From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Quetiapine, also known under the brand name Seroquel, is an atypical antipsychotic drug which is sometimes used off-label at lower doses to treat insomnia.[1][2][3] Quetiapine is also a dopamine serotonin antagonist.[3]:934

Quetiapine may be used for Schizophrenia, Bipolar disorder (manic depression), or, when combined with an antidepressant, to treat depression.[1]

ME/CFS and Fibromyalgia[edit | edit source]

It is a sedating drug sometimes used for off-label for insomnia, including in patients with Fibromyalgia.[2]:80 [3]

Theory[edit | edit source]

Evidence[edit | edit source]

There are no clinical trials for the use of quetiapine in patients with chronic fatigue syndrome or fibromyalgia. There have been several small clinical trials of 25mg of quetiapine in patients with insomnia, with mixed results.[3]

The International Consensus Criteria primer advises against the use of quetiapine in overweight patients with myalgic encephalomyelitis.[4]:13

Risks and safety[edit | edit source]

Costs and availability[edit | edit source]

Notable studies[edit | edit source]

  • 2012, The role of Antipsychotics in the Management of Fibromyalgia[5] - (Abstract)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]