Stephen Holgate

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Professor Stephen Holgate is the Chair of the UK CFS/ME Research Collaborative and Medical Research Council Clinical Professor of Immunopharmacology and Honorary Consultant Physician within Medicine at the University of Southampton, Southampton, England.[1]

Bio in Nature Reviews: "He received his medical degree from the University of London, UK, M.D. by thesis and D.Sc. from the University of Southampton. From 1978 to 1980 he spent a postdoctoral fellowship at Harvard Medical School, Cambridge, Massachusetts, US, researching inflammatory mechanisms. His current research is directed towards the pathophysiology of asthma and allied disorders, with a special interest in understanding how environmental exposures such as allergens, virus infections and air pollutants interact with the airways in the induction and exacerbation of asthma."[2]

Having chaired the UK CFS/ME Research Collaborative since its inception in 2013, he has stated that he wants to develop a "dream team" of the best researchers working on the UK CFS/ME Research Collaborative. One the projects launched by the Collaborative is the Grand Challenge, called such because its goal is to study ten thousand patients.[3]

He believes that ME/CFS could have twelve to fifteen different ‘causal pathways’ and that may be the reason it has been so hard to decipher.[4]

Articles[edit | edit source]

Notable studies[edit | edit source]

Talks and interviews[edit | edit source]

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References[edit | edit source]

  1. http://www.southampton.ac.uk/medicine/about/staff/sth.page
  2. http://www.kcl.ac.uk/innovation/groups/projects/cfs/publications/assets/2011/Holgatecomplexillness.pdf
  3. http://www.meaction.net/2016/04/28/professor-stephen-holgate-uk-has-dream-team-for-grand-challenge/
  4. http://phoenixrising.me/archives/18222
  5. Holgate ST, Komaroff AL, Mangan D, Wessely S. (2011) Chronic fatigue syndrome: understanding a complex illness. Nature Reviews: Neuroscience, 12(9):539-44. Retrieved from http://www.kcl.ac.uk/innovation/groups/projects/cfs/publications/assets/2011/Holgatecomplexillness.pdf on 18 Jul 2016
  6. Kaushik, N; Fear, D; Richards, S C M; McDermott, C R; Nuwaysir, E F; Kellam, P; Harrison, T J; Wilkinson, R J; Tyrrell, D A J; Holgate, S T; Kerr, J R (Aug 1, 2005). "Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome". Journal of Clinical Pathology. 58 (8): 826–832. doi:10.1136/jcp.2005.025718. ISSN 0021-9746. PMC 1770875Freely accessible. PMID 16049284. 
  7. Kerr, Jonathan R; Petty, Robert; Burke, Beverley; Gough, John; Fear, David; Sinclair, Lindsey I; Mattey, Derek L; Richards, Selwyn C; Montgomery, Jane; Baldwin, Don A; Kellam, Paul; Harrison, Tim J; Griffin, George E; Main, Janice; Enlander, Derek; Nutt, David J; Holgate, Stephen T (Apr 15, 2008), "Gene Expression Subtypes in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis", The Journal of Infectious Diseases, 197 (8): 1171–1184, doi:10.1086/533453 
  8. Holgate ST, Komaroff AL, Mangan D, Wessely S. (2011) Chronic fatigue syndrome: understanding a complex illness. Nature Reviews: Neuroscience, 12(9):539-44. doi: 10.1038/nrn3087. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21792218 on 18 Jul 2016

UK CFS/ME Research Collaborative (CMRC) - A UK group of researchers and ME/CFS patient groups led by Professor Stephen Holgate. Its launch in 2013 was covered by the Science Media Centre. Since 2014, the collaborative sponsors the CFS/ME Research Collaborative Conference.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
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