Fibromyalgia drugs

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Fibromyalgia drugs house the information on prescription drugs currently used and are being researched for the Fibromyalgia (FM/FMS) page.

Drugs[edit | edit source]

There are approved and off-label drugs for treating fibromyalgia (FM). Please Note: The information under "Drugs" is not meant to promote any Rx drug for fibromyalgia or its comorbidities but to inform you of these drugs both approved and off-label. Always consult your doctor and pharmacist for guidance on Rx drug use for any illness or disease.

Brands and their generics can have different side effects and interactions. Review EACH brand name and EACH generic name medication's side effects and possible drug interactions with your doctor and pharmacist.

Pregnant women must always consult with their doctor and pharmacist when taking any prescription drug, over-the-counter drug, supplement, or herbal remedy for side effects, drug interactions, and possible miscarriage, injury, birth defect, addiction, or death to the embryo, fetus, or baby. Breastfeeding women should always talk to their doctor and pharmacist for information about breast milk being laced with the drug she has taken causing side effects, injury, addiction, or death, and drug interactions to the baby consuming her breast milk.

Check with your doctor and pharmacist before using any prescription or over-the-counter drug, supplement, or herbal remedy being administered to a child. Check with your doctor and pharmacist for children's side effects or drug interactions that may not be listed.

FDA approved[edit | edit source]

Fibromyalgia Drugs - FDA Approved
Brand Name Drug

Overview

Generic Drug

Overview

Side Effects

and

Interactions

More on Side Effects and Interactions

Not all side effects or possible drug interactions of brand name or generic name drugs are listed or linked in this chart. Brands and their generics can have different side effects and interactions. Review EACH brand name and EACH generic name medication's side effects and possible drug interactions with your doctor and pharmacist.

Cymbalta[1] Duloxetine[2][3] Cymbalta[4][5]

Duloxetine[6][7]

  • Cymbalta is facing lawsuits due to severe withdrawal symptoms.[8] There is a Facebook group dedicated to questions about the drug and tapering off of it; Cymbalta Hurts Worse.[9] Eli Lilly has settled hundreds of personal injury lawsuits with patients experiencing severe withdrawal symptoms.[10]
Lyrica Pregabalin (2019)[11] Lyrica[12][13]
  • Severe weight gain
Savella[14] Milnacipran[15] Savella[16][17]

Milnacapiran[18][19]

Off-label[edit | edit source]

Off-label Drugs Used For Fibromyalgia
Brand Name

Drug

Overview

Generic Drug

Overview

Off-label Use Side Effects

and

Interactions

More on Side Effects and Interactions

Not all side effects or possible drug interactions of brand name or generic name drugs are listed or linked in this chart. Brands and their generics can have different side effects and interactions. Review EACH brand name and EACH generic name medication's side effects and possible drug interactions with your doctor and pharmacist.

Florinef[20] Fludrocortisone Orthostatic intolerance and POTS Florinef[21][22]

Fludrocortisone[23][24]

  • Interacts with many other medications
Neurontin Gabapentin Pain, sleep Neurontin[25][26]

Gabapentin[27][28]

  • Weight gain
Remeron[29] Mirtazapine Chronic insomnia Rameron[30][31]

Mirtazapine[32][33]

  • Severe weight gain
  • Intense itching
Revia[34] Low dose naltrexone (LDN) Pain, positive mood, sleep quality, and fatigue[35][36] Revia[37][38]

Low dose

naltrexone[39][40]

  • Must be stepped up slowly
  • Opioids will be rendered ineffective
Seroquel[41] Low dose Quetiapine[42] Low dose Chronic insomnia Seroquel[43][44] Low dose

Quetiapine[45][46] Low dose

  • Severe weight gain
  • Although prescribed for sleep it is not recommended for this off-label use.[48][49]
Ultram[50] Tramadol Pain Ultram[51][52]

Tramadol[53][54]

Zanaflex[57] Tizanadine[58] Chronic insomnia Zanaflex[59][60]

Tizanidine[61][62]

Sleep medications[edit | edit source]

Brands and their generics can have different side effects and interactions. Review EACH brand name and EACH generic name medication's side effects and possible drug interactions with your doctor and pharmacist.

