Quetiapine

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Quetiapine, also known under the brand name Seroquel, is an atypical antipsychotic drug which is sometimes used off-label at lower doses to treat insomnia.[1][2][3] Quetiapine is also a dopamine serotonin antagonist.[3]:934

Quetiapine may be used for Schizophrenia, Bipolar disorder (manic depression), or, when combined with an antidepressant, to treat depression.[1]

ME/CFS and Fibromyalgia[edit | edit source]

It is a sedating drug sometimes used for off-label for insomnia, including in patients with Fibromyalgia.[2]:80 [3]

Theory[edit | edit source]

Evidence[edit | edit source]

There are no clinical trials for the use of quetiapine in patients with chronic fatigue syndrome or fibromyalgia. There have been several small clinical trials of 25mg of quetiapine in patients with insomnia, with mixed results.[3]

The International Consensus Criteria primer advises against the use of quetiapine in overweight patients with myalgic encephalomyelitis.[4]:13

Risks and safety[edit | edit source]

Costs and availability[edit | edit source]

Notable studies[edit | edit source]

  • 2012, The role of Antipsychotics in the Management of Fibromyalgia[5] - (Abstract)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 "Seroquel: Drug Uses, Dosage & Side Effects". Drugs.com. Retrieved March 9, 2021.
  2. ↑ 2.0 2.1 Ostalecki, Sharon; Tamler, Martin S. (May 5, 2009). 100 Questions & Answers About Fibromyalgia. Jones & Bartlett Publishers. p. 80. ISBN 978-0-7637-8708-0.
  3. ↑ 3.0 3.1 3.2 3.3 Wilson, Sue; Anderson, Kirstie; Baldwin, David; Dijk, Derk-Jan; Espie, Audrey; Espie, Colin; Gringras, Paul; Krystal, Andrew; Nutt, David (July 4, 2019). "British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update". Journal of Psychopharmacology. 33 (8): 923–947. doi:10.1177/0269881119855343. ISSN 0269-8811.
  4. ↑ Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
  5. ↑ Calandre, Elena P.; Rico-Villademoros, Fernando (February 1, 2012). "The Role of Antipsychotics in the Management of Fibromyalgia". CNS Drugs. 26 (2): 135–153. doi:10.2165/11597130-000000000-00000. ISSN 1179-1934.

A chemical that reduces or helps block the activity of another chemical in the body. For example, most antihistamines are H1 antagonists because they block the H1 histamine receptor, which helps relieve allergy symptoms. The opposite of an agonist.[1][2]

antagonist A chemical that reduces or helps block the activity of another chemical in the body. For example, most antihistamines are H1 antagonists because they block the H1 histamine receptor, which helps relieve allergy symptoms. The opposite of an agonist.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

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