Stephen Holgate

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Professor Stephen Holgate was the Chair of the UK CFS/ME Research Collaborative 2013-2020 and chair of the MRC-led ME expert group 2008-2011[1]. He is Medical Research Council Clinical Professor of Immunopharmacology and Honorary Consultant Physician within Medicine at the University of Southampton, Southampton, England.[2]

He was knighted for services to medical research in the 2020 Queen's Birthday Honours List.[3]

Bio in Nature Reviews: "He received his medical degree from the University of London, UK, M.D. by thesis and D.Sc. from the University of Southampton. From 1978 to 1980 he spent a postdoctoral fellowship at Harvard Medical School, Cambridge, Massachusetts, US, researching inflammatory mechanisms. His current research is directed towards the pathophysiology of asthma and allied disorders, with a special interest in understanding how environmental exposures such as allergens, virus infections and air pollutants interact with the airways in the induction and exacerbation of asthma."[4]

Having chaired the UK CFS/ME Research Collaborative since its inception in 2013, he has stated that he wants to develop a "dream team" of the best researchers working on the UK CFS/ME Research Collaborative. One the projects launched by the Collaborative was the Grand Challenge, called such because its goal was to study ten thousand patients.[5]

He believes that ME/CFS could have twelve to fifteen different ‘causal pathways’ and that may be the reason it has been so hard to decipher.[6]

Articles[edit | edit source]

Notable studies[edit | edit source]

Talks and interviews[edit | edit source]

Controversy[edit | edit source]

Stephen Holgate supported and endorsed the controversial online CBT therapy for children research, the FITNET trial, led by Esther Crawley in 2016 which got a lot of media promotion. Dr Esther Crawley claimed that many children could be cured by this & professor Holgate called it the type of high quality research we needed more of [11]

Professor Holgate was a cosignatory of the infamous 2012 letter in the Independent[12] in support of Simon Wessely’s CFS work & his receipt of the Maddox prize for bravery in the “controversial” Chronic Fatigue Syndrome field.

Learn more[edit | edit source]

References[edit | edit source]

  1. "Rising to the challenge of understanding the mechanisms of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/M.E.)" (PDF). The ME association. 2018.
  3. "Professor Stephen Holgate receives Knighthood in the Queen's Birthday Honours List | University of Southampton". Retrieved October 13, 2020.
  5. "Professor Stephen Holgate: UK has "dream team" for Grand Challenge". #MEAction Network. April 28, 2016. Retrieved October 13, 2020.
  6. "A Dozen Different Diseases? Stephen Holgate Calls for Radical Change in ME/CFS Research". Phoenix Rising ME/CFS Forums. Retrieved October 13, 2020.
  7. 7.07.1 Holgate, Stephen T.; Komaroff, Anthony L.; Mangan, Dennis; Wessely, Simon (September 2011). "Chronic fatigue syndrome: understanding a complex illness". Nature Reviews Neuroscience. 12 (9): 539–544. doi:10.1038/nrn3087. ISSN 1471-003X.
  8. "Fighting Over Fatigue: Will This Chronic Syndrome Ever Be Taken Seriously?". The Wire. Retrieved August 17, 2021.
  9. Kaushik, N; Fear, D; Richards, S C M; McDermott, C R; Nuwaysir, E F; Kellam, P; Harrison, T J; Wilkinson, RJ; Tyrrell, D A J; Holgate, S T; Kerr, J R (August 1, 2005). "Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome". Journal of Clinical Pathology. 58 (8): 826–832. doi:10.1136/jcp.2005.025718. ISSN 0021-9746. PMC 1770875. PMID 16049284.
  10. Kerr, Jonathan R; Petty, Robert; Burke, Beverley; Gough, John; Fear, David; Sinclair, Lindsey I; Mattey, Derek L; Richards, Selwyn C; Montgomery, Jane; Baldwin, Don A; Kellam, Paul; Harrison, Tim J; Griffin, George E; Main, Janice; Enlander, Derek; Nutt, David J; Holgate, Stephen T (April 15, 2008), "Gene Expression Subtypes in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis", The Journal of Infectious Diseases, 197 (8): 1171–1184, doi:10.1086/533453
  11. "Landmark chronic fatigue trial could treat two-thirds". BBC News. November 1, 2016. Retrieved August 22, 2021.
  12. "IoS letters, emails & online postings (2 December 2012)". The Independent. December 8, 2012. Retrieved August 24, 2021.

UK CFS/ME Research Collaborative (CMRC) - A UK group of researchers and ME/CFS patient groups led by Professor Stephen Holgate. Its launch in 2013 was covered by the Science Media Centre. Since 2014, the collaborative sponsors the CFS/ME Research Collaborative Conference.

cognitive behavioral therapy (CBT) - A type of psychotherapy geared toward modifying alleged unhealthy thinking, behaviors or illness beliefs. One of the treatment arms used in the controversial PACE trial.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
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