Sleep dysfunction is a prominent symptom in FM. There are four types of sleep medications used for FM; antihistamines, benzodiazepines, nonbenzodiazepines, sedating antidepressants.[63]

Drug trials[edit | edit source]

  • ASP8062
  • IMC-1
Almost three years ago, Dr. Pridgen threatened to turn the world of fibromyalgia treatment on its head. Few had connected fibromyalgia with viruses or even immune problems when Pridgen announced that a) FM is caused herpes simplex virus reactivation and b) that it could be treated with antivirals.[66]
In the successful Phase II trial in fibromyalgia, IMC-1 was studied to confirm the hypothesis that chronic tissue-resident herpes simplex virus type 1 (HSV-1) may be one of the underlying causes of fibromyalgia and causally related to fibromyalgia symptoms or recurrence. IMC-1 is a novel fixed-dose oral combination antiviral medication designed to suppress this suspected virus and thus alleviate fibromyalgia symptoms.[67]
First there were the anecdotal reports – FM patients were not just getting better but some, and not just a few, were getting well using something entirely new – an antiviral protocol, of all things, created not by a pain specialist or rheumatologist but by a surgeon.[68]
IMC-1 was efficacious and safe in treating symptoms of fibromyalgia, supporting the hypothesis that herpes virus infections may contribute to this syndrome. Improved retention rates, decreased adverse event rates, and evidence of efficacy on a broad spectrum of outcome measures are suggestive that IMC-1 may represent an effective, novel treatment for fibromyalgia.[69]
  • Bacille Calmette-Guerin (BCG) vaccine

Drug trials failed[edit | edit source]

