ten relatively common genes or gene variants that were significantly more common in people with ME/CFS.[3] Iacob et al. (2016) found differences in gene expression for TRPV1 after moderate exercise in ME/CFS and fibromyalgia patients, transient vanilloid receptor (TRPV1) is associated with pain, fatigue and inflammation, including both increased fatigue and pain during post-exertional malaise in ME/CFS.[4]

Costs and availability[edit | edit source]

Available over the counter, but more often sold as a BCAA supplement.

Branched Chain Amino Acids[edit | edit source]

Valine, along with leucine and isoleucine is branched chain amino acid (BCAA).[2]

AXA1125[edit | edit source]

Valine is one of a number of amino acids in AXA1125, which is undergoing clinical trials for a number of uses.[citation needed]

Risks and safety[edit | edit source]

Notable studies[edit | edit source]

  • 2019, Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study[3](Full text)
  • 2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample[4] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. National Center for Biotechnology Information. "PubChem Compound Summary for CID 6287, Valine". Retrieved May 24, 2022.
  2. 2.02.1 van der Poll, MCG; Luiking, YC; Dejong, CHC; Soeters, PB (September 2, 2009). "Amino Acids". In Caballero, Benjamin (ed.). Guide to Nutritional Supplements. Oxford, UK: Academic Press. pp. 7–8. ISBN 978-0-12-375661-9.
  3. 3.03.1 Nathanson, Lubov; Craddock, Travis J. A.; Klimas, Nancy G.; Gemayel, Kristina; Del Alamo, Ana; Hilton, Kelly; Jaundoo, Rajeev; Perez, Melanie (2019). "Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00206. ISSN 2296-2360.
  4. 4.04.1 Iacob, Eli; Light, Alan R.; Donaldson, Gary W.; Okifuji, Akiko; Hughen, Ronald W.; White, Andrea T.; Light, Kathleen C. (January 2016). "Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample". Arthritis care & research. 68 (1): 132–140. doi:10.1002/acr.22639. ISSN 2151-464X. PMC 4684820. PMID 26097208.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.