  • TNX-102
  • 2016, The drug failed in its primary goal in providing pain relief and Tonix Pharmaceuticals will not be moving forward in developing a Ffbromyalgia drug.[72]
  • Phase III clinical trial of DS-5565 found ineffective
In the three 13-week, double-blind, global, phase 3 ALDAY clinical trials evaluating Mirogabalin for the treatment of pain associated with fibromyalgia, Mirogabalin did not meet the primary efficacy endpoint to demonstrate a statistically significant reduction in the weekly average of worst daily pain score from baseline to Week 13.[73]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Cymbalta Uses, Dosage, Side Effects & Warnings - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  2. "Duloxetine: Uses, Side Effects, Dosage, Warnings - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  3. "Duloxetine". Wikipedia. Aug 5, 2018. 
  4. "Cymbalta Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  5. "Cymbalta Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  6. "Duloxetine Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  7. "Duloxetine Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  8. Miller, Emily. "Cymbalta Lawsuit - Settlements, Withdrawal & Suicide Claims". Drugwatch.com. Retrieved Aug 21, 2018. 
  9. "Cymbalta Hurts Worse". www.facebook.com. Retrieved Aug 23, 2018. 
  10. "Eli Lilly Settles Cymbalta Withdrawal Lawsuits". National Pain Report. Oct 6, 2016. Retrieved Aug 21, 2018. 
  11. "Court Blocks Sale of Generic Lyrica, Upholds Pfizer Patents - Non-opioid Pain Medication - Chronic Pain | HealthCentral". www.healthcentral.com. Retrieved Aug 21, 2018. 
  12. "Lyrica Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  13. "Lyrica Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  14. "Savella (milnacipran) Uses, Dosage, Side Effects - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  15. "Milnacipran Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  16. "Savella Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  17. "Savella Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  18. "Milnacipran Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  19. "Milnacipran Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  20. "Florinef Dosage Guide - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  21. "Florinef Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  22. "Florinef Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  23. "Fludrocortisone Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  24. "Fludrocortisone Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  25. "Neurontin Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  26. "Neurontin Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  27. "Gabapentin Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  28. "Gabapentin Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  29. "Remeron: Side Effects, Dosage & Uses - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  30. "Remeron Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  31. "Remeron Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  32. "Mirtazapine Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  33. "Mirtazapine Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  34. "ReVia Uses, Side Effects & Warnings - Drugs.com". Drugs.com. Retrieved Sep 4, 2018. 
  35. Younger, Jarred; Noor, Noorulain; McCue, Rebecca; Mackey, Sean (Jan 28, 2013). "Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels". Arthritis & Rheumatism. 65 (2): 529–538. doi:10.1002/art.37734. ISSN 0004-3591. 
  36. "Low Dose Naltrexone for Fibromyalgia". Systems Neuroscience and Pain Lab. Retrieved Oct 4, 2018. 
  37. "Revia Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  38. "Revia Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  39. "Naltrexone Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  40. "Naltrexone Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  41. "Seroquel: Drug Uses, Dosage & Side Effects - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  42. "Quetiapine Uses, Side Effects & Warnings - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  43. "Seroquel Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  44. "Seroquel Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  45. "Quetiapine Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  46. "Quetiapine Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  47. "Suicidal ideation". Wikipedia. Aug 31, 2018. 
  48. Coe, Holly V; Hong, Irene S (Apr 17, 2012). "Safety of Low Doses of Quetiapine When Used for Insomnia". Annals of Pharmacotherapy. 46 (5): 718–722. doi:10.1345/aph.1q697. ISSN 1060-0280. 
  49. Maglione, Margaret; Maher, Alicia Ruelaz; Hu, Jianhui; Wang, Zhen; Shanman, Roberta; Shekelle, Paul G.; Roth, Beth; Hilton, Lara; Suttorp, Marika J. (2011). Off-Label Use of Atypical Antipsychotics: An Update. AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID 22132426. 
  50. "Ultram Uses, Dosage & Side Effects - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  51. "Ultram Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  52. "Ultram Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  53. "Tramadol Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  54. "Tramadol Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
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  56. Eustice, Carol (Dec 19, 2018). "Tramadol Can Be Dangerous if Not Used as Directed by Your Doctor". Verywell Health. Serious side effects include:. Retrieved Feb 20, 2019. 
  57. "Zanaflex: Uses, Dosage & Side Effects - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  58. "Tizanidine Uses, Dosage, Side Effects - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  59. "Zanaflex Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  60. "Zanaflex Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  61. "Tizanidine Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  62. "Tizanidine Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 21, 2018. 
  63. Sue (Dec 17, 2014). "Sleep Medications For Fibromyalgia •". Fibrodaze (Blog). Retrieved Aug 9, 2018. 
  64. "A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia - Full Text View - ClinicalTrials.gov". Retrieved Aug 9, 2018. 
  65. Henriques, Carolina (Mar 27, 2017). "Intec Pharma Launches Phase 1 Trial of Cannabinoid-based Therapy for Fibromyalgia, Lower Back Pain". Fibromyalgia News Today. Retrieved Aug 9, 2017. 
  66. 66.066.1 Johnson, Cort (Oct 17, 2016). "The Pridgen Revolution? Dr. Pridgen on Bringing His Antiviral Approach to Fibromyalgia To Market - Simmaron Research". Simmaron Research. Retrieved Aug 9, 2018. 
  67. 67.067.1 Moore, Charles (Feb 2, 2016). "Novel Fibromyalgia Treatment Granted FDA Fast Track Designation - Fibromyalgia News Today". Fibromyalgia News Today. Retrieved Aug 9, 2018. 
  68. 68.068.1 Johnson, Cort (Mar 26, 2017). "Through the "Valley of Death": Dr. Pridgen, Fibromyalgia and the Looming Trials - Simmaron Research". Simmaron Research. Retrieved Aug 9, 2018. 
  69. 69.069.1 Pridgen, William L; Duffy, Carol; Gendreau, Judy F; Gendreau, R Michael (Feb 22, 2017). "A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia". Journal of Pain Research. 10: 451–460. doi:10.2147/JPR.S127288. ISSN 1178-7090. PMID 28260944. 
  70. Gregory Burch, Donna (Aug 14, 2017). "Century-old Vaccine Gives New Hope to Fibromyalgia Community - Prohealth". Prohealth. Retrieved Aug 9, 2018. 
  71. Coghlan, Ed (Sep 5, 2018). "Can an Existing Vaccine Help Treat Fibromyalgia?". National Pain Report. Retrieved Sep 10, 2018. 
  72. Gregory Burch, Donna (Sep 10, 2016). "Potential Fibromyalgia Treatment is Put on Hold". National Pain Report. Retrieved Aug 9, 2018. 
  73. 73.073.1 Johnson, Cort (Jul 8, 2017). "The Big Hurt: Second Major Fibromyalgia Drug in a Year Fails - Health Rising". Health Rising. Retrieved Aug 9, 2018. 
  74. Reid, Alyssa (May 23, 2016). "Tramadol: The Seizure and Blackout Connection". FibroMapp Pain Manager+. Retrieved Aug 21, 2018. 
  75. Dellwo, Adrienne (Apr 30, 2016). "How Lyrica Changes the Fibromyalgia Brain". Verywell Health. Retrieved Sep 19, 2018. 
  76. Gregory, Donna (May 28, 2015). "Why your fibro meds aren't working | Fed Up with Fatigue". Fed Up with Fatigue. Retrieved Aug 9, 2018. 

Last phase of clinical trials before a drug can be approved for public use.[1]

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.